GR890100514A - Processes for the preparation of mitomycin derivatives having reduced bone marrow toxicity - Google Patents

Processes for the preparation of mitomycin derivatives having reduced bone marrow toxicity

Info

Publication number
GR890100514A
GR890100514A GR89100514A GR890100514A GR890100514A GR 890100514 A GR890100514 A GR 890100514A GR 89100514 A GR89100514 A GR 89100514A GR 890100514 A GR890100514 A GR 890100514A GR 890100514 A GR890100514 A GR 890100514A
Authority
GR
Greece
Prior art keywords
processes
preparation
bone marrow
reduced bone
marrow toxicity
Prior art date
Application number
GR89100514A
Other languages
English (en)
Other versions
GR1000785B (el
Inventor
Abdolhossen Talebian
Diana Green
Charles Hammer
Philip Schein
Original Assignee
Univ Georgetown
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Georgetown filed Critical Univ Georgetown
Publication of GR890100514A publication Critical patent/GR890100514A/el
Publication of GR1000785B publication Critical patent/GR1000785B/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
GR890100514A 1988-08-23 1989-08-18 Μεθοδοι παρασκευης παραγωγων μιτομυκινης που εχουν μειωμενη τοξικοτητα μυελου των οστων GR1000785B (el)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US23522488A 1988-08-23 1988-08-23

Publications (2)

Publication Number Publication Date
GR890100514A true GR890100514A (en) 1991-12-30
GR1000785B GR1000785B (el) 1992-12-30

Family

ID=22884628

Family Applications (1)

Application Number Title Priority Date Filing Date
GR890100514A GR1000785B (el) 1988-08-23 1989-08-18 Μεθοδοι παρασκευης παραγωγων μιτομυκινης που εχουν μειωμενη τοξικοτητα μυελου των οστων

Country Status (16)

Country Link
EP (1) EP0431008A4 (el)
JP (1) JPH04500513A (el)
KR (1) KR900701269A (el)
CN (1) CN1040593A (el)
AU (1) AU628846B2 (el)
CA (1) CA1327037C (el)
DK (1) DK29691A (el)
ES (1) ES2018726A6 (el)
GR (1) GR1000785B (el)
IE (1) IE63036B1 (el)
IL (1) IL91332A0 (el)
NO (1) NO177673C (el)
NZ (1) NZ230343A (el)
PT (1) PT91499B (el)
WO (1) WO1990001931A1 (el)
ZA (1) ZA896025B (el)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5091523A (en) * 1990-04-25 1992-02-25 Georgetown University Mitomycin derivatives having reduced bone marrow toxicity, processes for their preparation, and the uses thereof
EP0485904B1 (en) * 1990-11-13 1997-08-20 Kyowa Hakko Kogyo Co., Ltd. Mitomycin derivatives
GB2282384B8 (en) * 1993-08-18 1997-09-04 Europ Economic Community Drug delivery agents incorporating mitomycin
CN104231045B (zh) * 2014-08-22 2017-10-31 亚飞（上海）生物医药科技有限公司 一种靶向激活释放的丝裂霉素衍生物及其用途
JP6854759B2 (ja) 2014-08-22 2021-04-07 ヤフェイ シャンハイ バイオログ メディスン サイエンス アンド テクノロジー カンパニー リミテッド 腫瘍微環境によって特異的活性化する小分子標的結合体およびその使用
US9801909B2 (en) 2015-04-06 2017-10-31 The Penn State Research Foundation Compositions and methods for combating bacterial infections by killing persister cells with mitomycin C

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS601197A (ja) * 1983-06-17 1985-01-07 Kyowa Hakko Kogyo Co Ltd マイトマイシン誘導体
WO1986007260A1 (en) * 1985-06-06 1986-12-18 Georgetown University 1a-7-SUBSTITUTED DERIVATIVES OF MITOMYCIN AND USES THEREOF
JPS63246336A (ja) * 1986-11-10 1988-10-13 Kyowa Hakko Kogyo Co Ltd マイトマイシン−抗体複合体含有組成物

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US479130A (en) * 1892-07-19 Rudolf allert
US3226393A (en) * 1962-06-07 1965-12-28 American Cyanamid Co N-substituted derivatives of mitomycin a and mitomycin c
DE1570029A1 (de) * 1964-07-09 1970-04-09 Kyowa Hakko Kogyo Kk Verfahren zur Herstellung von Mitosanverbindungen
US3367945A (en) * 1965-05-18 1968-02-06 Kyowa Hakko Kogyo Kk Thiourea derivatives of mitomycin
JPS5240B2 (el) * 1973-12-17 1977-01-05
JPS5630978A (en) * 1979-08-24 1981-03-28 Kyowa Hakko Kogyo Co Ltd Novel mitomycin and its preparation
US4268676A (en) * 1979-12-05 1981-05-19 University Patents, Inc. Mitomycin analogs
US4746746A (en) * 1983-02-07 1988-05-24 University Patents, Inc. Mitomycin analogs
US4814445A (en) * 1984-09-04 1989-03-21 Bristol-Myers Company Process for preparing mitomycin analogs
DE3674043D1 (de) * 1985-04-10 1990-10-18 Kyowa Hakko Kogyo Kk Pharmakologisch aktive mitomycinderivate.
JPS6354380A (ja) * 1986-08-26 1988-03-08 Kyowa Hakko Kogyo Co Ltd マイトマイシン誘導体
JPH06335575A (ja) * 1993-05-28 1994-12-06 Tokyo Electric Co Ltd 電気かみそり

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS601197A (ja) * 1983-06-17 1985-01-07 Kyowa Hakko Kogyo Co Ltd マイトマイシン誘導体
WO1986007260A1 (en) * 1985-06-06 1986-12-18 Georgetown University 1a-7-SUBSTITUTED DERIVATIVES OF MITOMYCIN AND USES THEREOF
JPS63246336A (ja) * 1986-11-10 1988-10-13 Kyowa Hakko Kogyo Co Ltd マイトマイシン−抗体複合体含有組成物

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CLAIMS SEARCHED: ALL *
PATENT ABSTRACTS OF JAPAN, vol. 13, no. 49 (C-565)[3397], 3rd February 1989; & JP-A-63 246 336 (KYOWA HAKKO KOGYO CO., LTD) 13-10-1988 *
PATENT ABSTRACTS OF JAPAN, vol. 9, no. 108 (C-280)[1831], 11th May 1985; & JP-A-60 001 197 (KYOWA HAKKO KOGYO K.K.) 07-01-1985 *

Also Published As

Publication number Publication date
EP0431008A4 (en) 1992-03-11
ZA896025B (en) 1990-05-30
GR1000785B (el) 1992-12-30
CA1327037C (en) 1994-02-15
NZ230343A (en) 1992-01-29
NO177673B (no) 1995-07-24
AU628846B2 (en) 1992-09-24
IL91332A0 (en) 1990-03-19
CN1040593A (zh) 1990-03-21
IE63036B1 (en) 1995-03-22
AU4065089A (en) 1990-03-23
JPH04500513A (ja) 1992-01-30
EP0431008A1 (en) 1991-06-12
IE892691L (en) 1990-02-23
WO1990001931A1 (en) 1990-03-08
PT91499A (pt) 1990-03-08
DK29691A (da) 1991-04-23
NO910662D0 (no) 1991-02-19
DK29691D0 (da) 1991-02-20
NO177673C (no) 1995-11-01
PT91499B (pt) 1995-07-06
NO910662L (no) 1991-03-21
ES2018726A6 (es) 1991-05-01
KR900701269A (ko) 1990-12-01

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