HK1003891A1 - Tricyclic vasopressin antagonists - Google Patents

Tricyclic vasopressin antagonists

Info

Publication number
HK1003891A1
HK1003891A1 HK98103196A HK98103196A HK1003891A1 HK 1003891 A1 HK1003891 A1 HK 1003891A1 HK 98103196 A HK98103196 A HK 98103196A HK 98103196 A HK98103196 A HK 98103196A HK 1003891 A1 HK1003891 A1 HK 1003891A1
Authority
HK
Hong Kong
Prior art keywords
vasopressin antagonists
tricyclic
tricyclic vasopressin
antagonists
vasopressin
Prior art date
Application number
HK98103196A
Other languages
English (en)
Inventor
Aranapakam Mudumbai Venkatesan
Jay Donald Albright
George Theodore Grosu
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of HK1003891A1 publication Critical patent/HK1003891A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/06—Antiabortive agents; Labour repressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Reproductive Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Emergency Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Obesity (AREA)
  • Pulmonology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
HK98103196A 1995-01-17 1998-04-16 Tricyclic vasopressin antagonists HK1003891A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/373,125 US5521173A (en) 1995-01-17 1995-01-17 Tricyclic benzazepine vasopressin antagonists
PCT/US1996/000515 WO1996022292A1 (en) 1995-01-17 1996-01-16 Tricyclic vasopressin antagonists

Publications (1)

Publication Number Publication Date
HK1003891A1 true HK1003891A1 (en) 1998-11-13

Family

ID=23471074

Family Applications (1)

Application Number Title Priority Date Filing Date
HK98103196A HK1003891A1 (en) 1995-01-17 1998-04-16 Tricyclic vasopressin antagonists

Country Status (24)

Country Link
US (2) US5521173A (de)
EP (1) EP0805813B1 (de)
JP (2) JP4156664B2 (de)
CN (1) CN1052725C (de)
AR (1) AR002021A1 (de)
AT (1) ATE217625T1 (de)
AU (1) AU707881B2 (de)
BR (1) BR9607177A (de)
CA (1) CA2210708C (de)
CZ (1) CZ224797A3 (de)
DE (1) DE69621225T2 (de)
DK (1) DK0805813T3 (de)
EA (1) EA000056B1 (de)
ES (1) ES2175066T3 (de)
HK (1) HK1003891A1 (de)
HU (1) HUP9702459A3 (de)
IL (1) IL116774A (de)
MX (1) MX9705414A (de)
NZ (1) NZ301198A (de)
PT (1) PT805813E (de)
TW (1) TW472056B (de)
UA (1) UA48960C2 (de)
WO (1) WO1996022292A1 (de)
ZA (1) ZA96303B (de)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5736540A (en) * 1993-07-29 1998-04-07 American Cyanamid Company Tricyclic diazepine vasopressin antagonists and oxytocin antagonists
US5700796A (en) * 1995-01-17 1997-12-23 American Cyanamid Company Tricyclic benzazepine vasopressin antagonists
US5753648A (en) * 1995-01-17 1998-05-19 American Cyanamid Company Tricyclic benzazepine vasopressin antagonists
US5880122A (en) * 1996-11-01 1999-03-09 American Home Products Corporation 3-Carboxamide derivatives of 5H-pyrrolo 2,1-c! 1,4!-benzodiazepines
AU732214C (en) * 1997-03-31 2001-10-25 Wakamoto Pharmaceutical Co., Ltd. Biphenyl derivatives and drug composition
US6511974B1 (en) 1997-07-30 2003-01-28 Wyeth Tricyclic vasopressin agonists
PT1000062E (pt) * 1997-07-30 2004-12-31 Wyeth Corp Agonistas triciclicos de vasopressina
US6194407B1 (en) 1997-07-30 2001-02-27 American Home Products Corporation Tricyclic pyrido vasopressin agonists
US6090803A (en) * 1998-07-24 2000-07-18 American Home Products Corporation Tricyclic vasopressin agonists
US7138393B2 (en) * 1998-07-24 2006-11-21 Wyeth Biologically active vasopressin agonist metabolites
IL144270A0 (en) * 1999-01-19 2002-05-23 Ortho Mcneil Pharm Inc Tricyclic benzodiazepines as vasopressin receptor antagonists
CA2358891A1 (en) * 1999-02-04 2000-08-10 Amedeo Arturo Failli Thienylbenzoylbenzazepines as vasopressin agonists
US6235900B1 (en) 1999-02-04 2001-05-22 American Home Products Corporation Tricyclic pyridine N-oxides vasopressin agonists
US6297234B1 (en) 1999-02-04 2001-10-02 American Home Products Corporation Arylthiophene vasopressin agonists
US6344451B1 (en) 1999-02-04 2002-02-05 American Home Products Pyrrolobenzodiazepine carboxyamide vasopressin agonists
US6620807B1 (en) 1999-02-04 2003-09-16 Wyeth Pyridobenzodiazepine and pyridobenzoxazepine carboxyamide vasopressin agonists
WO2001022969A2 (en) * 1999-09-27 2001-04-05 American Cynamid Company Vasopressin agonist formulation and process
EP1390347B1 (de) * 2001-03-20 2008-05-07 Laboratoires Serono SA Pyrrolidinesterderivate mit oxytocinmodulierender wirkung
US6977254B2 (en) * 2001-04-12 2005-12-20 Wyeth Hydroxy cyclohexenyl phenyl carboxamides tocolytic oxytocin receptor antagonists
US7022699B2 (en) 2001-04-12 2006-04-04 Wyeth Cyclohexenyl phenyl diazepines vasopressin and oxytocin receptor modulators
US7202239B2 (en) * 2001-04-12 2007-04-10 Wyeth Cyclohexylphenyl carboxamides tocolytic oxytocin receptor antagonists
US6903087B2 (en) * 2001-04-12 2005-06-07 Wyeth Pyrido cyclohexenyl phenyl carboxamides tocolytic oxytocin receptor antagonists
DE60218646T2 (de) * 2001-04-12 2007-11-22 Wyeth N-biphenylcarbonyl- und n-phenylpyridylcarbonyl substituierte bi- und tricyclische azepine und diazepine als vasopressin-agonisten
US7326700B2 (en) * 2001-04-12 2008-02-05 Wyeth Cyclohexenyl phenyl carboxamides tocolytic oxytocin receptor antagonists
US7053083B2 (en) * 2001-04-12 2006-05-30 Wyeth Cyclohexylphenyl vasopressin agonists
US6900200B2 (en) * 2001-04-12 2005-05-31 Wyeth Tricyclic hydroxy carboxamides and derivatives thereof tocolytic oxytocin receptor antagonists
US7109193B2 (en) * 2001-04-12 2006-09-19 Wyeth Tricyclic diazepines tocolytic oxytocin receptor antagonists
US7064120B2 (en) * 2001-04-12 2006-06-20 Wyeth Tricyclic pyridyl carboxamides and derivatives thereof tocolytic oxytocin receptor antagonists
WO2003037901A1 (en) * 2001-10-29 2003-05-08 Ortho-Mcneil Pharmaceutical, Inc. Bridged bicycle (1,4) benzodiazepine vasopressin receptor antagonists
US7119088B2 (en) * 2003-02-19 2006-10-10 Pfizer Inc. Triazole compounds useful in therapy
CA2660799C (en) * 2006-08-14 2013-03-19 Council Of Scientific & Industrial Research Pyrrolo[2,1-c][1,4]benzodiazepine hybrids and a process for the preparation thereof
MY161369A (en) 2008-06-10 2017-04-14 Abbvie Inc Novel tricyclic compounds
DK2356123T3 (da) 2008-11-13 2012-10-15 Hoffmann La Roche Spiro-5,6-dihydro-4h-2,3,5,10b-tetraaza-benzo[e]azulener
CN102216304B (zh) 2008-11-18 2014-07-09 弗·哈夫曼-拉罗切有限公司 二氢四氮杂苯并薁的烷基环己基醚
RU2507205C2 (ru) 2008-11-28 2014-02-20 Ф. Хоффманн-Ля Рош Аг Арилциклогексилэфиры дигидротетраазабензоазуленов для применения в качестве антагонистов рецептора вазопрессина v1a
PE20130005A1 (es) 2009-12-01 2013-02-16 Abbvie Inc Compuestos triciclicos novedosos
TWI500620B (zh) 2009-12-01 2015-09-21 Abbvie Inc 新穎三環化合物
US8420633B2 (en) 2010-03-31 2013-04-16 Hoffmann-La Roche Inc. Aryl-cyclohexyl-tetraazabenzo[e]azulenes
US8461151B2 (en) 2010-04-13 2013-06-11 Hoffmann-La Roche Inc. Aryl-/heteroaryl-cyclohexenyl-tetraazabenzo[e]azulenes
US8492376B2 (en) 2010-04-21 2013-07-23 Hoffmann-La Roche Inc. Heteroaryl-cyclohexyl-tetraazabenzo[e]azulenes
US8481528B2 (en) 2010-04-26 2013-07-09 Hoffmann-La Roche Inc. Heterobiaryl-cyclohexyl-tetraazabenzo[e]azulenes
WO2011150457A2 (en) 2010-06-01 2011-12-08 The University Of Queensland Haematopoietic-prostaglandin d2 synthase inhibitors
CN103288829A (zh) * 2012-02-24 2013-09-11 中国科学院大连化学物理研究所 一种合成手性二氢-5H-吡咯并[2,1-c][1,4]-苯并二氮杂卓-5-酮的方法
WO2014060381A1 (de) 2012-10-18 2014-04-24 Bayer Cropscience Ag Heterocyclische verbindungen als schädlingsbekämpfungsmittel
JP2016503395A (ja) 2012-10-31 2016-02-04 バイエル・クロップサイエンス・アクチェンゲゼルシャフト 病害生物防除剤としての複素環化合物
EP2970205B1 (de) 2013-03-14 2019-05-08 Tolero Pharmaceuticals, Inc. Jak2- und alk2-inhibitoren und verfahren zu deren verwendung
US11512092B2 (en) 2015-10-16 2022-11-29 Abbvie Inc. Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-n-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof
US11365198B2 (en) 2015-10-16 2022-06-21 Abbvie Inc. Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof
US11524964B2 (en) 2015-10-16 2022-12-13 Abbvie Inc. Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-n-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof
US11773106B2 (en) 2015-10-16 2023-10-03 Abbvie Inc. Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof
WO2017066775A1 (en) 2015-10-16 2017-04-20 Abbvie Inc. PROCESSES FOR THE PREPARATION OF (3S,4R)-3-ETHYL-4-(3H-IMIDAZO[1,2-a]PYRROLO[2,3-e]-PYRAZIN-8-YL)-N-(2,2,2-TRIFLUOROETHYL)PYRROLIDINE-1-CARBOXAMIDE AND SOLID STATE FORMS THEREOF
US10550126B2 (en) 2015-10-16 2020-02-04 Abbvie Inc. Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-A]pyrrolo[2,3-e]-pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof
JP2021530554A (ja) 2018-07-26 2021-11-11 スミトモ ダイニッポン ファーマ オンコロジー， インコーポレイテッド 異常なａｃｖｒ１発現を伴う疾患を処置するための方法およびそこで使用するためのａｃｖｒ１阻害剤

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3763183A (en) * 1972-07-10 1973-10-02 Sterling Drug Inc 1,2,3,10,11,11a-hexahydro-5h-pyrrolo (2,1-c)(1,4)benzodiazepines
US4766108A (en) * 1986-12-04 1988-08-23 Smith Kline Beckman Corporation Tyr-Arg-vasopressin antagonists
US5055448A (en) * 1987-06-25 1991-10-08 Medical College Of Ohio Linear derivatives of arginine vasopressin antagonists
DK0382185T3 (da) * 1989-02-10 1994-07-04 Otsuka Pharma Co Ltd Carbostyrilderivater
EP0450097B1 (de) * 1989-10-20 1996-04-24 Otsuka Pharmaceutical Co., Ltd. Benzoheterozyklische verbindungen
US5258510A (en) * 1989-10-20 1993-11-02 Otsuka Pharma Co Ltd Benzoheterocyclic compounds
US5070187A (en) * 1989-11-03 1991-12-03 Trustees Of Boston University Pharmacologically effective antagonists of arginine-vasopressin
TW199153B (de) * 1990-08-07 1993-02-01 Dtsuka Seiyaku Kk
CA2066104C (en) * 1991-04-19 2003-05-27 Hidenori Ogawa Benzazepine derivatives as vasopressin antagonists
EP0533242A3 (en) * 1991-09-16 1993-09-15 Merck & Co. Inc. Substituted derivatives of piperazinylcamphorsulfonyl oxytocin antagonists
DE69223573D1 (de) * 1991-09-16 1998-01-29 Merck & Co Inc Hydantoin und Succinimid-substituierte Spiroindanylcamphorsulfonyl als Oxytocin-Antagonisten
US5204349A (en) * 1991-09-16 1993-04-20 Merck & Co., Inc. Amide-substituted derivatives of spiroindanylcamphorsulfonyl oxytocin antagonists
EP0533240A3 (en) * 1991-09-16 1993-09-29 Merck & Co. Inc. Substituted amine derivatives of piperazinylcamphorsulfonyl oxytocin antagonists
WO1994004525A1 (en) * 1992-08-20 1994-03-03 Otsuka Pharmaceutical Company, Limited Benzoheterocyclic compounds as oxytocin and vasopressin antagonists
WO1994012476A1 (en) * 1992-11-25 1994-06-09 Yamanouchi Pharmaceutical Co., Ltd. Benzanilide derivative
WO1994014796A1 (en) * 1992-12-21 1994-07-07 Yamanouchi Pharmaceutical Co., Ltd. Novel n-(pyridylcarbonyl)benzazepine derivative and intermediate therefor
AU6219994A (en) * 1993-03-11 1994-09-26 Yamanouchi Pharmaceutical Co., Ltd. Compound with vasopressin antagonism
GB9307527D0 (en) * 1993-04-13 1993-06-02 Fujisawa Pharmaceutical Co New venzamide derivatives,processes for the preparation thereof and pharmaceutical composition comprising the same
US5516774A (en) * 1993-07-29 1996-05-14 American Cyanamid Company Tricyclic diazepine vasopressin antagonists and oxytocin antagonists

Also Published As

Publication number Publication date
ES2175066T3 (es) 2002-11-16
IL116774A0 (en) 1996-05-14
CA2210708C (en) 2005-05-24
UA48960C2 (uk) 2002-09-16
ATE217625T1 (de) 2002-06-15
EA199700118A1 (ru) 1997-12-30
JP4156664B2 (ja) 2008-09-24
DK0805813T3 (da) 2002-08-05
EP0805813B1 (de) 2002-05-15
US5780471A (en) 1998-07-14
AU4656696A (en) 1996-08-07
MX9705414A (es) 1997-11-29
CZ224797A3 (cs) 1998-03-18
AR002021A1 (es) 1998-01-07
IL116774A (en) 2000-12-06
JPH11500424A (ja) 1999-01-12
HUP9702459A2 (hu) 1998-05-28
DE69621225T2 (de) 2002-11-14
HUP9702459A3 (en) 2000-08-28
WO1996022292A1 (en) 1996-07-25
EA000056B1 (ru) 1998-04-30
CN1178532A (zh) 1998-04-08
US5521173A (en) 1996-05-28
NZ301198A (en) 1999-08-30
JP2008069176A (ja) 2008-03-27
DE69621225D1 (de) 2002-06-20
PT805813E (pt) 2002-10-31
TW472056B (en) 2002-01-11
AU707881B2 (en) 1999-07-22
EP0805813A1 (de) 1997-11-12
BR9607177A (pt) 1997-11-11
CA2210708A1 (en) 1996-07-25
ZA96303B (en) 1997-07-15
CN1052725C (zh) 2000-05-24

Similar Documents

Publication Publication Date Title
HK1003891A1 (en) Tricyclic vasopressin antagonists
ZA96297B (en) Tricyclic benzazepine vasopressin antagonists
ZA96300B (en) Tricyclic benzazepine vasopressin antagonists
IL127470A0 (en) Tricyclic benzazepine vasopressin antagonists
ZA96299B (en) Tricyclic benzazepine vasopressin antagonists
BR9606977A (pt) Antagonistas de vasopressina de benzazepina triciclica
HUT74808A (en) Gnrh antagonists
IL133788A0 (en) Tricyclic vasopressin agonists
HU9600663D0 (en) Endothelin-receptor antagonists
ZA96298B (en) Tricyclic benzazepine vasopressin antagonists
HU9601176D0 (en) Adhesion-receptor antagonists
PL314120A1 (en) B-adrenergic antagonists
EP0729472A4 (de) Piperidinylkampfersulfonyle als oxytocin-antagonisten
AU3641497A (en) Tricyclic benzazepine vasopressin antagonists
HU9503191D0 (en) Adhesion-receptor antagonists
HK1018057A1 (en) Tricyclic benzazepine compounds
AU3296597A (en) Tricyclic benzazepine vasopressin antagonists
AU3296497A (en) Tricyclic benzazepine vasopressin antagonists
HU9602253D0 (en) Endothelin-receptor antagonists
ZA969987B (en) Lh-rh antagonists
AU6161894A (en) Cholecystokinin antagonists
SI0804438T1 (sl) Triciklicni benzazepinski antagonisti vazopresina
GB9524346D0 (en) Polycyclic compounds
GB9524375D0 (en) Luminescent mixture
ZA961293B (en) Muscarinic antagonists

Legal Events

Date Code Title Description
PF Patent in force
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20060116