SE8803221D0 - WATER SOLUBLE MONOESTERS AS SOLUBILIZERS FOR PHARMACOLOGICALLY ACTIVE COMPOUNDS AND PHARMACEUTICAL EXCIPIENTS - Google Patents

WATER SOLUBLE MONOESTERS AS SOLUBILIZERS FOR PHARMACOLOGICALLY ACTIVE COMPOUNDS AND PHARMACEUTICAL EXCIPIENTS

Info

Publication number
SE8803221D0
SE8803221D0 SE8803221A SE8803221A SE8803221D0 SE 8803221 D0 SE8803221 D0 SE 8803221D0 SE 8803221 A SE8803221 A SE 8803221A SE 8803221 A SE8803221 A SE 8803221A SE 8803221 D0 SE8803221 D0 SE 8803221D0
Authority
SE
Sweden
Prior art keywords
water soluble
active compounds
pharmacologically active
solubilizers
pharmaceutical excipients
Prior art date
Application number
SE8803221A
Other languages
Swedish (sv)
Other versions
SE8803221L (en
SE503279C2 (en
Inventor
L Hahn
Original Assignee
Sandoz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Ag filed Critical Sandoz Ag
Publication of SE8803221D0 publication Critical patent/SE8803221D0/en
Publication of SE8803221L publication Critical patent/SE8803221L/en
Publication of SE503279C2 publication Critical patent/SE503279C2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A combination of a pharmacologically active compound and a water soluble monoester of a saturated or unsaturated (C6-18) fatty acid and a polyol, especially a saccharide, particularly as a solid solution of the active compound in the monoester. The solid solution is especially suitable for substantially water insoluble active compounds, particularly such polypeptides, e.g. ciclosporins and is in all desirable weight ratios miscible with water.
SE8803221A 1987-09-15 1988-09-13 Water-soluble monoesters as solubilizers for pharmacologically active compounds and pharmaceutical excipients SE503279C2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3730909 1987-09-15
DE3802355 1988-01-27

Publications (3)

Publication Number Publication Date
SE8803221D0 true SE8803221D0 (en) 1988-09-13
SE8803221L SE8803221L (en) 1989-03-16
SE503279C2 SE503279C2 (en) 1996-05-13

Family

ID=25859774

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8803221A SE503279C2 (en) 1987-09-15 1988-09-13 Water-soluble monoesters as solubilizers for pharmacologically active compounds and pharmaceutical excipients

Country Status (24)

Country Link
JP (1) JP3090666B2 (en)
KR (1) KR0131084B1 (en)
AT (1) AT395819B (en)
AU (1) AU628787B2 (en)
BE (1) BE1001204A5 (en)
CA (1) CA1338775C (en)
CH (1) CH683672A5 (en)
DK (1) DK175132B1 (en)
ES (1) ES2012118A6 (en)
FI (1) FI94837C (en)
FR (1) FR2620336B1 (en)
GB (1) GB2209671B (en)
GR (1) GR1002243B (en)
HU (1) HU205010B (en)
IE (1) IE61195B1 (en)
IL (1) IL87746A (en)
IT (1) IT1224886B (en)
LU (1) LU87335A1 (en)
MY (1) MY103769A (en)
NL (1) NL195094C (en)
NO (1) NO179434C (en)
NZ (1) NZ226163A (en)
PT (1) PT88492B (en)
SE (1) SE503279C2 (en)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2222770B (en) * 1988-09-16 1992-07-29 Sandoz Ltd Pharmaceutical compositions containing cyclosporins
US6007840A (en) * 1988-09-16 1999-12-28 Novartis Ag Pharmaceutical compositions comprising cyclosporins
GR1000466B (en) * 1989-01-28 1992-07-30 Sandoz Ag Preparation method of novel pharmaceutical forms of cyclosporine
BE1003009A5 (en) * 1989-02-09 1991-10-22 Sandoz Sa NOVEL PHARMACEUTICAL COMPOSITIONS BASED ON CYCLOSPORINS.
GB8916901D0 (en) 1989-07-24 1989-09-06 Sandoz Ltd Improvements in or relating to organic compounds
US6262022B1 (en) 1992-06-25 2001-07-17 Novartis Ag Pharmaceutical compositions containing cyclosporin as the active agent
EP0642332B1 (en) 1992-05-13 1997-01-15 Sandoz Ltd. Ophthalmic compositions containing a cyclosporin
EP1142568A1 (en) 1992-09-25 2001-10-10 Novartis AG Pharmaceutical compositions containing cyclosporins
SI1033128T2 (en) 1993-09-28 2012-02-29 Scherer Gmbh R P Soft gelatin capsule manufacture
RU2158601C2 (en) 1994-11-03 2000-11-10 Новартис Аг Novel medicinal forms of cyclosporine for oral administration having simple formulation and bioavailability, and method of preparation thereof
US5834017A (en) * 1995-08-25 1998-11-10 Sangstat Medical Corporation Oral cyclopsporin formulations
US5766629A (en) * 1995-08-25 1998-06-16 Sangstat Medical Corporation Oral cyclosporin formulations
US5827822A (en) * 1996-03-25 1998-10-27 Sangstat Medical Corporation Cyclosporin a formulations as nanoparticles
US5962019A (en) * 1995-08-25 1999-10-05 Sangstat Medical Corporation Oral cyclosporin formulations
DE19549852B4 (en) 1995-11-29 2009-06-04 Novartis Ag Cyclosporin containing preparations
TW414696B (en) * 1996-07-01 2000-12-11 Mitsubishi Kagaku Foods Kk Anti-bacteria agent
SK285019B6 (en) 1997-01-30 2006-04-06 Novartis Ag Hard gelatine capsule
GB2326337A (en) * 1997-06-20 1998-12-23 Phares Pharma Holland Homogeneous lipid compositions for drug delivery
US7732404B2 (en) 1999-12-30 2010-06-08 Dexcel Ltd Pro-nanodispersion for the delivery of cyclosporin
EP1558215A4 (en) * 2003-10-14 2007-09-12 Wockhardt Ltd Sterile gelling agents
JP5422871B2 (en) * 2006-10-24 2014-02-19 不二製油株式会社 Isoflavones composition

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL284933A (en) * 1961-10-31
GB1134878A (en) * 1966-05-12 1968-11-27 Suga Kazuo Improvements in and relating to oryzanol solutions and compositions
FR5986M (en) * 1966-11-22 1968-06-21
BE787842A (en) * 1971-08-25 1972-12-18 Sumito Chemical Cy Ltd PROCESS FOR PREPARING AN AQUEOUS SUSPENSION OF STABLE CRYSTALS OF THE NON-BETA TYPE OF HIGHER FATTY ACID ESTERS OF CHLORAMPHENICOL
JPS53107408A (en) * 1977-02-28 1978-09-19 Yamanouchi Pharmaceut Co Ltd Micellar preparation for rectal infusion
FI65914C (en) * 1978-03-07 1984-08-10 Sandoz Ag FRAMEWORK FOR PHARMACEUTICAL COMPOSITION OF CYCLOSPORINE A
JPS57128634A (en) * 1981-02-03 1982-08-10 Eisai Co Ltd Elastase-containing compound increasing absorption
EP0179583A1 (en) * 1984-10-04 1986-04-30 Merck & Co. Inc. A system for enhancing the water dissolution rate and solubility of poorly soluble drugs
JPS61280435A (en) * 1985-04-04 1986-12-11 Kanji Takada Lymph orienting preparation of cyclosporin

Also Published As

Publication number Publication date
GR880100602A (en) 1989-06-22
AU2217288A (en) 1989-04-27
NL8802275A (en) 1989-04-03
PT88492B (en) 1993-03-31
FI94837B (en) 1995-07-31
DK511188D0 (en) 1988-09-14
FI94837C (en) 1995-11-10
ES2012118A6 (en) 1990-03-01
GB2209671A (en) 1989-05-24
AT395819B (en) 1993-03-25
FR2620336B1 (en) 1991-10-25
NO179434B (en) 1996-07-01
IL87746A0 (en) 1989-02-28
GB8821443D0 (en) 1988-10-12
GR1002243B (en) 1996-04-22
CH683672A5 (en) 1994-04-29
IL87746A (en) 1992-07-15
LU87335A1 (en) 1989-04-06
IE61195B1 (en) 1994-10-19
NO179434C (en) 1996-10-09
IE882772L (en) 1989-03-15
KR0131084B1 (en) 1998-04-17
SE8803221L (en) 1989-03-16
HUT49494A (en) 1989-10-30
HU205010B (en) 1992-03-30
JP3090666B2 (en) 2000-09-25
KR890004694A (en) 1989-05-09
NL195094C (en) 2003-12-17
CA1338775C (en) 1996-12-10
PT88492A (en) 1988-10-01
AU628787B2 (en) 1992-09-24
DK175132B1 (en) 2004-06-14
DK511188A (en) 1989-03-16
FI884192A0 (en) 1988-09-13
IT1224886B (en) 1990-10-24
ATA224988A (en) 1992-08-15
NO884052L (en) 1989-03-16
NO884052D0 (en) 1988-09-13
GB2209671B (en) 1991-11-13
BE1001204A5 (en) 1989-08-16
FR2620336A1 (en) 1989-03-17
IT8848349A0 (en) 1988-09-14
SE503279C2 (en) 1996-05-13
MY103769A (en) 1993-09-30
NZ226163A (en) 1991-08-27
JPH01151526A (en) 1989-06-14
FI884192A (en) 1989-03-16

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