GR880100602A - Water soluble monoesters as solubilisers for pharmacologically active compounds and pharmaceutical excipients - Google Patents

Water soluble monoesters as solubilisers for pharmacologically active compounds and pharmaceutical excipients

Info

Publication number
GR880100602A
GR880100602A GR880100602A GR880100602A GR880100602A GR 880100602 A GR880100602 A GR 880100602A GR 880100602 A GR880100602 A GR 880100602A GR 880100602 A GR880100602 A GR 880100602A GR 880100602 A GR880100602 A GR 880100602A
Authority
GR
Greece
Prior art keywords
active compounds
pharmacologically active
solubilisers
water soluble
pharmaceutical excipients
Prior art date
Application number
GR880100602A
Other languages
Greek (el)
Other versions
GR1002243B (en
Inventor
Lorenz Hahn
Original Assignee
Sandoz Ag
Sandoz Sa
Sandoz Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Ag, Sandoz Sa, Sandoz Ltd filed Critical Sandoz Ag
Publication of GR880100602A publication Critical patent/GR880100602A/en
Publication of GR1002243B publication Critical patent/GR1002243B/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner

Abstract

Ενας συνδυασμός μιας φαρμακολογικώς δραστικής ενώσεως και ενός υδατοδιαλυτού μονοεστέρος ενός κεκορεσμένου ή ακορέστου (C6-18) λιπαρού οξέος και μιας πολυόλης, ειδικώς ενός σακχαρίτου και ιδιαιτέρως ως ένα στερεόν διάλυμα της δραστικής ενώσεως του μονοεστέρος. Το στερεόν διάλυμα είναι ειδικώς κατάλληλον δια ουσιαστικώς, αδιαλύτους εις το υδωρ δραστικάς ενώσεις και ιδιαιτέρως δια πολυπεπτίδια τοιαύτα όπως π.χ. κυκλοσπορίνας και/ή μπορεί εις όλας τας επι?υμητάς αναλογίας βάρους να αναμιχ?εί με ύδωρ. ωA combination of a pharmacologically active compound and an aqueous soluble monoestrate of a saturated or unsaturated (C6-18) fatty acid and a polyol, specifically a saccharin, and in particular as a solid solution of the active monosaccharide compound. The solid solution is specially suitable for essentially insoluble in water active compounds and especially for polypeptides such as e.g. cyclosporine and / or may in all elongated weight ratios be mixed with water. ω

GR880100602A 1987-09-15 1988-09-14 Water soluble monoesters as solubilisers for pharmacologically active compounds and pharmaceutical excipients. GR1002243B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3730909 1987-09-15
DE3802355 1988-01-27

Publications (2)

Publication Number Publication Date
GR880100602A true GR880100602A (en) 1989-06-22
GR1002243B GR1002243B (en) 1996-04-22

Family

ID=25859774

Family Applications (1)

Application Number Title Priority Date Filing Date
GR880100602A GR1002243B (en) 1987-09-15 1988-09-14 Water soluble monoesters as solubilisers for pharmacologically active compounds and pharmaceutical excipients.

Country Status (24)

Country Link
JP (1) JP3090666B2 (en)
KR (1) KR0131084B1 (en)
AT (1) AT395819B (en)
AU (1) AU628787B2 (en)
BE (1) BE1001204A5 (en)
CA (1) CA1338775C (en)
CH (1) CH683672A5 (en)
DK (1) DK175132B1 (en)
ES (1) ES2012118A6 (en)
FI (1) FI94837C (en)
FR (1) FR2620336B1 (en)
GB (1) GB2209671B (en)
GR (1) GR1002243B (en)
HU (1) HU205010B (en)
IE (1) IE61195B1 (en)
IL (1) IL87746A (en)
IT (1) IT1224886B (en)
LU (1) LU87335A1 (en)
MY (1) MY103769A (en)
NL (1) NL195094C (en)
NO (1) NO179434C (en)
NZ (1) NZ226163A (en)
PT (1) PT88492B (en)
SE (1) SE503279C2 (en)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR0148748B1 (en) * 1988-09-16 1998-08-17 장 크라메르, 한스 루돌프 하우스 A multiphase cyclosporin composition
US6007840A (en) * 1988-09-16 1999-12-28 Novartis Ag Pharmaceutical compositions comprising cyclosporins
GR1000466B (en) * 1989-01-28 1992-07-30 Sandoz Ag Preparation method of novel pharmaceutical forms of cyclosporine
CH679277A5 (en) * 1989-02-09 1992-01-31 Sandoz Ag
GB8916901D0 (en) 1989-07-24 1989-09-06 Sandoz Ltd Improvements in or relating to organic compounds
US6262022B1 (en) 1992-06-25 2001-07-17 Novartis Ag Pharmaceutical compositions containing cyclosporin as the active agent
SG45449A1 (en) 1992-05-13 1998-01-16 Sandoz Ltd Ophthalmic compositions
PT589843E (en) 1992-09-25 2002-04-29 Novartis Ag PHARMACEUTICAL COMPOSITIONS CONTAINING CYCLOSPORTS
EP1029538A3 (en) 1993-09-28 2003-10-15 R.P. Scherer GmbH Soft gelatin capsule manufacture
PT789580E (en) 1994-11-03 2002-09-30 Novartis Ag CYCLOSPORINE FORMULATIONS FOR ORAL ADMINISTRATION WITH SIMPLE COMPOSITION AND HIGH BIODISPONIBILITY AND PROCESS FOR ITS PRODUCTION
US5766629A (en) 1995-08-25 1998-06-16 Sangstat Medical Corporation Oral cyclosporin formulations
US5962019A (en) * 1995-08-25 1999-10-05 Sangstat Medical Corporation Oral cyclosporin formulations
US5834017A (en) * 1995-08-25 1998-11-10 Sangstat Medical Corporation Oral cyclopsporin formulations
US5827822A (en) * 1996-03-25 1998-10-27 Sangstat Medical Corporation Cyclosporin a formulations as nanoparticles
DE19544507B4 (en) 1995-11-29 2007-11-15 Novartis Ag Cyclosporin containing preparations
TW414696B (en) * 1996-07-01 2000-12-11 Mitsubishi Kagaku Foods Kk Anti-bacteria agent
RU2211047C2 (en) 1997-01-30 2003-08-27 Новартис Аг Gelatin capsule with solid film including oil-free pharmaceutically compositions
GB2326337A (en) * 1997-06-20 1998-12-23 Phares Pharma Holland Homogeneous lipid compositions for drug delivery
US7732404B2 (en) 1999-12-30 2010-06-08 Dexcel Ltd Pro-nanodispersion for the delivery of cyclosporin
WO2005037252A1 (en) * 2003-10-14 2005-04-28 Wockhardt Limited Sterile gelling agents
JP5422871B2 (en) * 2006-10-24 2014-02-19 不二製油株式会社 Isoflavones composition

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR5986M (en) * 1966-11-22 1968-06-21
CH497898A (en) * 1961-10-31 1970-10-31 Bayer Ag Solubilisers for narcotically-active phenoxyacetic acid
DE1617557A1 (en) * 1966-05-12 1971-04-01 Suga Kazuo Stable oryzanole solution and process for making same
DE2241667B2 (en) * 1971-08-25 1974-09-19 Sumitomo Chemical Co., Ltd., Osaka (Japan) Stable pharmaceutical agent in the form of an aqueous oral suspension
FR2381520A1 (en) * 1977-02-28 1978-09-22 Yamanouchi Pharma Co Ltd COMPOSITIONS FOR RECTAL USE
GB2015339A (en) * 1978-03-07 1979-09-12 Sandoz Ltd Compositions comprising mono-cyclic peptides
EP0057462A2 (en) * 1981-02-03 1982-08-11 Eisai Co., Ltd. Elastase-containing composition permitting elastase to be absorbed in increased amount
EP0179583A1 (en) * 1984-10-04 1986-04-30 Merck & Co. Inc. A system for enhancing the water dissolution rate and solubility of poorly soluble drugs

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61280435A (en) * 1985-04-04 1986-12-11 Kanji Takada Lymph orienting preparation of cyclosporin

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH497898A (en) * 1961-10-31 1970-10-31 Bayer Ag Solubilisers for narcotically-active phenoxyacetic acid
DE1617557A1 (en) * 1966-05-12 1971-04-01 Suga Kazuo Stable oryzanole solution and process for making same
FR5986M (en) * 1966-11-22 1968-06-21
DE2241667B2 (en) * 1971-08-25 1974-09-19 Sumitomo Chemical Co., Ltd., Osaka (Japan) Stable pharmaceutical agent in the form of an aqueous oral suspension
FR2381520A1 (en) * 1977-02-28 1978-09-22 Yamanouchi Pharma Co Ltd COMPOSITIONS FOR RECTAL USE
GB2015339A (en) * 1978-03-07 1979-09-12 Sandoz Ltd Compositions comprising mono-cyclic peptides
EP0057462A2 (en) * 1981-02-03 1982-08-11 Eisai Co., Ltd. Elastase-containing composition permitting elastase to be absorbed in increased amount
EP0179583A1 (en) * 1984-10-04 1986-04-30 Merck & Co. Inc. A system for enhancing the water dissolution rate and solubility of poorly soluble drugs

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CLAIMS SEARCHED: ALL *
DERWENT FILE SUPPLIER, WPI(L), 1981, accession no. 81-88539D[48], Derwent Publications Ltd, London, GB; & Res. Disclosure 211032 (ANON.) 10-11-1981 *

Also Published As

Publication number Publication date
GB2209671A (en) 1989-05-24
FR2620336A1 (en) 1989-03-17
DK511188A (en) 1989-03-16
NO884052D0 (en) 1988-09-13
LU87335A1 (en) 1989-04-06
FR2620336B1 (en) 1991-10-25
DK175132B1 (en) 2004-06-14
KR890004694A (en) 1989-05-09
MY103769A (en) 1993-09-30
IE61195B1 (en) 1994-10-19
CA1338775C (en) 1996-12-10
AU628787B2 (en) 1992-09-24
AT395819B (en) 1993-03-25
NL8802275A (en) 1989-04-03
HU205010B (en) 1992-03-30
FI94837B (en) 1995-07-31
ES2012118A6 (en) 1990-03-01
AU2217288A (en) 1989-04-27
FI884192A0 (en) 1988-09-13
FI94837C (en) 1995-11-10
IT8848349A0 (en) 1988-09-14
NO884052L (en) 1989-03-16
GB8821443D0 (en) 1988-10-12
CH683672A5 (en) 1994-04-29
BE1001204A5 (en) 1989-08-16
PT88492A (en) 1988-10-01
NO179434B (en) 1996-07-01
ATA224988A (en) 1992-08-15
GB2209671B (en) 1991-11-13
FI884192A (en) 1989-03-16
HUT49494A (en) 1989-10-30
NO179434C (en) 1996-10-09
PT88492B (en) 1993-03-31
JP3090666B2 (en) 2000-09-25
IL87746A (en) 1992-07-15
DK511188D0 (en) 1988-09-14
SE8803221L (en) 1989-03-16
IE882772L (en) 1989-03-15
GR1002243B (en) 1996-04-22
SE503279C2 (en) 1996-05-13
NL195094C (en) 2003-12-17
SE8803221D0 (en) 1988-09-13
IT1224886B (en) 1990-10-24
NZ226163A (en) 1991-08-27
IL87746A0 (en) 1989-02-28
KR0131084B1 (en) 1998-04-17
JPH01151526A (en) 1989-06-14

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