GR3030330T3 - Process for the preparation of certain substituted biphenyl tetrazoles - Google Patents
Process for the preparation of certain substituted biphenyl tetrazolesInfo
- Publication number
- GR3030330T3 GR3030330T3 GR990401417T GR990401417T GR3030330T3 GR 3030330 T3 GR3030330 T3 GR 3030330T3 GR 990401417 T GR990401417 T GR 990401417T GR 990401417 T GR990401417 T GR 990401417T GR 3030330 T3 GR3030330 T3 GR 3030330T3
- Authority
- GR
- Greece
- Prior art keywords
- preparation
- substituted biphenyl
- certain substituted
- tetrazoles
- biphenyl tetrazoles
- Prior art date
Links
- NWAUPHAHIDQCHS-UHFFFAOYSA-N 1,1'-biphenyl;2h-tetrazole Chemical class C1=NN=NN1.C1=CC=CC=C1C1=CC=CC=C1 NWAUPHAHIDQCHS-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- ZRFGTMYIGSTCSZ-UHFFFAOYSA-N 5-(2-fluorophenyl)-2h-tetrazole Chemical compound FC1=CC=CC=C1C1=NNN=N1 ZRFGTMYIGSTCSZ-UHFFFAOYSA-N 0.000 abstract 1
- 239000007818 Grignard reagent Substances 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 150000004795 grignard reagents Chemical class 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/10—Compounds having one or more C—Si linkages containing nitrogen having a Si-N linkage
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/786,666 US5252753A (en) | 1991-11-01 | 1991-11-01 | Process for the preparation of certain substituted biphenyl tetrazoles and compounds thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GR3030330T3 true GR3030330T3 (en) | 1999-09-30 |
Family
ID=25139265
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GR990401417T GR3030330T3 (en) | 1991-11-01 | 1999-05-27 | Process for the preparation of certain substituted biphenyl tetrazoles |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US5252753A (el) |
| EP (1) | EP0540356B1 (el) |
| JP (1) | JP3145813B2 (el) |
| AT (1) | ATE178058T1 (el) |
| AU (1) | AU651014B2 (el) |
| CA (1) | CA2081847A1 (el) |
| DE (1) | DE69228727T2 (el) |
| DK (1) | DK0540356T3 (el) |
| ES (1) | ES2130161T3 (el) |
| GR (1) | GR3030330T3 (el) |
| SG (1) | SG47012A1 (el) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE914572A1 (en) * | 1991-01-17 | 1992-07-29 | Zeneca Ltd | Chemical process |
| US5616599A (en) * | 1991-02-21 | 1997-04-01 | Sankyo Company, Limited | Angiotensin II antagosist 1-biphenylmethylimidazole compounds and their therapeutic use |
| JP3501484B2 (ja) * | 1992-12-17 | 2004-03-02 | 三共株式会社 | ビフェニル誘導体 |
| DE69521904T2 (de) * | 1994-10-27 | 2002-04-04 | Novartis Ag, Basel | Verfahren zur herstellung tetrazole |
| FR2753705B1 (fr) * | 1996-09-20 | 1999-08-06 | Procede pour la preparation de derives de 4-methyl-biphenyle | |
| JPWO2002083127A1 (ja) * | 2001-04-09 | 2004-09-30 | 宮田 敏男 | 蛋白修飾物生成抑制組成物 |
| EP1571150A1 (en) * | 2004-03-02 | 2005-09-07 | Aventis Pharma Deutschland GmbH | Process for the preparation of tryptase inhibitors |
| KR100953878B1 (ko) * | 2004-09-02 | 2010-04-22 | 테바 파마슈티컬 인더스트리즈 리미티드 | 올메살탄 메독소밀의 정제 |
| US20070054948A1 (en) * | 2004-09-02 | 2007-03-08 | Lilach Hedvati | Purification of olmesartan medoxomil |
| JP4511550B2 (ja) * | 2004-09-02 | 2010-07-28 | テバ ファーマシューティカル インダストリーズ リミティド | オルメサルタンメドキソミルの調製法 |
| EP1749828A1 (en) | 2005-08-04 | 2007-02-07 | Farmaprojects S.L. | Process for preparing an angiotensin II receptor antagonist |
| US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
| CA3089569C (en) | 2007-06-04 | 2023-12-05 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
| US20100120694A1 (en) | 2008-06-04 | 2010-05-13 | Synergy Pharmaceuticals, Inc. | Agonists of Guanylate Cyclase Useful for the Treatment of Gastrointestinal Disorders, Inflammation, Cancer and Other Disorders |
| EP2321341B1 (en) | 2008-07-16 | 2017-02-22 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders |
| US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
| WO2012037298A1 (en) * | 2010-09-17 | 2012-03-22 | Glaxosmithkline Llc | Fatty acid synthase inhibitors |
| EP2970384A1 (en) | 2013-03-15 | 2016-01-20 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase and their uses |
| JP2016514670A (ja) | 2013-03-15 | 2016-05-23 | シナジー ファーマシューティカルズ インコーポレイテッド | 他の薬物と組み合わせたグアニル酸シクラーゼ受容体アゴニスト |
| RS65632B1 (sr) | 2013-06-05 | 2024-07-31 | Bausch Health Ireland Ltd | Ultra-prečišćeni agonisti guanilat-ciklaze c, postupak njihove pripreme i upotrebe |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1334092C (en) * | 1986-07-11 | 1995-01-24 | David John Carini | Angiotensin ii receptor blocking imidazoles |
| US4820843A (en) * | 1987-05-22 | 1989-04-11 | E. I. Du Pont De Nemours And Company | Tetrazole intermediates to antihypertensive compounds |
| EP0412594B1 (en) * | 1989-07-28 | 1996-01-03 | Merck & Co. Inc. | Substituted triazolinones, triazolinethiones, and triazolinimines as angiotensin II antagonists |
| DE122007000050I1 (de) * | 1990-02-19 | 2007-11-08 | Novartis Ag | Acylverbindungen |
| US5039814A (en) * | 1990-05-02 | 1991-08-13 | Merck & Co., Inc. | Ortho-lithiation process for the synthesis of 2-substituted 1-(tetrazol-5-yl)benzenes |
| IE914572A1 (en) * | 1991-01-17 | 1992-07-29 | Zeneca Ltd | Chemical process |
-
1991
- 1991-11-01 US US07/786,666 patent/US5252753A/en not_active Expired - Lifetime
-
1992
- 1992-10-28 AU AU27404/92A patent/AU651014B2/en not_active Ceased
- 1992-10-30 DE DE69228727T patent/DE69228727T2/de not_active Expired - Fee Related
- 1992-10-30 EP EP92309968A patent/EP0540356B1/en not_active Expired - Lifetime
- 1992-10-30 ES ES92309968T patent/ES2130161T3/es not_active Expired - Lifetime
- 1992-10-30 DK DK92309968T patent/DK0540356T3/da active
- 1992-10-30 SG SG1996001913A patent/SG47012A1/en unknown
- 1992-10-30 JP JP31565792A patent/JP3145813B2/ja not_active Expired - Fee Related
- 1992-10-30 AT AT92309968T patent/ATE178058T1/de not_active IP Right Cessation
- 1992-10-30 CA CA002081847A patent/CA2081847A1/en not_active Abandoned
-
1999
- 1999-05-27 GR GR990401417T patent/GR3030330T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US5252753A (en) | 1993-10-12 |
| DE69228727D1 (de) | 1999-04-29 |
| EP0540356B1 (en) | 1999-03-24 |
| JP3145813B2 (ja) | 2001-03-12 |
| SG47012A1 (en) | 1998-03-20 |
| ATE178058T1 (de) | 1999-04-15 |
| AU651014B2 (en) | 1994-07-07 |
| EP0540356A3 (en) | 1993-08-25 |
| DE69228727T2 (de) | 1999-08-19 |
| CA2081847A1 (en) | 1993-05-02 |
| JPH05279350A (ja) | 1993-10-26 |
| ES2130161T3 (es) | 1999-07-01 |
| AU2740492A (en) | 1993-05-06 |
| EP0540356A2 (en) | 1993-05-05 |
| DK0540356T3 (da) | 1999-10-11 |
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