GR82243B - - Google Patents
Info
- Publication number
- GR82243B GR82243B GR75233A GR840175233A GR82243B GR 82243 B GR82243 B GR 82243B GR 75233 A GR75233 A GR 75233A GR 840175233 A GR840175233 A GR 840175233A GR 82243 B GR82243 B GR 82243B
- Authority
- GR
- Greece
- Prior art keywords
- compounds
- elgins
- eglins
- eglin
- novel
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 abstract 2
- 108010031145 eglin proteinase inhibitors Proteins 0.000 abstract 1
- 230000002255 enzymatic effect Effects 0.000 abstract 1
- 230000004048 modification Effects 0.000 abstract 1
- 238000012986 modification Methods 0.000 abstract 1
- 238000010647 peptide synthesis reaction Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 230000017854 proteolysis Effects 0.000 abstract 1
- 238000004904 shortening Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Rheumatology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Pain & Pain Management (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Paper (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3324534A DE3324534A1 (de) | 1983-07-07 | 1983-07-07 | Modifizierte protease-inhibitoren, verfahren zu ihrer herstellung und daraus bereitete pharmazeutische mittel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GR82243B true GR82243B (en, 2012) | 1984-12-13 |
Family
ID=6203414
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GR75233A GR82243B (en, 2012) | 1983-07-07 | 1984-07-06 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US4636489A (en, 2012) |
| EP (1) | EP0134479B1 (en, 2012) |
| JP (1) | JPH0670077B2 (en, 2012) |
| AT (1) | ATE32728T1 (en, 2012) |
| CA (1) | CA1230069A (en, 2012) |
| DE (2) | DE3324534A1 (en, 2012) |
| DK (1) | DK165988C (en, 2012) |
| ES (1) | ES534098A0 (en, 2012) |
| GR (1) | GR82243B (en, 2012) |
| IE (1) | IE57698B1 (en, 2012) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6342373B1 (en) * | 1983-11-21 | 2002-01-29 | Ucp Gen-Pharma Ag | Process for preparing recombinant eglin, protease inhibitor |
| DE3506992A1 (de) * | 1985-02-27 | 1986-08-28 | Plantorgan Werk Heinrich G.E. Christensen, KG, 2903 Bad Zwischenahn | Modifizierte hirudine, verfahren zu deren herstellung und pharmazeutische mittel, die diese wirkstoffe enthalten |
| US5166134A (en) * | 1986-12-24 | 1992-11-24 | John Lezdey | Treatment of allergic rhinitis |
| EP0332576B1 (de) * | 1988-03-07 | 1994-04-06 | Ciba-Geigy Ag | Modifizierte Proteine |
| US5180667A (en) * | 1988-03-07 | 1993-01-19 | Ciba-Geigy Corporation | Genes encoding eglin C mutants |
| US5114921A (en) * | 1988-05-27 | 1992-05-19 | The Children's Hospital Of Philadelphia | Amphiphilic peptides and use thereof |
| ATE115146T1 (de) * | 1988-05-27 | 1994-12-15 | Philadelphia Children Hospital | Amphiphile peptide und deren verwendung. |
| US5268296A (en) * | 1988-06-11 | 1993-12-07 | Ciba-Geigy Corporation | DNA vector and recombinant host cell for production of hirullin P6 and P18 |
| DE58907266T2 (de) * | 1988-06-11 | 1994-09-29 | Ciba Geigy Ag | Polypeptide mit einer die Koagulierung hemmenden Wirkung. |
| US5254535A (en) * | 1989-04-17 | 1993-10-19 | The Children's Hospital Of Pennsylvania | Composition and treatment with biologically active peptides and antibiotic |
| EP0514464A4 (en) * | 1990-02-08 | 1993-04-28 | Magainin Sciences, Inc. | Biologically active amphiphilic peptides and method of inhibiting growth of target cells, virus or virally-infected cell |
| US5459237A (en) * | 1990-02-08 | 1995-10-17 | Magainin Pharmaceuticals Inc. | Peptide compositions and uses therefor |
| US5792831A (en) * | 1990-02-08 | 1998-08-11 | Magainin Pharmaceuticals Inc. | Analogues of magainin peptides containing D-amino acids |
| EP0533795A4 (en) * | 1990-05-14 | 1993-10-20 | Magainin Sciences, Inc. | Composition of and treatment with biologically active peptides having d-amino acid residues |
| US5208220A (en) * | 1990-06-27 | 1993-05-04 | Magainin Pharmaceuticals, Inc. | Composition and treatment with biologically active peptides and antibiotics which inhibit DNA gyrase |
| WO1992000090A1 (en) * | 1990-06-27 | 1992-01-09 | Magainin Pharmaceuticals Inc. | Composition and treatment with biologically active peptides and antibiotics which inhibit dna gyrase |
| HU217612B (hu) * | 1991-05-23 | 2000-03-28 | Merrel Dow Pharmaceuticals Inc. | Eljárás elasztáz és katepszin G inhibitor hatású peptidek előállítására |
| US5478811A (en) * | 1991-08-22 | 1995-12-26 | Merrell Dow Pharmaceuticals Inc. | Orally-active elastase inhibitors |
| US5714470A (en) * | 1991-08-22 | 1998-02-03 | Merrell Pharmaceuticals, Inc. | Orally-active elastase inhibitors |
| JPH07500342A (ja) * | 1991-10-16 | 1995-01-12 | ザ・チルドレンズ・ホスピタル・オブ・フィラデルフィア | 生物学的活性ペプチドおよび抗生物質を有する組成物およびこれを用いた治療 |
| CA2191844C (en) * | 1994-06-02 | 2001-07-24 | Norton P. Peet | Acylated enol derivatives as prodrugs of elastase inhibitors |
| FI964789A0 (fi) * | 1994-06-02 | 1996-11-29 | Merrell Pharma Inc | Elastaasin pefluorialkyyliketoni-inhibiittoreita ja menetelmiä niiden valmistamiseksi |
| US5948886A (en) * | 1996-11-20 | 1999-09-07 | Hoechst Marion Roussel, Inc. | Acylated enol derivatives of α-ketoesters and α-ketoamides |
| US6172044B1 (en) | 1995-12-01 | 2001-01-09 | Aventis Pharmaceuticals Inc. | Acylated enol derivative of α-ketoesters and α-ketoamides |
| DK0929577T3 (da) | 1996-09-24 | 2003-10-06 | Procter & Gamble | Stabiliserede proteinholdige protease-inhibitorer og varianter deraf |
| US7001884B2 (en) * | 2001-06-18 | 2006-02-21 | Regents Of The University Of Michigan | Eglin c based drugs for treatment of disease |
| DE102005007313A1 (de) * | 2005-02-17 | 2006-08-24 | Wacker Chemie Ag | Verfahren zur Herstellung von Entschäumerformulierungen |
| KR101237116B1 (ko) * | 2010-11-12 | 2013-02-25 | 대한유화공업 주식회사 | 내충격성 및 내압특성이 우수한 폴리프로필렌 조성물 |
| CN110551707A (zh) * | 2019-10-17 | 2019-12-10 | 山西大学 | 一种纯化中性或碱性蛋白酶的方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2808396C2 (de) * | 1978-02-27 | 1984-04-19 | Plantorgan Werk Heinrich G.E. Christensen, KG, 2903 Bad Zwischenahn | Protease-Inhibitoren |
| US4250086A (en) * | 1979-11-19 | 1981-02-10 | Ortho Pharmaceutical Corporation | Method and composition for preparation of H-SAR-LYS-SAR-GLN-NH2 |
-
1983
- 1983-07-07 DE DE3324534A patent/DE3324534A1/de not_active Withdrawn
-
1984
- 1984-07-05 EP EP84107861A patent/EP0134479B1/de not_active Expired
- 1984-07-05 CA CA000458165A patent/CA1230069A/en not_active Expired
- 1984-07-05 AT AT84107861T patent/ATE32728T1/de not_active IP Right Cessation
- 1984-07-05 DE DE8484107861T patent/DE3469534D1/de not_active Expired
- 1984-07-06 GR GR75233A patent/GR82243B/el unknown
- 1984-07-06 IE IE1734/84A patent/IE57698B1/en not_active IP Right Cessation
- 1984-07-06 US US06/628,355 patent/US4636489A/en not_active Expired - Fee Related
- 1984-07-06 JP JP59139198A patent/JPH0670077B2/ja not_active Expired - Lifetime
- 1984-07-06 ES ES534098A patent/ES534098A0/es active Granted
- 1984-07-06 DK DK332684A patent/DK165988C/da active
Also Published As
| Publication number | Publication date |
|---|---|
| DE3469534D1 (en) | 1988-04-07 |
| ATE32728T1 (de) | 1988-03-15 |
| ES8601108A1 (es) | 1985-10-16 |
| DK332684D0 (da) | 1984-07-06 |
| IE841734L (en) | 1985-01-07 |
| CA1230069A (en) | 1987-12-08 |
| ES534098A0 (es) | 1985-10-16 |
| DE3324534A1 (de) | 1985-01-17 |
| DK165988B (da) | 1993-02-22 |
| DK332684A (da) | 1985-01-08 |
| JPH0670077B2 (ja) | 1994-09-07 |
| EP0134479A1 (de) | 1985-03-20 |
| US4636489A (en) | 1987-01-13 |
| IE57698B1 (en) | 1993-03-10 |
| EP0134479B1 (de) | 1988-03-02 |
| DK165988C (da) | 1993-07-26 |
| JPS60105699A (ja) | 1985-06-11 |
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