GR890100514A - Processes for the preparation of mitomycin derivatives having reduced bone marrow toxicity - Google Patents
Processes for the preparation of mitomycin derivatives having reduced bone marrow toxicityInfo
- Publication number
- GR890100514A GR890100514A GR89100514A GR890100514A GR890100514A GR 890100514 A GR890100514 A GR 890100514A GR 89100514 A GR89100514 A GR 89100514A GR 890100514 A GR890100514 A GR 890100514A GR 890100514 A GR890100514 A GR 890100514A
- Authority
- GR
- Greece
- Prior art keywords
- processes
- preparation
- bone marrow
- reduced bone
- marrow toxicity
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US23522488A | 1988-08-23 | 1988-08-23 |
Publications (2)
Publication Number | Publication Date |
---|---|
GR890100514A true GR890100514A (en) | 1991-12-30 |
GR1000785B GR1000785B (el) | 1992-12-30 |
Family
ID=22884628
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GR890100514A GR1000785B (el) | 1988-08-23 | 1989-08-18 | Μεθοδοι παρασκευης παραγωγων μιτομυκινης που εχουν μειωμενη τοξικοτητα μυελου των οστων |
Country Status (16)
Country | Link |
---|---|
EP (1) | EP0431008A4 (el) |
JP (1) | JPH04500513A (el) |
KR (1) | KR900701269A (el) |
CN (1) | CN1040593A (el) |
AU (1) | AU628846B2 (el) |
CA (1) | CA1327037C (el) |
DK (1) | DK29691A (el) |
ES (1) | ES2018726A6 (el) |
GR (1) | GR1000785B (el) |
IE (1) | IE63036B1 (el) |
IL (1) | IL91332A0 (el) |
NO (1) | NO177673C (el) |
NZ (1) | NZ230343A (el) |
PT (1) | PT91499B (el) |
WO (1) | WO1990001931A1 (el) |
ZA (1) | ZA896025B (el) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5091523A (en) * | 1990-04-25 | 1992-02-25 | Georgetown University | Mitomycin derivatives having reduced bone marrow toxicity, processes for their preparation, and the uses thereof |
EP0485904B1 (en) * | 1990-11-13 | 1997-08-20 | Kyowa Hakko Kogyo Co., Ltd. | Mitomycin derivatives |
GB2282384B8 (en) * | 1993-08-18 | 1997-09-04 | Europ Economic Community | Drug delivery agents incorporating mitomycin |
CN104231045B (zh) * | 2014-08-22 | 2017-10-31 | 亚飞(上海)生物医药科技有限公司 | 一种靶向激活释放的丝裂霉素衍生物及其用途 |
JP6854759B2 (ja) | 2014-08-22 | 2021-04-07 | ヤフェイ シャンハイ バイオログ メディスン サイエンス アンド テクノロジー カンパニー リミテッド | 腫瘍微環境によって特異的活性化する小分子標的結合体およびその使用 |
US9801909B2 (en) | 2015-04-06 | 2017-10-31 | The Penn State Research Foundation | Compositions and methods for combating bacterial infections by killing persister cells with mitomycin C |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS601197A (ja) * | 1983-06-17 | 1985-01-07 | Kyowa Hakko Kogyo Co Ltd | マイトマイシン誘導体 |
WO1986007260A1 (en) * | 1985-06-06 | 1986-12-18 | Georgetown University | 1a-7-SUBSTITUTED DERIVATIVES OF MITOMYCIN AND USES THEREOF |
JPS63246336A (ja) * | 1986-11-10 | 1988-10-13 | Kyowa Hakko Kogyo Co Ltd | マイトマイシン−抗体複合体含有組成物 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US479130A (en) * | 1892-07-19 | Rudolf allert | ||
US3226393A (en) * | 1962-06-07 | 1965-12-28 | American Cyanamid Co | N-substituted derivatives of mitomycin a and mitomycin c |
DE1570029A1 (de) * | 1964-07-09 | 1970-04-09 | Kyowa Hakko Kogyo Kk | Verfahren zur Herstellung von Mitosanverbindungen |
US3367945A (en) * | 1965-05-18 | 1968-02-06 | Kyowa Hakko Kogyo Kk | Thiourea derivatives of mitomycin |
JPS5240B2 (el) * | 1973-12-17 | 1977-01-05 | ||
JPS5630978A (en) * | 1979-08-24 | 1981-03-28 | Kyowa Hakko Kogyo Co Ltd | Novel mitomycin and its preparation |
US4268676A (en) * | 1979-12-05 | 1981-05-19 | University Patents, Inc. | Mitomycin analogs |
US4746746A (en) * | 1983-02-07 | 1988-05-24 | University Patents, Inc. | Mitomycin analogs |
US4814445A (en) * | 1984-09-04 | 1989-03-21 | Bristol-Myers Company | Process for preparing mitomycin analogs |
DE3674043D1 (de) * | 1985-04-10 | 1990-10-18 | Kyowa Hakko Kogyo Kk | Pharmakologisch aktive mitomycinderivate. |
JPS6354380A (ja) * | 1986-08-26 | 1988-03-08 | Kyowa Hakko Kogyo Co Ltd | マイトマイシン誘導体 |
JPH06335575A (ja) * | 1993-05-28 | 1994-12-06 | Tokyo Electric Co Ltd | 電気かみそり |
-
1989
- 1989-07-25 JP JP1508792A patent/JPH04500513A/ja active Pending
- 1989-07-25 KR KR1019900700816A patent/KR900701269A/ko not_active Application Discontinuation
- 1989-07-25 AU AU40650/89A patent/AU628846B2/en not_active Ceased
- 1989-07-25 WO PCT/US1989/003180 patent/WO1990001931A1/en not_active Application Discontinuation
- 1989-07-25 EP EP19890909473 patent/EP0431008A4/en not_active Withdrawn
- 1989-08-08 ZA ZA896025A patent/ZA896025B/xx unknown
- 1989-08-16 IL IL91332A patent/IL91332A0/xx unknown
- 1989-08-17 NZ NZ230343A patent/NZ230343A/en unknown
- 1989-08-18 GR GR890100514A patent/GR1000785B/el unknown
- 1989-08-21 PT PT91499A patent/PT91499B/pt not_active IP Right Cessation
- 1989-08-22 IE IE269189A patent/IE63036B1/en not_active IP Right Cessation
- 1989-08-22 CN CN89106432A patent/CN1040593A/zh active Pending
- 1989-08-22 ES ES8902910A patent/ES2018726A6/es not_active Expired - Lifetime
- 1989-08-22 CA CA000608960A patent/CA1327037C/en not_active Expired - Fee Related
-
1991
- 1991-02-19 NO NO910662A patent/NO177673C/no unknown
- 1991-02-20 DK DK029691A patent/DK29691A/da not_active Application Discontinuation
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS601197A (ja) * | 1983-06-17 | 1985-01-07 | Kyowa Hakko Kogyo Co Ltd | マイトマイシン誘導体 |
WO1986007260A1 (en) * | 1985-06-06 | 1986-12-18 | Georgetown University | 1a-7-SUBSTITUTED DERIVATIVES OF MITOMYCIN AND USES THEREOF |
JPS63246336A (ja) * | 1986-11-10 | 1988-10-13 | Kyowa Hakko Kogyo Co Ltd | マイトマイシン−抗体複合体含有組成物 |
Non-Patent Citations (3)
Title |
---|
CLAIMS SEARCHED: ALL * |
PATENT ABSTRACTS OF JAPAN, vol. 13, no. 49 (C-565)[3397], 3rd February 1989; & JP-A-63 246 336 (KYOWA HAKKO KOGYO CO., LTD) 13-10-1988 * |
PATENT ABSTRACTS OF JAPAN, vol. 9, no. 108 (C-280)[1831], 11th May 1985; & JP-A-60 001 197 (KYOWA HAKKO KOGYO K.K.) 07-01-1985 * |
Also Published As
Publication number | Publication date |
---|---|
EP0431008A4 (en) | 1992-03-11 |
ZA896025B (en) | 1990-05-30 |
GR1000785B (el) | 1992-12-30 |
CA1327037C (en) | 1994-02-15 |
NZ230343A (en) | 1992-01-29 |
NO177673B (no) | 1995-07-24 |
AU628846B2 (en) | 1992-09-24 |
IL91332A0 (en) | 1990-03-19 |
CN1040593A (zh) | 1990-03-21 |
IE63036B1 (en) | 1995-03-22 |
AU4065089A (en) | 1990-03-23 |
JPH04500513A (ja) | 1992-01-30 |
EP0431008A1 (en) | 1991-06-12 |
IE892691L (en) | 1990-02-23 |
WO1990001931A1 (en) | 1990-03-08 |
PT91499A (pt) | 1990-03-08 |
DK29691A (da) | 1991-04-23 |
NO910662D0 (no) | 1991-02-19 |
DK29691D0 (da) | 1991-02-20 |
NO177673C (no) | 1995-11-01 |
PT91499B (pt) | 1995-07-06 |
NO910662L (no) | 1991-03-21 |
ES2018726A6 (es) | 1991-05-01 |
KR900701269A (ko) | 1990-12-01 |
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