GR3034762T3 - Benzothiophene pharmaceutical compounds - Google Patents

Benzothiophene pharmaceutical compounds

Info

Publication number
GR3034762T3
GR3034762T3 GR20000402451T GR20000402451T GR3034762T3 GR 3034762 T3 GR3034762 T3 GR 3034762T3 GR 20000402451 T GR20000402451 T GR 20000402451T GR 20000402451 T GR20000402451 T GR 20000402451T GR 3034762 T3 GR3034762 T3 GR 3034762T3
Authority
GR
Greece
Prior art keywords
alkyl
rdurule
aryl
compounds
progestin
Prior art date
Application number
GR20000402451T
Other languages
English (en)
Inventor
Henry Uhlman Bryant
Jeffrey Alan Dodge
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of GR3034762T3 publication Critical patent/GR3034762T3/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/56—Radicals substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
GR20000402451T 1995-03-10 2000-11-07 Benzothiophene pharmaceutical compounds GR3034762T3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/402,415 US6395755B1 (en) 1995-03-10 1995-03-10 Benzothiophene pharmaceutical compounds

Publications (1)

Publication Number Publication Date
GR3034762T3 true GR3034762T3 (en) 2001-02-28

Family

ID=23591799

Family Applications (1)

Application Number Title Priority Date Filing Date
GR20000402451T GR3034762T3 (en) 1995-03-10 2000-11-07 Benzothiophene pharmaceutical compounds

Country Status (16)

Country Link
US (1) US6395755B1 (el)
EP (2) EP0731100B1 (el)
JP (1) JPH11501930A (el)
AT (2) ATE247100T1 (el)
AU (1) AU697502B2 (el)
BR (1) BR9607775A (el)
CA (1) CA2214261A1 (el)
DE (2) DE69609748T2 (el)
DK (1) DK0731100T3 (el)
ES (2) ES2205702T3 (el)
GR (1) GR3034762T3 (el)
IL (1) IL117398A (el)
PT (1) PT731100E (el)
SI (1) SI0731100T1 (el)
WO (1) WO1996028155A1 (el)
ZA (1) ZA961883B (el)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6432982B1 (en) * 1996-02-21 2002-08-13 Eli Lilly And Company Benzothiophenes, and formulations and methods using same
EP0801066A1 (en) * 1996-03-12 1997-10-15 Eli Lilly And Company Heterocyclic substituted benzothiophenes and pharmaceutical compositions
CA2214072C (en) * 1996-08-29 2006-11-14 Eli Lilly And Company Benzo [b] thiophene compounds, intermediates, processes, compositions, and methods
CA2214196A1 (en) * 1996-09-26 1998-03-26 Eli Lilly And Company Benzo[b]indeno[2,1-d]thiophene compounds, intermediates, processes, compositions and methods
CA2216592C (en) * 1996-10-24 2006-07-18 Brian Stephen Muehl Benzothiophene compounds, intermediates, compositions, and methods
WO2002094788A1 (en) 2001-05-22 2002-11-28 Eli Lilly And Company 2-substituted 1,2,3,4-tetrahydroquinolines and derivatives thereof, compositions and methods
JP2004531559A (ja) 2001-05-22 2004-10-14 イーライ・リリー・アンド・カンパニー エストロゲン欠乏または内因性エストロゲンに対する異常な生理反応に関連する疾患を抑制するためのテトラヒドロキノリン誘導体
CN1599606A (zh) 2001-07-31 2005-03-23 辉瑞产品公司 包含雌激素激动剂/拮抗剂、雌激素与孕激素组合的药物组合物、试剂盒和方法
DE602005017577D1 (de) * 2004-01-22 2009-12-24 Lilly Co Eli Selektive östrogen-rezeptor-modulatoren
GR1005694B (el) * 2005-06-08 2007-10-22 Αλεξης Μιχαηλ Ιστοειδικα αντιοιστρογονα ειδικα για τον αλφα υποδοχεα των οιστρογονων

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1300575B (de) * 1965-05-21 1969-08-07 Bristol Myers Co Benzo[b]thiophene
US3947470A (en) 1974-06-20 1976-03-30 Smithkline Corporation Substituted benzofurans and benzothiophenes
US4133814A (en) * 1975-10-28 1979-01-09 Eli Lilly And Company 2-Phenyl-3-aroylbenzothiophenes useful as antifertility agents
IT1154888B (it) * 1980-11-12 1987-01-21 Menarini Sas Derivati del benzofurano 2-sostituiti e relativi metodi di preparazione
IL65379A0 (en) * 1981-04-03 1982-05-31 Lilly Co Eli Process for preparing acylated benzothiophenes
AU555658B2 (en) * 1981-04-03 1986-10-02 Eli Lilly And Company Benzothiophene compounds
US4380635A (en) 1981-04-03 1983-04-19 Eli Lilly And Company Synthesis of acylated benzothiophenes
US4418068A (en) * 1981-04-03 1983-11-29 Eli Lilly And Company Antiestrogenic and antiandrugenic benzothiophenes
US4851554A (en) 1987-04-06 1989-07-25 University Of Tennessee Research Corporation Certain 3-substituted 2-alkyl benzofuran derivatives
WO1989002893A1 (en) * 1987-09-30 1989-04-06 The University Of Tennessee Research Corporation Certain 3-substituted 2-alkyl benzothiophene derivatives
US5395842A (en) * 1988-10-31 1995-03-07 Endorecherche Inc. Anti-estrogenic compounds and compositions
FR2665444B1 (fr) * 1990-08-06 1992-11-27 Sanofi Sa Derives d'amino-benzofuranne, benzothiophene ou indole, leur procede de preparation ainsi que les compositions les contenant.
DE4117512A1 (de) * 1991-05-25 1992-11-26 Schering Ag 2-phenylbenzo(b)furane und -thiophene, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate
JP3157882B2 (ja) * 1991-11-15 2001-04-16 帝国臓器製薬株式会社 新規なベンゾチオフエン誘導体
TW366342B (en) 1992-07-28 1999-08-11 Lilly Co Eli The use of 2-phenyl-3-aroylbenzothiophenes in inhibiting bone loss
US5482949A (en) 1993-03-19 1996-01-09 Eli Lilly And Company Sulfonate derivatives of 3-aroylbenzo[b]thiophenes
US6756388B1 (en) * 1993-10-12 2004-06-29 Pfizer Inc. Benzothiophenes and related compounds as estrogen agonists
US5523309A (en) * 1995-03-10 1996-06-04 Eli Lilly And Company Benzofuran pharmaceutical compounds

Also Published As

Publication number Publication date
MX9706737A (es) 1997-11-29
US6395755B1 (en) 2002-05-28
WO1996028155A1 (en) 1996-09-19
IL117398A (en) 2000-11-21
PT731100E (pt) 2001-01-31
EP0731100A1 (en) 1996-09-11
CA2214261A1 (en) 1996-09-19
DK0731100T3 (da) 2000-09-18
ZA961883B (en) 1997-09-08
ATE247100T1 (de) 2003-08-15
EP0953568B1 (en) 2003-08-13
DE69629500D1 (de) 2003-09-18
AU5304896A (en) 1996-10-02
EP0731100B1 (en) 2000-08-16
SI0731100T1 (en) 2001-02-28
ATE195519T1 (de) 2000-09-15
DE69609748D1 (de) 2000-09-21
EP0953568A1 (en) 1999-11-03
ES2148681T3 (es) 2000-10-16
DE69629500T2 (de) 2004-07-01
DE69609748T2 (de) 2001-04-12
BR9607775A (pt) 1998-07-07
IL117398A0 (en) 1996-07-23
JPH11501930A (ja) 1999-02-16
AU697502B2 (en) 1998-10-08
ES2205702T3 (es) 2004-05-01

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Legal Events

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