GR79732B - - Google Patents
Info
- Publication number
- GR79732B GR79732B GR72470A GR830172470A GR79732B GR 79732 B GR79732 B GR 79732B GR 72470 A GR72470 A GR 72470A GR 830172470 A GR830172470 A GR 830172470A GR 79732 B GR79732 B GR 79732B
- Authority
- GR
- Greece
- Prior art keywords
- indolones
- phenyl
- treatment
- aminoalkylidene
- valuable
- Prior art date
Links
- XRKBWYMXJJLQTN-UHFFFAOYSA-N 1-phenyl-3-pyrrolidin-2-ylideneindol-2-one Chemical class O=C1N(C=2C=CC=CC=2)C2=CC=CC=C2C1=C1CCCN1 XRKBWYMXJJLQTN-UHFFFAOYSA-N 0.000 abstract 1
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- 230000036506 anxiety Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 206010015037 epilepsy Diseases 0.000 abstract 1
- 239000003445 gaba agent Substances 0.000 abstract 1
- 239000003176 neuroleptic agent Substances 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 201000000980 schizophrenia Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
- C07C43/225—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/38—Oxygen atoms in positions 2 and 3, e.g. isatin
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Neurosurgery (AREA)
- Public Health (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Anesthesiology (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Dental Preparations (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/420,544 US4476307A (en) | 1982-09-20 | 1982-09-20 | Heteroylidene indolone compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GR79732B true GR79732B (en, 2012) | 1984-10-31 |
Family
ID=23666904
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GR72470A GR79732B (en, 2012) | 1982-09-20 | 1983-09-19 |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US4476307A (en, 2012) |
| EP (1) | EP0104860B1 (en, 2012) |
| JP (1) | JPS5976058A (en, 2012) |
| KR (1) | KR860001270B1 (en, 2012) |
| AT (1) | ATE25972T1 (en, 2012) |
| AU (1) | AU543115B2 (en, 2012) |
| CA (1) | CA1194871A (en, 2012) |
| DD (1) | DD213211A5 (en, 2012) |
| DE (1) | DE3370325D1 (en, 2012) |
| DK (1) | DK157010C (en, 2012) |
| ES (3) | ES525737A0 (en, 2012) |
| FI (1) | FI77446C (en, 2012) |
| GR (1) | GR79732B (en, 2012) |
| HU (1) | HU189747B (en, 2012) |
| IE (1) | IE55923B1 (en, 2012) |
| IL (1) | IL69758A (en, 2012) |
| NO (1) | NO161557C (en, 2012) |
| NZ (1) | NZ205638A (en, 2012) |
| PH (1) | PH18297A (en, 2012) |
| PL (3) | PL141609B1 (en, 2012) |
| PT (1) | PT77360B (en, 2012) |
| SU (1) | SU1272983A3 (en, 2012) |
| YU (4) | YU189283A (en, 2012) |
| ZA (1) | ZA836933B (en, 2012) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4879391A (en) * | 1982-09-20 | 1989-11-07 | Pfizer Inc. | 1-Phenyl-2(1H,3H)-indolone psychotherapeutic agents |
| US4760083A (en) * | 1986-04-10 | 1988-07-26 | E. I. Dupont De Nemours & Company | 3,3-disubstituted indolines |
| HU217072B (hu) * | 1989-01-10 | 1999-11-29 | Pfizer Inc. | 1-Heteroaril-oxindol-3-karboxamid-származékok, azok előállítása, és az azokat tartalmazó gyógyszerkészítmények |
| US5078756A (en) * | 1990-01-12 | 1992-01-07 | Major Thomas O | Apparatus and method for purification and recovery of refrigerant |
| US5158969A (en) * | 1991-08-21 | 1992-10-27 | Neurosearch A/S | Indole derivatives as potassium channel blockers |
| US5760250A (en) * | 1991-11-05 | 1998-06-02 | Zeneca Limited | Process for the preparation of 3-(α-methoxy)methylenebenzofuranones and intermediates therefor |
| DE19949209A1 (de) * | 1999-10-13 | 2001-04-19 | Boehringer Ingelheim Pharma | In 5-Stellung substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel |
| JP2005508336A (ja) * | 2001-09-27 | 2005-03-31 | アラーガン、インコーポレイテッド | キナーゼ阻害物質としての３−（アリールアミノ）メチレン−１，３−ジヒドロ−２ｈ−インドール−２−オン類 |
| US20050101788A1 (en) * | 2002-03-27 | 2005-05-12 | Jacopo Zanon | Method for manufacture of sertindole |
| FR2847811B1 (fr) * | 2002-11-29 | 2005-01-07 | Oreal | Composition filtrante contenant au moins un derive du dibenzoylmethane et au moins un derive de 3-(2-azacycloalkylidene)-1,3-dihydro-indol-2-one;procede de photostabilisation |
| FR2847813A1 (fr) * | 2002-11-29 | 2004-06-04 | Oreal | Compositions cosmetiques photoprotectrices contenant des derives de 3-(2-azacycloalkylidene)-1,3-dihydro-indol-2-one et utilisations |
| MX2007014114A (es) | 2005-05-10 | 2008-03-14 | Intermune Inc | Derivados de piridona para modular el sistema de proteina cinasa activada por estres. |
| JP5627574B2 (ja) | 2008-06-03 | 2014-11-19 | インターミューン， インコーポレイテッド | 炎症性および線維性疾患を治療するための化合物および方法 |
| HRP20141067T1 (hr) | 2008-12-19 | 2015-01-02 | Nippon Soda Co., Ltd. | Derivat 1-heterodiena i sredstvo za kontrolu štetnih organizama |
| CN102596931B (zh) | 2009-11-12 | 2014-07-02 | 日本曹达株式会社 | 1-杂原子二烯衍生物和有害生物防除剂 |
| AR092742A1 (es) | 2012-10-02 | 2015-04-29 | Intermune Inc | Piridinonas antifibroticas |
| HK1215170A1 (zh) | 2012-11-14 | 2016-08-19 | The Johns Hopkins University | 治療精神分裂症的方法和組合物 |
| KR102373700B1 (ko) | 2014-04-02 | 2022-03-11 | 인터뮨, 인크. | 항섬유성 피리디논 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3506683A (en) * | 1963-10-07 | 1970-04-14 | Upjohn Co | 3-(2-pyrrolidinylidene)-3h-indoles |
| GB1237008A (en) * | 1968-12-18 | 1971-06-30 | Pfizer Ltd | Novel indoline derivatives |
| US3723457A (en) * | 1969-09-30 | 1973-03-27 | Eisai Co Ltd | Indoline-2-one derivatives and preparation thereof |
| GB1374414A (en) * | 1972-06-12 | 1974-11-20 | Sterling Drug Inc | 1-acyl-3-amino-alkyl-indoles and their preparation |
| DE2557342A1 (de) * | 1975-12-19 | 1977-06-30 | Hoechst Ag | Basisch substituierte indolderivate und verfahren zu ihrer herstellung |
-
1982
- 1982-09-20 US US06/420,544 patent/US4476307A/en not_active Expired - Fee Related
-
1983
- 1983-09-16 CA CA000436845A patent/CA1194871A/en not_active Expired
- 1983-09-18 IL IL69758A patent/IL69758A/xx unknown
- 1983-09-19 ES ES525737A patent/ES525737A0/es active Granted
- 1983-09-19 KR KR1019830004396A patent/KR860001270B1/ko not_active Expired
- 1983-09-19 HU HU833235A patent/HU189747B/hu unknown
- 1983-09-19 NO NO833367A patent/NO161557C/no unknown
- 1983-09-19 NZ NZ205638A patent/NZ205638A/en unknown
- 1983-09-19 AU AU19252/83A patent/AU543115B2/en not_active Ceased
- 1983-09-19 DD DD83254923A patent/DD213211A5/de unknown
- 1983-09-19 PT PT77360A patent/PT77360B/pt not_active IP Right Cessation
- 1983-09-19 SU SU833646758A patent/SU1272983A3/ru active
- 1983-09-19 DE DE8383305484T patent/DE3370325D1/de not_active Expired
- 1983-09-19 GR GR72470A patent/GR79732B/el unknown
- 1983-09-19 AT AT83305484T patent/ATE25972T1/de not_active IP Right Cessation
- 1983-09-19 ZA ZA836933A patent/ZA836933B/xx unknown
- 1983-09-19 IE IE2193/83A patent/IE55923B1/en not_active IP Right Cessation
- 1983-09-19 FI FI833335A patent/FI77446C/fi not_active IP Right Cessation
- 1983-09-19 DK DK425383A patent/DK157010C/da not_active IP Right Cessation
- 1983-09-19 EP EP83305484A patent/EP0104860B1/en not_active Expired
- 1983-09-20 PL PL1983243826A patent/PL141609B1/pl unknown
- 1983-09-20 PL PL1983250768A patent/PL141370B1/pl unknown
- 1983-09-20 PL PL1983250769A patent/PL141876B1/pl unknown
- 1983-09-20 PH PH29565A patent/PH18297A/en unknown
- 1983-09-20 JP JP58174025A patent/JPS5976058A/ja active Granted
- 1983-09-20 YU YU01892/83A patent/YU189283A/xx unknown
-
1984
- 1984-04-25 ES ES531908A patent/ES531908A0/es active Granted
- 1984-04-25 ES ES531907A patent/ES8505950A1/es not_active Expired
-
1986
- 1986-10-01 YU YU01692/86A patent/YU169286A/xx unknown
- 1986-10-01 YU YU01693/86A patent/YU169386A/xx unknown
- 1986-10-01 YU YU01691/86A patent/YU169186A/xx unknown
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