GR3036401T3 - Process for the preparation of zeaxanthin, intermediates for this process and process for their preparation - Google Patents
Process for the preparation of zeaxanthin, intermediates for this process and process for their preparationInfo
- Publication number
- GR3036401T3 GR3036401T3 GR20010401258T GR20010401258T GR3036401T3 GR 3036401 T3 GR3036401 T3 GR 3036401T3 GR 20010401258 T GR20010401258 T GR 20010401258T GR 20010401258 T GR20010401258 T GR 20010401258T GR 3036401 T3 GR3036401 T3 GR 3036401T3
- Authority
- GR
- Greece
- Prior art keywords
- iii
- trimethyl
- formula
- preparation
- oxa
- Prior art date
Links
- 238000002360 preparation method Methods 0.000 title abstract 4
- JKQXZKUSFCKOGQ-LOFNIBRQSA-N all-trans-Zeaxanthin Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CC(O)CC1(C)C)C=CC=C(/C)C=CC2=C(C)CC(O)CC2(C)C JKQXZKUSFCKOGQ-LOFNIBRQSA-N 0.000 title abstract 2
- 238000000034 method Methods 0.000 title 3
- JKQXZKUSFCKOGQ-JLGXGRJMSA-N (3R,3'R)-beta,beta-carotene-3,3'-diol Chemical compound C([C@H](O)CC=1C)C(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)C[C@@H](O)CC1(C)C JKQXZKUSFCKOGQ-JLGXGRJMSA-N 0.000 title 1
- JKQXZKUSFCKOGQ-LQFQNGICSA-N Z-zeaxanthin Natural products C([C@H](O)CC=1C)C(C)(C)C=1C=CC(C)=CC=CC(C)=CC=CC=C(C)C=CC=C(C)C=CC1=C(C)C[C@@H](O)CC1(C)C JKQXZKUSFCKOGQ-LQFQNGICSA-N 0.000 title 1
- QOPRSMDTRDMBNK-RNUUUQFGSA-N Zeaxanthin Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCC(O)C1(C)C)C=CC=C(/C)C=CC2=C(C)CC(O)CC2(C)C QOPRSMDTRDMBNK-RNUUUQFGSA-N 0.000 title 1
- 239000000543 intermediate Substances 0.000 title 1
- KBPHJBAIARWVSC-XQIHNALSSA-N trans-lutein Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CC(O)CC1(C)C)C=CC=C(/C)C=CC2C(=CC(O)CC2(C)C)C KBPHJBAIARWVSC-XQIHNALSSA-N 0.000 title 1
- 229940043269 zeaxanthin Drugs 0.000 title 1
- 235000010930 zeaxanthin Nutrition 0.000 title 1
- 239000001775 zeaxanthin Substances 0.000 title 1
- 239000000203 mixture Substances 0.000 abstract 3
- CSPVUHYZUZZRGF-COBSHVIPSA-N (4r)-4-hydroxy-2,2,6-trimethylcyclohexan-1-one Chemical compound CC1C[C@@H](O)CC(C)(C)C1=O CSPVUHYZUZZRGF-COBSHVIPSA-N 0.000 abstract 2
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 abstract 2
- IMNFDUFMRHMDMM-UHFFFAOYSA-N N-Heptane Chemical compound CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 abstract 2
- XYFCBTPGUUZFHI-UHFFFAOYSA-N Phosphine Chemical compound P XYFCBTPGUUZFHI-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 239000011541 reaction mixture Substances 0.000 abstract 2
- RIOQSEWOXXDEQQ-UHFFFAOYSA-N triphenylphosphine Chemical compound C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 RIOQSEWOXXDEQQ-UHFFFAOYSA-N 0.000 abstract 2
- NLEIKIZQXWXGSC-SZBHIRRCSA-N (1r,5r)-3,3,5-trimethyl-7-oxabicyclo[2.2.1]heptane-4-carbaldehyde Chemical compound C1[C@@H](C)C2(C=O)C(C)(C)C[C@]1([H])O2 NLEIKIZQXWXGSC-SZBHIRRCSA-N 0.000 abstract 1
- AYODHZHFDRRQEZ-UHFFFAOYSA-N 2,7-dimethylocta-2,4,6-trienedial Chemical compound O=CC(C)=CC=CC=C(C)C=O AYODHZHFDRRQEZ-UHFFFAOYSA-N 0.000 abstract 1
- DVSHXLWNRCEDCW-UHFFFAOYSA-N 2-oxopropylphosphonic acid Chemical compound CC(=O)CP(O)(O)=O DVSHXLWNRCEDCW-UHFFFAOYSA-N 0.000 abstract 1
- KEGYLGREJALYDO-FCRFXOBJSA-N 4-[(1r,5r)-3,3,5-trimethyl-7-oxabicyclo[2.2.1]heptan-4-yl]but-3-en-2-one Chemical compound C1[C@@H](C)C2(C=CC(C)=O)C(C)(C)C[C@]1([H])O2 KEGYLGREJALYDO-FCRFXOBJSA-N 0.000 abstract 1
- 101100030361 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) pph-3 gene Proteins 0.000 abstract 1
- 150000001336 alkenes Chemical class 0.000 abstract 1
- 150000001450 anions Chemical class 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 238000005984 hydrogenation reaction Methods 0.000 abstract 1
- 239000012442 inert solvent Substances 0.000 abstract 1
- NYEFUKPRSIREFK-UHFFFAOYSA-N lithium;dichloromethane Chemical compound [Li+].Cl[CH-]Cl NYEFUKPRSIREFK-UHFFFAOYSA-N 0.000 abstract 1
- JRZJOMJEPLMPRA-UHFFFAOYSA-N olefin Natural products CCCCCCCC=C JRZJOMJEPLMPRA-UHFFFAOYSA-N 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000004714 phosphonium salts Chemical class 0.000 abstract 1
- 229910000073 phosphorus hydride Inorganic materials 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- 238000006886 vinylation reaction Methods 0.000 abstract 1
- 238000010792 warming Methods 0.000 abstract 1
- JKQXZKUSFCKOGQ-QAYBQHTQSA-N zeaxanthin Chemical compound C([C@H](O)CC=1C)C(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)C[C@@H](O)CC1(C)C JKQXZKUSFCKOGQ-QAYBQHTQSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
- C07C403/24—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by six-membered non-aromatic rings, e.g. beta-carotene
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/54—Quaternary phosphonium compounds
- C07F9/5435—Cycloaliphatic phosphonium compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19723480A DE19723480A1 (de) | 1997-06-04 | 1997-06-04 | Verfahren zur Herstellung von Zeaxanthin, Zwischenprodukte für dieses Verfahren und Verfahren zu deren Herstellung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GR3036401T3 true GR3036401T3 (en) | 2001-11-30 |
Family
ID=7831410
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GR20010401258T GR3036401T3 (en) | 1997-06-04 | 2001-08-16 | Process for the preparation of zeaxanthin, intermediates for this process and process for their preparation |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6103940A (el) |
| EP (1) | EP0882709B1 (el) |
| JP (1) | JPH11116552A (el) |
| AT (1) | ATE203518T1 (el) |
| DE (2) | DE19723480A1 (el) |
| DK (1) | DK0882709T3 (el) |
| ES (1) | ES2161000T3 (el) |
| GR (1) | GR3036401T3 (el) |
| PT (1) | PT882709E (el) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3466102B2 (ja) * | 1999-03-12 | 2003-11-10 | 沖電気工業株式会社 | 半導体装置及び半導体装置の製造方法 |
| DE10145223A1 (de) * | 2001-09-13 | 2003-04-03 | Basf Ag | Verfahren zur Herstellung von meso-Zeaxanthin |
| GB0501365D0 (en) * | 2005-01-21 | 2005-03-02 | Promar As | Compositions |
| WO2008003737A1 (de) * | 2006-07-07 | 2008-01-10 | Basf Se | Verfahren zur herstellung von 3,3'-dihydroxyisorenieratin sowie neue zwischenprodukte hierfür |
| WO2008003742A1 (de) * | 2006-07-07 | 2008-01-10 | Basf Se | Verfahren und neue zwischenprodukte zur herstellung von 3,3'-dihydroxyisorenieratin |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2521113A (en) * | 1944-03-21 | 1950-09-05 | Belge Produits Chimiques Sa | Process for the synthesis of vinyl esters of carboxylic acids |
| GB812267A (en) * | 1955-12-29 | 1959-04-22 | Hoffmann La Roche | The manufacture of carotenoids |
| GB1173063A (en) * | 1967-02-14 | 1969-12-03 | Roche Products Ltd | Novel Polyene Compounds and a process for the manufacture and conversion thereof |
| US3988205A (en) * | 1974-08-21 | 1976-10-26 | Hoffmann-La Roche Inc. | Optically active cyclohexane derivatives |
| IT1041904B (it) * | 1974-08-21 | 1980-01-10 | Hoffmann La Roche | Procedimento per la preparazione di derivati del cicloesano otticamente attivi |
| GB1598424A (en) * | 1976-10-14 | 1981-09-23 | Roche Products Ltd | Isomerisation process for 9-cis-beta-ionylidenethyl-triarylphosphonium salts |
| CA1111441A (en) * | 1976-12-20 | 1981-10-27 | Werner Bollag | Polyene compounds |
| JPS548489U (el) * | 1977-06-20 | 1979-01-20 | ||
| DE3363374D1 (en) * | 1982-07-16 | 1986-06-12 | Hoffmann La Roche | Catalytic hydrogenation of acetylenic phosphonium salts |
| EP0120341B1 (de) * | 1983-03-25 | 1989-01-25 | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft | Verfahren zur Herstellung von Pentadienol-Derivaten |
| US4661641A (en) * | 1983-06-09 | 1987-04-28 | Hoffmann-La Roche Inc. | Substituted alkynes useful as intermediates in the synthesis of carotenoids |
| JPS6110019A (ja) * | 1984-06-22 | 1986-01-17 | Mizusawa Ind Chem Ltd | ソーコナイト、ヘミモルファイト、或いはウィレマイト構造の合成結晶性ケイ酸亜鉛鉱物の製法 |
| DK171297B1 (da) * | 1987-03-27 | 1996-08-26 | Hoffmann La Roche | Fremgangsmåde til fremstilling af cyclohexenderivater som mellemprodukter til fremstilling af zeaxanthin samt cyclohexenderivater |
| DE4344148A1 (de) * | 1993-12-23 | 1995-08-24 | Basf Ag | Verfahren zur Herstellung von 9-(Z)-Retinsäure |
-
1997
- 1997-06-04 DE DE19723480A patent/DE19723480A1/de not_active Withdrawn
-
1998
- 1998-05-22 DK DK98109285T patent/DK0882709T3/da active
- 1998-05-22 ES ES98109285T patent/ES2161000T3/es not_active Expired - Lifetime
- 1998-05-22 PT PT98109285T patent/PT882709E/pt unknown
- 1998-05-22 DE DE59801069T patent/DE59801069D1/de not_active Expired - Fee Related
- 1998-05-22 AT AT98109285T patent/ATE203518T1/de not_active IP Right Cessation
- 1998-05-22 EP EP98109285A patent/EP0882709B1/de not_active Expired - Lifetime
- 1998-06-04 US US09/090,230 patent/US6103940A/en not_active Expired - Fee Related
- 1998-06-04 JP JP10155887A patent/JPH11116552A/ja not_active Withdrawn
-
2001
- 2001-08-16 GR GR20010401258T patent/GR3036401T3/el not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP0882709B1 (de) | 2001-07-25 |
| EP0882709A1 (de) | 1998-12-09 |
| ES2161000T3 (es) | 2001-11-16 |
| US6103940A (en) | 2000-08-15 |
| PT882709E (pt) | 2002-01-30 |
| ATE203518T1 (de) | 2001-08-15 |
| DE59801069D1 (de) | 2001-08-30 |
| DE19723480A1 (de) | 1998-12-10 |
| DK0882709T3 (da) | 2001-09-24 |
| JPH11116552A (ja) | 1999-04-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ML | Lapse due to non-payment of fees |