GR3018206T3 - Use of macrocyclic nitrogen containing compounds for the treatment of retroviral infections. - Google Patents
Use of macrocyclic nitrogen containing compounds for the treatment of retroviral infections.Info
- Publication number
- GR3018206T3 GR3018206T3 GR950403260T GR950403260T GR3018206T3 GR 3018206 T3 GR3018206 T3 GR 3018206T3 GR 950403260 T GR950403260 T GR 950403260T GR 950403260 T GR950403260 T GR 950403260T GR 3018206 T3 GR3018206 T3 GR 3018206T3
- Authority
- GR
- Greece
- Prior art keywords
- treatment
- retroviral infections
- containing compounds
- nitrogen containing
- macrocyclic nitrogen
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- AIDS & HIV (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicinal Preparation (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/454,418 US5021409A (en) | 1989-12-21 | 1989-12-21 | Antiviral cyclic polyamines |
Publications (1)
Publication Number | Publication Date |
---|---|
GR3018206T3 true GR3018206T3 (en) | 1996-02-29 |
Family
ID=23804523
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GR950403260T GR3018206T3 (en) | 1989-12-21 | 1995-11-23 | Use of macrocyclic nitrogen containing compounds for the treatment of retroviral infections. |
Country Status (17)
Country | Link |
---|---|
US (1) | US5021409A (el) |
EP (1) | EP0434385B1 (el) |
JP (1) | JP3133345B2 (el) |
KR (1) | KR0180019B1 (el) |
AT (1) | ATE130514T1 (el) |
AU (1) | AU639514B2 (el) |
CA (1) | CA2032261C (el) |
DE (1) | DE69023748T2 (el) |
DK (1) | DK0434385T3 (el) |
ES (1) | ES2079453T3 (el) |
GR (1) | GR3018206T3 (el) |
HU (2) | HUT67031A (el) |
IE (1) | IE71640B1 (el) |
IL (1) | IL96666A (el) |
NZ (1) | NZ236463A (el) |
PT (1) | PT96289B (el) |
ZA (1) | ZA9010184B (el) |
Families Citing this family (74)
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GB9105489D0 (en) * | 1991-03-15 | 1991-05-01 | Johnson Matthey Plc | Improvements in chemical compounds |
GB9126677D0 (en) | 1991-12-16 | 1992-02-12 | Johnson Matthey Plc | Improvements in chemical compounds |
GB9400411D0 (en) * | 1994-01-11 | 1994-03-09 | Johnson Matthey Plc | Improvements in chemical compounds |
KR100447303B1 (ko) * | 1994-01-11 | 2005-08-23 | 아노메드 인코포레이티드 | 고리형폴리아민 |
US5663161A (en) * | 1995-02-17 | 1997-09-02 | The Research Foundation Of State University Of New York | Anti-viral triaza compounds |
US5612478A (en) * | 1995-03-30 | 1997-03-18 | Johnson Matthey Plc | Process for preparing 1,1'-[1,4-phenylenebis-(methylene)]-bis-1,4,8,11-tetraazacyclotetradecane |
US5606053A (en) * | 1995-05-02 | 1997-02-25 | Johnson Matthey Plc | Process for preparing 1,1'-[1,4-phenylenebis-(methylene)]-bis-1,4,8,11-tetraazacyclotetradecane |
US6506770B1 (en) | 1996-06-06 | 2003-01-14 | Anormed, Inc. | Antiviral compounds |
GB9511357D0 (en) * | 1995-06-06 | 1995-08-02 | Johnson Matthey Plc | Improved antiviral compounds |
CA2224003C (en) * | 1995-06-07 | 2010-04-13 | Progenics Pharmaceuticals, Inc. | Fluorescence resonance energy transfer screening assay for the identification of hiv-1 envelope glycoprotein-medicated cell |
EP0841951A2 (en) * | 1995-06-26 | 1998-05-20 | Concat Ltd. | Compounds with chelation affinity and selectivity for first transition series elements, and their use in medical therapy and diagnosis |
US5608061A (en) * | 1995-08-02 | 1997-03-04 | Johnson Matthey Plc | Process for preparing 1,4,8,11-tetraazacyclotetradecane |
US7118859B2 (en) | 1996-01-17 | 2006-10-10 | Progenics Pharmaceuticals, Inc. | Methods for inhibiting HIV-1 infection |
US7858298B1 (en) | 1996-04-01 | 2010-12-28 | Progenics Pharmaceuticals Inc. | Methods of inhibiting human immunodeficiency virus type 1 (HIV-1) infection through the administration of CCR5 chemokine receptor antagonists |
US6344545B1 (en) | 1996-06-14 | 2002-02-05 | Progenics Pharmaceuticals, Inc. | Method for preventing HIV-1 infection of CD4+ cells |
US20040086528A1 (en) * | 1996-06-14 | 2004-05-06 | Progenics Pharmaceuticals, Inc. | Uses of a chemokine receptor for inhibiting HIV-1 infection |
AU5241099A (en) * | 1998-07-31 | 2000-02-21 | Trustees Of Columbia University In The City Of New York, The | Use of inhibitors of the activation of cxcr4 receptor by sdf-1 in treating rheumatoid arthritis |
US20080015348A1 (en) * | 1998-12-16 | 2008-01-17 | Progenics Pharmaceuticals, Inc. | Nucleic acids encoding polypeptides of anti-CCR5 antibodies |
US20040228869A1 (en) * | 1998-12-16 | 2004-11-18 | Progenics Pharmaceuticals, Inc. | Synergistic inhibition of HIV-1 fusion and attachment, compositions and antibodies thereto |
US6365583B1 (en) | 1999-02-02 | 2002-04-02 | Anormed, Inc. | Methods to enhance white blood cell count |
ES2265923T3 (es) | 1999-03-24 | 2007-03-01 | Anormed Inc. | Compuestos heterociclicos que se unen a receptores de quimiocinas. |
US6750348B1 (en) | 1999-03-24 | 2004-06-15 | Anormed, Inc. | Chemokine receptor binding heterocyclic compounds |
EP1173223A2 (en) * | 1999-04-30 | 2002-01-23 | Slil Biomedical Corporation | Conjugates as therapies for cancers and prostate diseases |
US6482943B1 (en) * | 1999-04-30 | 2002-11-19 | Slil Biomedical Corporation | Quinones as disease therapies |
US6794545B1 (en) * | 1999-04-30 | 2004-09-21 | Slil Biomedical Corporation | Conformationally restricted polyamine analogs as disease therapies |
US6649587B1 (en) | 1999-04-30 | 2003-11-18 | Slil Biomedical Corporation | Polyamine analog conjugates and quinone conjugates as therapies for cancers and prostate diseases |
ATE428706T1 (de) * | 1999-12-17 | 2009-05-15 | Genzyme Corp | Chemokinrezeptor-bindende heterocyclische verbindungen |
US8271316B2 (en) * | 1999-12-17 | 2012-09-18 | Buzzmetrics Ltd | Consumer to business data capturing system |
US20030072715A1 (en) * | 2000-08-02 | 2003-04-17 | Benjamin Frydman | Cyclic polyamine compounds for cancer therapy |
AU9156901A (en) * | 2000-09-15 | 2002-03-26 | Anormed Inc | Chemokine receptor binding heterocyclic compounds |
US7138119B2 (en) * | 2000-09-15 | 2006-11-21 | Progenics Pharmaceuticals, Inc. | Compositions and methods for inhibition of HIV-1 infection |
EP1752455B1 (en) * | 2000-09-15 | 2010-11-10 | Anormed Inc. | Chemokine receptor binding heterocyclic compounds |
KR100808385B1 (ko) | 2000-09-29 | 2008-03-07 | 아노르메드 인코포레이티드 | N-1 보호된 n개 환 질소 함유 사이클릭 폴리아민 및 이의 생성물의 제조방법 |
AU2001297817A1 (en) * | 2000-11-08 | 2002-11-25 | Eli Lilly And Company | Antiviral therapies using polyamine or polyamine analog-amino acid conjugates |
US7060273B2 (en) * | 2001-04-06 | 2006-06-13 | Progenics Pharmaceuticals, Inc. | Methods for inhibiting HIV-1 infection |
US7169750B2 (en) * | 2001-07-31 | 2007-01-30 | Anormed, Inc. | Methods to mobilize progenitor/stem cells |
DK1411918T3 (da) | 2001-07-31 | 2012-04-23 | Genzyme Global S A R L | Fremgangsmåder til at mobilisere progenitor/stamceller |
WO2003050072A1 (en) * | 2001-12-07 | 2003-06-19 | Slil Biomedical Corporation | Cycloalkyl substituted polyamines for cancer therapy and methods of synthesis therefor |
US7354932B2 (en) | 2001-12-21 | 2008-04-08 | Anormed, Inc. | Chemokine receptor binding heterocyclic compounds with enhanced efficacy |
MXPA04006136A (es) | 2001-12-21 | 2004-11-01 | Anormed Inc | Compuestos heterociclicos que se unen a receptor de quimiocina con eficacia incrementada. |
US7122185B2 (en) * | 2002-02-22 | 2006-10-17 | Progenics Pharmaceuticals, Inc. | Anti-CCR5 antibody |
US7291631B2 (en) * | 2003-04-11 | 2007-11-06 | Genzyme Corporation | CXCR4 chemokine receptor binding compounds |
IN266744B (el) * | 2003-04-22 | 2015-05-29 | Genzyme Corp | |
US7501518B2 (en) * | 2003-04-22 | 2009-03-10 | Genzyme Corporation | Methods of making 2,6-diaryl piperidine derivatives |
US7498346B2 (en) * | 2003-12-11 | 2009-03-03 | Genzyme Corporation | Chemokine receptor binding compounds |
WO2005059107A2 (en) * | 2003-12-11 | 2005-06-30 | Anormed Inc. | Chemokine receptor binding compounds |
EP1796716A4 (en) * | 2004-08-13 | 2010-09-08 | Anormed Inc | COMBINATIONS OF CHEMOKINES FOR MOBILIZING PROGENITOR / STEM CELLS |
CA2612325A1 (en) * | 2005-06-15 | 2006-12-28 | Anormed Inc. | Chemokine receptor binding compounds |
MX2008002214A (es) * | 2005-08-16 | 2008-11-27 | Genzyme Corp | Compuestos de unión del receptor de quimiocina. |
AU2006280945A1 (en) | 2005-08-19 | 2007-02-22 | Genzyme Corporation | Methods to enhance chemotherapy |
CN101389329A (zh) * | 2006-02-24 | 2009-03-18 | 健赞股份有限公司 | 增加血流和/或促进组织再生的方法 |
AR063470A1 (es) * | 2006-08-02 | 2009-01-28 | Genzyme Corp | Terapia combinada |
WO2008019371A1 (en) * | 2006-08-07 | 2008-02-14 | Genzyme Corporation | Combination therapy |
CN103596935A (zh) | 2011-05-16 | 2014-02-19 | 建新公司 | Cxcr4拮抗剂的用途 |
CA3026154A1 (en) | 2015-06-03 | 2016-12-08 | The University Of Queensland | Mobilizing agents and uses therefor |
EP3389634B1 (en) | 2015-12-14 | 2021-10-06 | X4 Pharmaceuticals, Inc. | Methods for treating cancer |
US11357742B2 (en) | 2015-12-14 | 2022-06-14 | X4 Pharmaceuticals, Inc. | Methods for treating cancer |
EP3389720A1 (en) | 2015-12-18 | 2018-10-24 | The General Hospital Corporation | Polyacetal polymers, conjugates, particles and uses thereof |
CN108883091A (zh) | 2015-12-22 | 2018-11-23 | X4 制药有限公司 | 用于治疗免疫缺陷病的方法 |
CA3019394A1 (en) | 2016-04-08 | 2017-10-12 | X4 Pharmaceuticals, Inc. | Methods for treating cancer |
JP6994767B2 (ja) | 2016-06-21 | 2022-01-14 | エックス4 ファーマシューティカルズ, インコーポレイテッド | Cxcr4阻害剤およびその使用 |
EP3808748A1 (en) | 2016-06-21 | 2021-04-21 | X4 Pharmaceuticals, Inc. | Substituted piperidines as cxcr4-inhibitors |
CA3027495A1 (en) | 2016-06-21 | 2017-12-28 | X4 Pharmaceuticals, Inc. | Cxcr4 inhibitors and uses thereof |
WO2018106738A1 (en) | 2016-12-05 | 2018-06-14 | Massachusetts Institute Of Technology | Brush-arm star polymers, conjugates and particles, and uses thereof |
CA3079405A1 (en) | 2017-10-31 | 2019-05-09 | Magenta Therapeutics Inc. | Compositions and methods for the expansion of hematopoietic stem and progenitor cells |
JP2021503008A (ja) | 2017-10-31 | 2021-02-04 | マジェンタ セラピューティクス インコーポレイテッドMagenta Therapeutics, Inc. | 造血幹細胞および前駆細胞移植療法のための組成物および方法 |
EP3720494A2 (en) | 2017-12-06 | 2020-10-14 | Magenta Therapeutics, Inc. | Dosing regimens for the mobilization of hematopoietic stem and progenitor cells |
US11260079B2 (en) | 2017-12-06 | 2022-03-01 | Magenta Therapeutics, Inc. | Dosing regimens for the mobilization of hematopoietic stem and progenitor cells |
CA3087527A1 (en) | 2018-01-03 | 2019-07-11 | Magenta Therapeutics, Inc. | Compositions and methods for the expansion of hematopoietic stem and progenitor cells and treatment of inherited metabolic disorders |
US10548889B1 (en) | 2018-08-31 | 2020-02-04 | X4 Pharmaceuticals, Inc. | Compositions of CXCR4 inhibitors and methods of preparation and use |
WO2020112195A1 (en) | 2018-11-30 | 2020-06-04 | Yale University | Compositions, technologies and methods of using plerixafor to enhance gene editing |
US20220401481A1 (en) | 2019-11-01 | 2022-12-22 | Magenta Therapeutics, Inc. | Dosing regimens for the mobilization of hematopoietic stem and progenitor cells |
CN115997009A (zh) | 2020-04-27 | 2023-04-21 | 美真达治疗公司 | 用于在体内转导造血干细胞和祖细胞的方法和组合物 |
EP4308694A1 (en) | 2021-03-16 | 2024-01-24 | Magenta Therapeutics, Inc. | Dosing regimens for hematopoietic stem cell mobilization for stem cell transplants in multiple myeloma patients |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4156683A (en) * | 1973-03-26 | 1979-05-29 | Schering Corporation | Complexes of macrocyclic compounds |
FR2614020B1 (fr) * | 1987-04-14 | 1989-07-28 | Guerbet Sa | Nouveaux ligands cycliques azotes, complexes metalliques formes par ces ligands, compositions de diagnostic contenant ces complexes et procede de preparation des ligands. |
DE3713842A1 (de) * | 1987-04-22 | 1988-11-17 | Schering Ag | Substituierte cyclische komplexbildner, komplexe und komplexsalze, verfahren zu deren herstellung und diese enthaltende pharmazeutische mittel |
DE4035760A1 (de) * | 1990-11-08 | 1992-05-14 | Schering Ag | Mono-n-substituierte 1,4,7,10-tetraazacyclododecan-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel |
-
1989
- 1989-12-21 US US07/454,418 patent/US5021409A/en not_active Expired - Lifetime
-
1990
- 1990-12-14 NZ NZ236463A patent/NZ236463A/en unknown
- 1990-12-14 AU AU68090/90A patent/AU639514B2/en not_active Ceased
- 1990-12-14 CA CA002032261A patent/CA2032261C/en not_active Expired - Lifetime
- 1990-12-14 IL IL9666690A patent/IL96666A/en not_active IP Right Cessation
- 1990-12-18 ZA ZA9010184A patent/ZA9010184B/xx unknown
- 1990-12-19 DK DK90313899.8T patent/DK0434385T3/da active
- 1990-12-19 EP EP90313899A patent/EP0434385B1/en not_active Expired - Lifetime
- 1990-12-19 DE DE69023748T patent/DE69023748T2/de not_active Expired - Lifetime
- 1990-12-19 KR KR1019900021096A patent/KR0180019B1/ko not_active IP Right Cessation
- 1990-12-19 AT AT90313899T patent/ATE130514T1/de not_active IP Right Cessation
- 1990-12-19 ES ES90313899T patent/ES2079453T3/es not_active Expired - Lifetime
- 1990-12-20 IE IE461990A patent/IE71640B1/en not_active IP Right Cessation
- 1990-12-20 HU HU908367A patent/HUT67031A/hu unknown
- 1990-12-20 PT PT96289A patent/PT96289B/pt not_active IP Right Cessation
- 1990-12-21 JP JP02404955A patent/JP3133345B2/ja not_active Expired - Lifetime
-
1994
- 1994-07-11 HU HU94P/P00011P patent/HU210534A9/hu unknown
-
1995
- 1995-11-23 GR GR950403260T patent/GR3018206T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
EP0434385B1 (en) | 1995-11-22 |
PT96289B (pt) | 1998-06-30 |
AU6809090A (en) | 1991-06-27 |
IL96666A0 (en) | 1991-09-16 |
CA2032261C (en) | 2002-04-23 |
ES2079453T3 (es) | 1996-01-16 |
ATE130514T1 (de) | 1995-12-15 |
HUT67031A (en) | 1995-01-30 |
US5021409A (en) | 1991-06-04 |
HU908367D0 (en) | 1991-07-29 |
EP0434385A3 (en) | 1992-03-04 |
JP3133345B2 (ja) | 2001-02-05 |
IE904619A1 (en) | 1991-07-17 |
JPH06219945A (ja) | 1994-08-09 |
IE71640B1 (en) | 1997-02-26 |
KR910011267A (ko) | 1991-08-07 |
AU639514B2 (en) | 1993-07-29 |
EP0434385A2 (en) | 1991-06-26 |
DE69023748T2 (de) | 1996-05-02 |
ZA9010184B (en) | 1991-11-27 |
KR0180019B1 (ko) | 1999-03-20 |
PT96289A (pt) | 1991-10-15 |
NZ236463A (en) | 1992-04-28 |
CA2032261A1 (en) | 1991-06-22 |
DK0434385T3 (da) | 1995-12-18 |
DE69023748D1 (de) | 1996-01-04 |
IL96666A (en) | 1996-01-31 |
HU210534A9 (en) | 1995-04-28 |
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