GR3018206T3 - Use of macrocyclic nitrogen containing compounds for the treatment of retroviral infections. - Google Patents

Use of macrocyclic nitrogen containing compounds for the treatment of retroviral infections.

Info

Publication number
GR3018206T3
GR3018206T3 GR950403260T GR950403260T GR3018206T3 GR 3018206 T3 GR3018206 T3 GR 3018206T3 GR 950403260 T GR950403260 T GR 950403260T GR 950403260 T GR950403260 T GR 950403260T GR 3018206 T3 GR3018206 T3 GR 3018206T3
Authority
GR
Greece
Prior art keywords
treatment
retroviral infections
containing compounds
nitrogen containing
macrocyclic nitrogen
Prior art date
Application number
GR950403260T
Other languages
English (en)
Inventor
Barry Anthony Murrer
David Aaron Schwartz
Original Assignee
Johnson Matthey Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Johnson Matthey Plc filed Critical Johnson Matthey Plc
Publication of GR3018206T3 publication Critical patent/GR3018206T3/el

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
GR950403260T 1989-12-21 1995-11-23 Use of macrocyclic nitrogen containing compounds for the treatment of retroviral infections. GR3018206T3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/454,418 US5021409A (en) 1989-12-21 1989-12-21 Antiviral cyclic polyamines

Publications (1)

Publication Number Publication Date
GR3018206T3 true GR3018206T3 (en) 1996-02-29

Family

ID=23804523

Family Applications (1)

Application Number Title Priority Date Filing Date
GR950403260T GR3018206T3 (en) 1989-12-21 1995-11-23 Use of macrocyclic nitrogen containing compounds for the treatment of retroviral infections.

Country Status (17)

Country Link
US (1) US5021409A (el)
EP (1) EP0434385B1 (el)
JP (1) JP3133345B2 (el)
KR (1) KR0180019B1 (el)
AT (1) ATE130514T1 (el)
AU (1) AU639514B2 (el)
CA (1) CA2032261C (el)
DE (1) DE69023748T2 (el)
DK (1) DK0434385T3 (el)
ES (1) ES2079453T3 (el)
GR (1) GR3018206T3 (el)
HU (2) HUT67031A (el)
IE (1) IE71640B1 (el)
IL (1) IL96666A (el)
NZ (1) NZ236463A (el)
PT (1) PT96289B (el)
ZA (1) ZA9010184B (el)

Families Citing this family (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9105489D0 (en) * 1991-03-15 1991-05-01 Johnson Matthey Plc Improvements in chemical compounds
GB9126677D0 (en) 1991-12-16 1992-02-12 Johnson Matthey Plc Improvements in chemical compounds
GB9400411D0 (en) * 1994-01-11 1994-03-09 Johnson Matthey Plc Improvements in chemical compounds
KR100447303B1 (ko) * 1994-01-11 2005-08-23 아노메드 인코포레이티드 고리형폴리아민
US5663161A (en) * 1995-02-17 1997-09-02 The Research Foundation Of State University Of New York Anti-viral triaza compounds
US5612478A (en) * 1995-03-30 1997-03-18 Johnson Matthey Plc Process for preparing 1,1'-[1,4-phenylenebis-(methylene)]-bis-1,4,8,11-tetraazacyclotetradecane
US5606053A (en) * 1995-05-02 1997-02-25 Johnson Matthey Plc Process for preparing 1,1'-[1,4-phenylenebis-(methylene)]-bis-1,4,8,11-tetraazacyclotetradecane
US6506770B1 (en) 1996-06-06 2003-01-14 Anormed, Inc. Antiviral compounds
GB9511357D0 (en) * 1995-06-06 1995-08-02 Johnson Matthey Plc Improved antiviral compounds
CA2224003C (en) * 1995-06-07 2010-04-13 Progenics Pharmaceuticals, Inc. Fluorescence resonance energy transfer screening assay for the identification of hiv-1 envelope glycoprotein-medicated cell
EP0841951A2 (en) * 1995-06-26 1998-05-20 Concat Ltd. Compounds with chelation affinity and selectivity for first transition series elements, and their use in medical therapy and diagnosis
US5608061A (en) * 1995-08-02 1997-03-04 Johnson Matthey Plc Process for preparing 1,4,8,11-tetraazacyclotetradecane
US7118859B2 (en) 1996-01-17 2006-10-10 Progenics Pharmaceuticals, Inc. Methods for inhibiting HIV-1 infection
US7858298B1 (en) 1996-04-01 2010-12-28 Progenics Pharmaceuticals Inc. Methods of inhibiting human immunodeficiency virus type 1 (HIV-1) infection through the administration of CCR5 chemokine receptor antagonists
US6344545B1 (en) 1996-06-14 2002-02-05 Progenics Pharmaceuticals, Inc. Method for preventing HIV-1 infection of CD4+ cells
US20040086528A1 (en) * 1996-06-14 2004-05-06 Progenics Pharmaceuticals, Inc. Uses of a chemokine receptor for inhibiting HIV-1 infection
AU5241099A (en) * 1998-07-31 2000-02-21 Trustees Of Columbia University In The City Of New York, The Use of inhibitors of the activation of cxcr4 receptor by sdf-1 in treating rheumatoid arthritis
US20080015348A1 (en) * 1998-12-16 2008-01-17 Progenics Pharmaceuticals, Inc. Nucleic acids encoding polypeptides of anti-CCR5 antibodies
US20040228869A1 (en) * 1998-12-16 2004-11-18 Progenics Pharmaceuticals, Inc. Synergistic inhibition of HIV-1 fusion and attachment, compositions and antibodies thereto
US6365583B1 (en) 1999-02-02 2002-04-02 Anormed, Inc. Methods to enhance white blood cell count
ES2265923T3 (es) 1999-03-24 2007-03-01 Anormed Inc. Compuestos heterociclicos que se unen a receptores de quimiocinas.
US6750348B1 (en) 1999-03-24 2004-06-15 Anormed, Inc. Chemokine receptor binding heterocyclic compounds
EP1173223A2 (en) * 1999-04-30 2002-01-23 Slil Biomedical Corporation Conjugates as therapies for cancers and prostate diseases
US6482943B1 (en) * 1999-04-30 2002-11-19 Slil Biomedical Corporation Quinones as disease therapies
US6794545B1 (en) * 1999-04-30 2004-09-21 Slil Biomedical Corporation Conformationally restricted polyamine analogs as disease therapies
US6649587B1 (en) 1999-04-30 2003-11-18 Slil Biomedical Corporation Polyamine analog conjugates and quinone conjugates as therapies for cancers and prostate diseases
ATE428706T1 (de) * 1999-12-17 2009-05-15 Genzyme Corp Chemokinrezeptor-bindende heterocyclische verbindungen
US8271316B2 (en) * 1999-12-17 2012-09-18 Buzzmetrics Ltd Consumer to business data capturing system
US20030072715A1 (en) * 2000-08-02 2003-04-17 Benjamin Frydman Cyclic polyamine compounds for cancer therapy
AU9156901A (en) * 2000-09-15 2002-03-26 Anormed Inc Chemokine receptor binding heterocyclic compounds
US7138119B2 (en) * 2000-09-15 2006-11-21 Progenics Pharmaceuticals, Inc. Compositions and methods for inhibition of HIV-1 infection
EP1752455B1 (en) * 2000-09-15 2010-11-10 Anormed Inc. Chemokine receptor binding heterocyclic compounds
KR100808385B1 (ko) 2000-09-29 2008-03-07 아노르메드 인코포레이티드 N-1 보호된 n개 환 질소 함유 사이클릭 폴리아민 및 이의 생성물의 제조방법
AU2001297817A1 (en) * 2000-11-08 2002-11-25 Eli Lilly And Company Antiviral therapies using polyamine or polyamine analog-amino acid conjugates
US7060273B2 (en) * 2001-04-06 2006-06-13 Progenics Pharmaceuticals, Inc. Methods for inhibiting HIV-1 infection
US7169750B2 (en) * 2001-07-31 2007-01-30 Anormed, Inc. Methods to mobilize progenitor/stem cells
DK1411918T3 (da) 2001-07-31 2012-04-23 Genzyme Global S A R L Fremgangsmåder til at mobilisere progenitor/stamceller
WO2003050072A1 (en) * 2001-12-07 2003-06-19 Slil Biomedical Corporation Cycloalkyl substituted polyamines for cancer therapy and methods of synthesis therefor
US7354932B2 (en) 2001-12-21 2008-04-08 Anormed, Inc. Chemokine receptor binding heterocyclic compounds with enhanced efficacy
MXPA04006136A (es) 2001-12-21 2004-11-01 Anormed Inc Compuestos heterociclicos que se unen a receptor de quimiocina con eficacia incrementada.
US7122185B2 (en) * 2002-02-22 2006-10-17 Progenics Pharmaceuticals, Inc. Anti-CCR5 antibody
US7291631B2 (en) * 2003-04-11 2007-11-06 Genzyme Corporation CXCR4 chemokine receptor binding compounds
IN266744B (el) * 2003-04-22 2015-05-29 Genzyme Corp
US7501518B2 (en) * 2003-04-22 2009-03-10 Genzyme Corporation Methods of making 2,6-diaryl piperidine derivatives
US7498346B2 (en) * 2003-12-11 2009-03-03 Genzyme Corporation Chemokine receptor binding compounds
WO2005059107A2 (en) * 2003-12-11 2005-06-30 Anormed Inc. Chemokine receptor binding compounds
EP1796716A4 (en) * 2004-08-13 2010-09-08 Anormed Inc COMBINATIONS OF CHEMOKINES FOR MOBILIZING PROGENITOR / STEM CELLS
CA2612325A1 (en) * 2005-06-15 2006-12-28 Anormed Inc. Chemokine receptor binding compounds
MX2008002214A (es) * 2005-08-16 2008-11-27 Genzyme Corp Compuestos de unión del receptor de quimiocina.
AU2006280945A1 (en) 2005-08-19 2007-02-22 Genzyme Corporation Methods to enhance chemotherapy
CN101389329A (zh) * 2006-02-24 2009-03-18 健赞股份有限公司 增加血流和/或促进组织再生的方法
AR063470A1 (es) * 2006-08-02 2009-01-28 Genzyme Corp Terapia combinada
WO2008019371A1 (en) * 2006-08-07 2008-02-14 Genzyme Corporation Combination therapy
CN103596935A (zh) 2011-05-16 2014-02-19 建新公司 Cxcr4拮抗剂的用途
CA3026154A1 (en) 2015-06-03 2016-12-08 The University Of Queensland Mobilizing agents and uses therefor
EP3389634B1 (en) 2015-12-14 2021-10-06 X4 Pharmaceuticals, Inc. Methods for treating cancer
US11357742B2 (en) 2015-12-14 2022-06-14 X4 Pharmaceuticals, Inc. Methods for treating cancer
EP3389720A1 (en) 2015-12-18 2018-10-24 The General Hospital Corporation Polyacetal polymers, conjugates, particles and uses thereof
CN108883091A (zh) 2015-12-22 2018-11-23 X4 制药有限公司 用于治疗免疫缺陷病的方法
CA3019394A1 (en) 2016-04-08 2017-10-12 X4 Pharmaceuticals, Inc. Methods for treating cancer
JP6994767B2 (ja) 2016-06-21 2022-01-14 エックス4 ファーマシューティカルズ, インコーポレイテッド Cxcr4阻害剤およびその使用
EP3808748A1 (en) 2016-06-21 2021-04-21 X4 Pharmaceuticals, Inc. Substituted piperidines as cxcr4-inhibitors
CA3027495A1 (en) 2016-06-21 2017-12-28 X4 Pharmaceuticals, Inc. Cxcr4 inhibitors and uses thereof
WO2018106738A1 (en) 2016-12-05 2018-06-14 Massachusetts Institute Of Technology Brush-arm star polymers, conjugates and particles, and uses thereof
CA3079405A1 (en) 2017-10-31 2019-05-09 Magenta Therapeutics Inc. Compositions and methods for the expansion of hematopoietic stem and progenitor cells
JP2021503008A (ja) 2017-10-31 2021-02-04 マジェンタ セラピューティクス インコーポレイテッドMagenta Therapeutics, Inc. 造血幹細胞および前駆細胞移植療法のための組成物および方法
EP3720494A2 (en) 2017-12-06 2020-10-14 Magenta Therapeutics, Inc. Dosing regimens for the mobilization of hematopoietic stem and progenitor cells
US11260079B2 (en) 2017-12-06 2022-03-01 Magenta Therapeutics, Inc. Dosing regimens for the mobilization of hematopoietic stem and progenitor cells
CA3087527A1 (en) 2018-01-03 2019-07-11 Magenta Therapeutics, Inc. Compositions and methods for the expansion of hematopoietic stem and progenitor cells and treatment of inherited metabolic disorders
US10548889B1 (en) 2018-08-31 2020-02-04 X4 Pharmaceuticals, Inc. Compositions of CXCR4 inhibitors and methods of preparation and use
WO2020112195A1 (en) 2018-11-30 2020-06-04 Yale University Compositions, technologies and methods of using plerixafor to enhance gene editing
US20220401481A1 (en) 2019-11-01 2022-12-22 Magenta Therapeutics, Inc. Dosing regimens for the mobilization of hematopoietic stem and progenitor cells
CN115997009A (zh) 2020-04-27 2023-04-21 美真达治疗公司 用于在体内转导造血干细胞和祖细胞的方法和组合物
EP4308694A1 (en) 2021-03-16 2024-01-24 Magenta Therapeutics, Inc. Dosing regimens for hematopoietic stem cell mobilization for stem cell transplants in multiple myeloma patients

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4156683A (en) * 1973-03-26 1979-05-29 Schering Corporation Complexes of macrocyclic compounds
FR2614020B1 (fr) * 1987-04-14 1989-07-28 Guerbet Sa Nouveaux ligands cycliques azotes, complexes metalliques formes par ces ligands, compositions de diagnostic contenant ces complexes et procede de preparation des ligands.
DE3713842A1 (de) * 1987-04-22 1988-11-17 Schering Ag Substituierte cyclische komplexbildner, komplexe und komplexsalze, verfahren zu deren herstellung und diese enthaltende pharmazeutische mittel
DE4035760A1 (de) * 1990-11-08 1992-05-14 Schering Ag Mono-n-substituierte 1,4,7,10-tetraazacyclododecan-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel

Also Published As

Publication number Publication date
EP0434385B1 (en) 1995-11-22
PT96289B (pt) 1998-06-30
AU6809090A (en) 1991-06-27
IL96666A0 (en) 1991-09-16
CA2032261C (en) 2002-04-23
ES2079453T3 (es) 1996-01-16
ATE130514T1 (de) 1995-12-15
HUT67031A (en) 1995-01-30
US5021409A (en) 1991-06-04
HU908367D0 (en) 1991-07-29
EP0434385A3 (en) 1992-03-04
JP3133345B2 (ja) 2001-02-05
IE904619A1 (en) 1991-07-17
JPH06219945A (ja) 1994-08-09
IE71640B1 (en) 1997-02-26
KR910011267A (ko) 1991-08-07
AU639514B2 (en) 1993-07-29
EP0434385A2 (en) 1991-06-26
DE69023748T2 (de) 1996-05-02
ZA9010184B (en) 1991-11-27
KR0180019B1 (ko) 1999-03-20
PT96289A (pt) 1991-10-15
NZ236463A (en) 1992-04-28
CA2032261A1 (en) 1991-06-22
DK0434385T3 (da) 1995-12-18
DE69023748D1 (de) 1996-01-04
IL96666A (en) 1996-01-31
HU210534A9 (en) 1995-04-28

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