HK1002281A1 - Hindered n-oxide esters of rapamycin and their use as medicaments - Google Patents

Hindered n-oxide esters of rapamycin and their use as medicaments

Info

Publication number
HK1002281A1
HK1002281A1 HK98101292A HK98101292A HK1002281A1 HK 1002281 A1 HK1002281 A1 HK 1002281A1 HK 98101292 A HK98101292 A HK 98101292A HK 98101292 A HK98101292 A HK 98101292A HK 1002281 A1 HK1002281 A1 HK 1002281A1
Authority
HK
Hong Kong
Prior art keywords
rapamycin
medicaments
hindered
alkyl
oxide esters
Prior art date
Application number
HK98101292A
Other languages
English (en)
Inventor
Frances Christy Nelson
Guy Alan Schiehser
Original Assignee
American Home Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Prod filed Critical American Home Prod
Publication of HK1002281A1 publication Critical patent/HK1002281A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
HK98101292A 1994-11-28 1998-02-19 Hindered n-oxide esters of rapamycin and their use as medicaments HK1002281A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/345,972 US5491231A (en) 1994-11-28 1994-11-28 Hindered N-oxide esters of rapamycin
PCT/US1995/015318 WO1996016967A1 (en) 1994-11-28 1995-11-22 Hindered n-oxide esters of rapamycin and their use as medicaments

Publications (1)

Publication Number Publication Date
HK1002281A1 true HK1002281A1 (en) 1998-08-14

Family

ID=23357367

Family Applications (1)

Application Number Title Priority Date Filing Date
HK98101292A HK1002281A1 (en) 1994-11-28 1998-02-19 Hindered n-oxide esters of rapamycin and their use as medicaments

Country Status (19)

Country Link
US (5) US5491231A (hu)
EP (1) EP0794955B1 (hu)
JP (1) JPH10509977A (hu)
KR (1) KR100377278B1 (hu)
AT (1) ATE203539T1 (hu)
AU (1) AU712998B2 (hu)
BR (1) BR9509825A (hu)
CA (1) CA2205577A1 (hu)
DE (1) DE69521907T2 (hu)
DK (1) DK0794955T3 (hu)
ES (1) ES2158959T3 (hu)
FI (1) FI972240A (hu)
GR (1) GR3036712T3 (hu)
HK (1) HK1002281A1 (hu)
HU (1) HUT77139A (hu)
MX (1) MX9703893A (hu)
NZ (1) NZ297661A (hu)
PT (1) PT794955E (hu)
WO (1) WO1996016967A1 (hu)

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Also Published As

Publication number Publication date
MX9703893A (es) 1997-08-30
DK0794955T3 (da) 2001-09-24
WO1996016967A1 (en) 1996-06-06
FI972240A0 (fi) 1997-05-27
US5508285A (en) 1996-04-16
US5521194A (en) 1996-05-28
EP0794955A1 (en) 1997-09-17
DE69521907T2 (de) 2001-11-29
NZ297661A (en) 2000-01-28
GR3036712T3 (en) 2001-12-31
EP0794955B1 (en) 2001-07-25
BR9509825A (pt) 1997-09-30
FI972240A (fi) 1997-05-27
KR100377278B1 (ko) 2003-10-04
ATE203539T1 (de) 2001-08-15
US5559122A (en) 1996-09-24
PT794955E (pt) 2001-12-28
DE69521907D1 (de) 2001-08-30
CA2205577A1 (en) 1996-06-06
US5508290A (en) 1996-04-16
AU4287796A (en) 1996-06-19
AU712998B2 (en) 1999-11-18
JPH10509977A (ja) 1998-09-29
ES2158959T3 (es) 2001-09-16
HUT77139A (hu) 1998-03-02
US5491231A (en) 1996-02-13

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