DE69228727D1 - Verfahren zur Herstellung von gewissen Biphenyltetrazolderivaten - Google Patents
Verfahren zur Herstellung von gewissen BiphenyltetrazolderivatenInfo
- Publication number
- DE69228727D1 DE69228727D1 DE69228727T DE69228727T DE69228727D1 DE 69228727 D1 DE69228727 D1 DE 69228727D1 DE 69228727 T DE69228727 T DE 69228727T DE 69228727 T DE69228727 T DE 69228727T DE 69228727 D1 DE69228727 D1 DE 69228727D1
- Authority
- DE
- Germany
- Prior art keywords
- certain
- biphenyltetrazole
- derivatives
- preparation
- disclosed
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 150000001875 compounds Chemical class 0.000 abstract 2
- ZRFGTMYIGSTCSZ-UHFFFAOYSA-N 5-(2-fluorophenyl)-2h-tetrazole Chemical compound FC1=CC=CC=C1C1=NNN=N1 ZRFGTMYIGSTCSZ-UHFFFAOYSA-N 0.000 abstract 1
- 239000007818 Grignard reagent Substances 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 150000004795 grignard reagents Chemical class 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/10—Compounds having one or more C—Si linkages containing nitrogen having a Si-N linkage
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/786,666 US5252753A (en) | 1991-11-01 | 1991-11-01 | Process for the preparation of certain substituted biphenyl tetrazoles and compounds thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69228727D1 true DE69228727D1 (de) | 1999-04-29 |
DE69228727T2 DE69228727T2 (de) | 1999-08-19 |
Family
ID=25139265
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69228727T Expired - Fee Related DE69228727T2 (de) | 1991-11-01 | 1992-10-30 | Verfahren zur Herstellung von gewissen Biphenyltetrazolderivaten |
Country Status (11)
Country | Link |
---|---|
US (1) | US5252753A (de) |
EP (1) | EP0540356B1 (de) |
JP (1) | JP3145813B2 (de) |
AT (1) | ATE178058T1 (de) |
AU (1) | AU651014B2 (de) |
CA (1) | CA2081847A1 (de) |
DE (1) | DE69228727T2 (de) |
DK (1) | DK0540356T3 (de) |
ES (1) | ES2130161T3 (de) |
GR (1) | GR3030330T3 (de) |
SG (1) | SG47012A1 (de) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IE914572A1 (en) * | 1991-01-17 | 1992-07-29 | Zeneca Ltd | Chemical process |
US5616599A (en) * | 1991-02-21 | 1997-04-01 | Sankyo Company, Limited | Angiotensin II antagosist 1-biphenylmethylimidazole compounds and their therapeutic use |
HU219598B (hu) * | 1992-12-17 | 2001-05-28 | Sankyo Co. Ltd. | Bifenilvegyületek imidazol- és piridinszármazékai, eljárás előállításukra és ezeket a vegyületeket tartalmazó gyógyszerkészítmények |
AU3868595A (en) * | 1994-10-27 | 1996-05-23 | Novartis Ag | Process for the preparation of tetrazoles |
FR2753705B1 (fr) * | 1996-09-20 | 1999-08-06 | Procede pour la preparation de derives de 4-methyl-biphenyle | |
WO2002083127A1 (fr) * | 2001-04-09 | 2002-10-24 | Tokai University Educational System | Compositions inhibant la modification proteique |
EP1571150A1 (de) * | 2004-03-02 | 2005-09-07 | Aventis Pharma Deutschland GmbH | Prozess zur Herstellung von Tryptase Hemmstoffen |
US20070054948A1 (en) * | 2004-09-02 | 2007-03-08 | Lilach Hedvati | Purification of olmesartan medoxomil |
CA2575177A1 (en) * | 2004-09-02 | 2006-03-16 | Teva Pharmaceutical Industries Ltd. | Purification of olmesartan medoxomil |
EP1706401A1 (de) * | 2004-09-02 | 2006-10-04 | Teva Pharmaceutical Industries Ltd. | Herstellung von olmesartan-medoxomil |
EP1749828A1 (de) | 2005-08-04 | 2007-02-07 | Farmaprojects S.L. | Verfahren zur Herstellung eines Angiotensin-II-Antagonisten |
US7879802B2 (en) | 2007-06-04 | 2011-02-01 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
US8034782B2 (en) | 2008-07-16 | 2011-10-11 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
JP2011522828A (ja) | 2008-06-04 | 2011-08-04 | シナジー ファーマシューティカルズ インコーポレイテッド | 胃腸障害、炎症、癌、およびその他の障害の治療のために有用なグアニル酸シクラーゼのアゴニスト |
US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
WO2012037298A1 (en) * | 2010-09-17 | 2012-03-22 | Glaxosmithkline Llc | Fatty acid synthase inhibitors |
WO2014151200A2 (en) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Compositions useful for the treatment of gastrointestinal disorders |
US9708367B2 (en) | 2013-03-15 | 2017-07-18 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase and their uses |
AU2014274812B2 (en) | 2013-06-05 | 2018-09-27 | Bausch Health Ireland Limited | Ultra-pure agonists of guanylate cyclase C, method of making and using same |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1334092C (en) * | 1986-07-11 | 1995-01-24 | David John Carini | Angiotensin ii receptor blocking imidazoles |
US4820843A (en) * | 1987-05-22 | 1989-04-11 | E. I. Du Pont De Nemours And Company | Tetrazole intermediates to antihypertensive compounds |
DE69024556T2 (de) * | 1989-07-28 | 1996-10-17 | Merck & Co Inc | Substituierte Triazolinone, Triazolinthione und Triazolinimine als Angiotensin II-Antagonisten |
DE122007000050I1 (de) * | 1990-02-19 | 2007-11-08 | Novartis Ag | Acylverbindungen |
US5039814A (en) * | 1990-05-02 | 1991-08-13 | Merck & Co., Inc. | Ortho-lithiation process for the synthesis of 2-substituted 1-(tetrazol-5-yl)benzenes |
IE914572A1 (en) * | 1991-01-17 | 1992-07-29 | Zeneca Ltd | Chemical process |
-
1991
- 1991-11-01 US US07/786,666 patent/US5252753A/en not_active Expired - Lifetime
-
1992
- 1992-10-28 AU AU27404/92A patent/AU651014B2/en not_active Ceased
- 1992-10-30 ES ES92309968T patent/ES2130161T3/es not_active Expired - Lifetime
- 1992-10-30 SG SG1996001913A patent/SG47012A1/en unknown
- 1992-10-30 AT AT92309968T patent/ATE178058T1/de not_active IP Right Cessation
- 1992-10-30 CA CA002081847A patent/CA2081847A1/en not_active Abandoned
- 1992-10-30 DK DK92309968T patent/DK0540356T3/da active
- 1992-10-30 DE DE69228727T patent/DE69228727T2/de not_active Expired - Fee Related
- 1992-10-30 JP JP31565792A patent/JP3145813B2/ja not_active Expired - Fee Related
- 1992-10-30 EP EP92309968A patent/EP0540356B1/de not_active Expired - Lifetime
-
1999
- 1999-05-27 GR GR990401417T patent/GR3030330T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
DE69228727T2 (de) | 1999-08-19 |
AU651014B2 (en) | 1994-07-07 |
JPH05279350A (ja) | 1993-10-26 |
AU2740492A (en) | 1993-05-06 |
EP0540356A3 (en) | 1993-08-25 |
ES2130161T3 (es) | 1999-07-01 |
JP3145813B2 (ja) | 2001-03-12 |
US5252753A (en) | 1993-10-12 |
GR3030330T3 (en) | 1999-09-30 |
DK0540356T3 (da) | 1999-10-11 |
EP0540356A2 (de) | 1993-05-05 |
EP0540356B1 (de) | 1999-03-24 |
CA2081847A1 (en) | 1993-05-02 |
ATE178058T1 (de) | 1999-04-15 |
SG47012A1 (en) | 1998-03-20 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8328 | Change in the person/name/address of the agent |
Representative=s name: BOEHMERT & BOEHMERT, 28209 BREMEN |
|
8339 | Ceased/non-payment of the annual fee |