GR3022367T3 - Aromatic hydroxyamidine derivatives and their use as leukotriene by receptor anagonists. - Google Patents
Aromatic hydroxyamidine derivatives and their use as leukotriene by receptor anagonists.Info
- Publication number
- GR3022367T3 GR3022367T3 GR970400016T GR970400016T GR3022367T3 GR 3022367 T3 GR3022367 T3 GR 3022367T3 GR 970400016 T GR970400016 T GR 970400016T GR 970400016 T GR970400016 T GR 970400016T GR 3022367 T3 GR3022367 T3 GR 3022367T3
- Authority
- GR
- Greece
- Prior art keywords
- aromatic
- leukotriene
- amino
- compounds
- receptor anagonists
- Prior art date
Links
- 125000003118 aryl group Chemical group 0.000 title 1
- 150000002617 leukotrienes Chemical class 0.000 title 1
- 102000003680 Leukotriene B4 receptors Human genes 0.000 abstract 2
- 108090000093 Leukotriene B4 receptors Proteins 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- 241000124008 Mammalia Species 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 239000005864 Sulphur Substances 0.000 abstract 1
- 230000008485 antagonism Effects 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 239000002464 receptor antagonist Substances 0.000 abstract 1
- 229940044551 receptor antagonist Drugs 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 208000011580 syndromic disease Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
- C07C259/12—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. N-hydroxyamidines
- C07C259/18—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. N-hydroxyamidines having carbon atoms of hydroxamidine groups bound to carbon atoms of six-membered aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Lubricants (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/987,856 US5455274A (en) | 1992-12-09 | 1992-12-09 | Hydroxyamidine derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GR3022367T3 true GR3022367T3 (en) | 1997-04-30 |
Family
ID=25533631
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GR970400016T GR3022367T3 (en) | 1992-12-09 | 1997-01-23 | Aromatic hydroxyamidine derivatives and their use as leukotriene by receptor anagonists. |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US5455274A (enExample) |
| EP (1) | EP0601977B1 (enExample) |
| JP (1) | JPH06263710A (enExample) |
| KR (1) | KR940014313A (enExample) |
| AT (1) | ATE148103T1 (enExample) |
| AU (1) | AU671683B2 (enExample) |
| CA (1) | CA2110838A1 (enExample) |
| DE (1) | DE69307669T2 (enExample) |
| DK (1) | DK0601977T3 (enExample) |
| ES (1) | ES2096265T3 (enExample) |
| FI (1) | FI935452A7 (enExample) |
| GR (1) | GR3022367T3 (enExample) |
| HU (1) | HUT65778A (enExample) |
| IL (1) | IL107842A (enExample) |
| NO (2) | NO180300C (enExample) |
| NZ (1) | NZ250379A (enExample) |
| PH (1) | PH29931A (enExample) |
| TW (2) | TW267999B (enExample) |
| ZA (1) | ZA939193B (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5821267A (en) * | 1993-10-21 | 1998-10-13 | G.D. Searle & Co. | Amidino derivatives useful as nitric oxide synthase inhibitors |
| DE4424713A1 (de) * | 1994-07-13 | 1996-01-18 | Boehringer Ingelheim Kg | Substituierte Benzamidine, ihre Herstellung und Verwendung als Arnzneistoffe |
| JP2770769B2 (ja) * | 1995-02-16 | 1998-07-02 | 日本メクトロン株式会社 | ビスアミドキシム化合物、その製造法およびそれを含有する含フッ素エラストマー組成物 |
| ID24720A (id) * | 1997-12-12 | 2000-08-03 | Novartis Ag | Senyawa amidino tersubstitusi dalam perawatan penyakit gangguan paru-paru kronis |
| WO2000027199A1 (en) * | 1998-11-12 | 2000-05-18 | Eli Lilly And Company | Aminobenzisoxazole compounds and libraries thereof |
| US7262223B2 (en) | 2004-01-23 | 2007-08-28 | Neurochem (International) Limited | Amidine derivatives for treating amyloidosis |
| CA2554696C (en) | 2004-02-13 | 2009-06-30 | Warner-Lambert Company Llc | Androgen receptor modulators |
| WO2005100305A1 (en) | 2004-04-13 | 2005-10-27 | Warner-Lambert Company Llc | Androgen modulators |
| BRPI0509980A (pt) | 2004-04-22 | 2007-10-16 | Warner Lambert Co | moduladores de androgênio |
| US8338648B2 (en) * | 2004-06-12 | 2012-12-25 | Signum Biosciences, Inc. | Topical compositions and methods for epithelial-related conditions |
| CA2572898C (en) * | 2004-07-05 | 2010-04-20 | Dong Wha Pharmaceutical Ind. Co., Ltd. | Composition for the prevention and treatment of allergic inflammatory disease |
| MXPA06015169A (es) | 2004-07-08 | 2007-08-21 | Warner Lambert Co | Moduladores de androgenos. |
| KR20060017929A (ko) | 2004-08-04 | 2006-02-28 | 동화약품공업주식회사 | 티아졸 유도체가 치환된 신규한 벤즈아미딘 유도체, 그의제조방법 및 이를 유효성분으로 하는 약학 조성물 |
| TW200724139A (en) | 2005-05-05 | 2007-07-01 | Warner Lambert Co | Androgen modulators |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5922697B2 (ja) * | 1976-01-13 | 1984-05-28 | エーザイ株式会社 | ビス−（メタ−アミジノフエノキシ）−化合物 |
| NL7908922A (nl) * | 1979-12-12 | 1981-07-16 | Akzo Nv | Carboximidamide derivaten. |
| US4324794A (en) * | 1980-08-26 | 1982-04-13 | Research Triangle Institute | Inhibition of respiratory syncytial virus-induced cell fusion by amidino compounds |
| US4661505A (en) * | 1982-11-03 | 1987-04-28 | Eli Lilly And Company | Leukotriene antagonists |
| CA1243322A (en) * | 1984-01-23 | 1988-10-18 | Joshua Rokach | Antagonists of slow reacting substances of anaphylaxis |
| US4717736A (en) * | 1984-01-23 | 1988-01-05 | Merck Frosst Canada, Inc. | Antagonists of slow reacting substances of anaphylaxis |
| DE3830054A1 (de) * | 1988-09-03 | 1990-03-15 | Boehringer Mannheim Gmbh | Phenylamide - verfahren zu ihrer herstellung sowie diese verbindungen enthaltende arzneimittel |
| US4933347A (en) * | 1988-10-25 | 1990-06-12 | University Of North Carolina At Chapel Hill | Diamidines and bis(imidazolines) for the treatment of and prophylaxis against pneumocystis carinii pneumonia |
| US4963589A (en) * | 1988-10-25 | 1990-10-16 | The University Of North Carolina At Chapel Hill | Methods for treating Giardia lamblia |
| US5162361A (en) * | 1990-04-10 | 1992-11-10 | The United States Of America As Represented By The Secretary, Department Of Health And Human Services | Method of treating diseases associated with elevated levels of interleukin 1 |
| US5124350A (en) * | 1990-06-28 | 1992-06-23 | G. D. Searle & Co. | Leukotriene b4 antagonists |
| CA2129526A1 (en) * | 1992-02-05 | 1993-08-06 | Franz Birke | Novel amidine derivatives, their preparation and their use as medicaments with ltb4 antagonistic effect |
-
1992
- 1992-12-09 US US07/987,856 patent/US5455274A/en not_active Expired - Fee Related
-
1993
- 1993-11-24 PH PH47320A patent/PH29931A/en unknown
- 1993-11-26 JP JP5296853A patent/JPH06263710A/ja active Pending
- 1993-11-30 DK DK93810841.2T patent/DK0601977T3/da active
- 1993-11-30 AT AT93810841T patent/ATE148103T1/de not_active IP Right Cessation
- 1993-11-30 EP EP93810841A patent/EP0601977B1/en not_active Expired - Lifetime
- 1993-11-30 DE DE69307669T patent/DE69307669T2/de not_active Expired - Fee Related
- 1993-11-30 ES ES93810841T patent/ES2096265T3/es not_active Expired - Lifetime
- 1993-12-02 IL IL10784293A patent/IL107842A/en not_active IP Right Cessation
- 1993-12-03 FI FI935452A patent/FI935452A7/fi unknown
- 1993-12-03 AU AU52180/93A patent/AU671683B2/en not_active Ceased
- 1993-12-07 NZ NZ250379A patent/NZ250379A/en unknown
- 1993-12-07 CA CA002110838A patent/CA2110838A1/en not_active Abandoned
- 1993-12-08 KR KR1019930026826A patent/KR940014313A/ko not_active Withdrawn
- 1993-12-08 ZA ZA939193A patent/ZA939193B/xx unknown
- 1993-12-08 HU HU9303501A patent/HUT65778A/hu unknown
- 1993-12-08 NO NO934483A patent/NO180300C/no unknown
- 1993-12-08 NO NO934483D patent/NO934483D0/no unknown
- 1993-12-22 TW TW082110864A patent/TW267999B/zh active
-
1994
- 1994-01-19 TW TW083100416A patent/TW294651B/zh not_active IP Right Cessation
-
1997
- 1997-01-23 GR GR970400016T patent/GR3022367T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| TW267999B (enExample) | 1996-01-11 |
| FI935452A7 (fi) | 1994-06-10 |
| HUT65778A (en) | 1994-07-28 |
| EP0601977A1 (en) | 1994-06-15 |
| DE69307669D1 (de) | 1997-03-06 |
| NO180300C (no) | 1997-03-26 |
| IL107842A (en) | 1998-08-16 |
| PH29931A (en) | 1996-09-16 |
| TW294651B (enExample) | 1997-01-01 |
| US5455274A (en) | 1995-10-03 |
| DK0601977T3 (da) | 1997-02-10 |
| CA2110838A1 (en) | 1994-06-10 |
| JPH06263710A (ja) | 1994-09-20 |
| HU9303501D0 (en) | 1994-04-28 |
| AU5218093A (en) | 1994-06-23 |
| DE69307669T2 (de) | 1997-11-13 |
| EP0601977B1 (en) | 1997-01-22 |
| ATE148103T1 (de) | 1997-02-15 |
| ES2096265T3 (es) | 1997-03-01 |
| IL107842A0 (en) | 1994-04-12 |
| KR940014313A (ko) | 1994-07-18 |
| NZ250379A (en) | 1995-12-21 |
| NO934483D0 (no) | 1993-12-08 |
| ZA939193B (en) | 1994-06-09 |
| FI935452A0 (fi) | 1993-12-03 |
| NO934483L (no) | 1994-06-10 |
| NO180300B (no) | 1996-12-16 |
| AU671683B2 (en) | 1996-09-05 |
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