GR3006802T3 - - Google Patents

Info

Publication number
GR3006802T3
GR3006802T3 GR930400057T GR930400057T GR3006802T3 GR 3006802 T3 GR3006802 T3 GR 3006802T3 GR 930400057 T GR930400057 T GR 930400057T GR 930400057 T GR930400057 T GR 930400057T GR 3006802 T3 GR3006802 T3 GR 3006802T3
Authority
GR
Greece
Application number
GR930400057T
Other languages
Greek (el)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of GR3006802T3 publication Critical patent/GR3006802T3/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Indole Compounds (AREA)
GR930400057T 1986-06-13 1993-01-14 GR3006802T3 (en:Method)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US87375486A 1986-06-13 1986-06-13
AT0269187A AT398425B (de) 1986-06-13 1987-10-12 Neue tricyclische lactame

Publications (1)

Publication Number Publication Date
GR3006802T3 true GR3006802T3 (en:Method) 1993-06-30

Family

ID=25598925

Family Applications (1)

Application Number Title Priority Date Filing Date
GR930400057T GR3006802T3 (en:Method) 1986-06-13 1993-01-14

Country Status (12)

Country Link
EP (1) EP0249223B1 (en:Method)
JP (1) JP2542213B2 (en:Method)
KR (1) KR950014572B1 (en:Method)
AR (1) AR247213A1 (en:Method)
AT (1) AT398425B (en:Method)
AU (1) AU601433B2 (en:Method)
CA (1) CA1337654C (en:Method)
DK (1) DK170840B1 (en:Method)
ES (1) ES2044870T3 (en:Method)
GR (1) GR3006802T3 (en:Method)
IE (1) IE61476B1 (en:Method)
ZA (1) ZA874107B (en:Method)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4824832A (en) * 1987-12-30 1989-04-25 Merrell Dow Pharmaceuticals Inc. Sulfhydryl containing tricyclic lactams and their pharmacological methods of use
CA2053340C (en) * 1990-10-18 2002-04-02 Timothy P. Burkholder Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace
ES2108027T3 (es) * 1990-12-21 1997-12-16 Merrell Pharma Inc Nuevos compuestos triciclicos que contienen amino y nitro, utiles como inhibidores de ace.
US5208230A (en) * 1990-12-21 1993-05-04 Merrell Dow Pharmaceuticals Amino and nitro containing tricyclic compounds useful as inhibitors of ACE
ZA927211B (en) * 1991-09-27 1993-03-24 Merrell Dow Pharma Novel carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE.
US5455242A (en) * 1991-09-27 1995-10-03 Merrell Dow Pharmaceuticals Inc. Carboxyalkyl tricyclic derivatives useful as inhibitors of enkephalinase and ace
AU657793B2 (en) * 1991-09-27 1995-03-23 Merrell Pharmaceuticals Inc. Novel 2-substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE
DK0534363T3 (da) * 1991-09-27 1997-09-22 Merrell Pharma Inc 2-substituerede indan-2-mercaptoacetylamid-forbindelse med inhiberende virkning på enkephalinase og ACE.
US5457196A (en) * 1991-09-27 1995-10-10 Merrell Dow Pharmaceuticals Inc. 2-substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE
EP0625987B1 (en) * 1992-02-14 1998-04-01 Merrell Pharmaceuticals Inc. Aminoacetylmercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace
US5646276A (en) * 1992-05-13 1997-07-08 Bristol-Myers Squibb Co. Diazepine containing dual action inhibitors
US5552397A (en) * 1992-05-18 1996-09-03 E. R. Squibb & Sons, Inc. Substituted azepinone dual inhibitors of angiotensin converting enzyme and neutral exdopeptidase
AU669364B2 (en) * 1992-05-15 1996-06-06 Merrell Pharmaceuticals Inc. Novel mercaptoacetylamido pyridazo(1,2)pyridazine, pyrazolo(1,2)pyridazine, pyridazo(1,2-a)(1,2)diazepine and pyrazolo(1,2-a)(1,2)diazepine derivatives useful as inhibitors of enkephalinase and ace
US5238932A (en) * 1992-05-20 1993-08-24 Merrell Dow Pharmaceuticals Inc. Mercaptoacetylamide tricyclic derivatives useful as inhibitors of enkephalinase
HUT71243A (en) * 1992-10-30 1995-11-28 Merrell Pharma Inc Mercaptoacetylamide bicyclic lactam derivatives, process for producing them and pharmaceutical compositions of enkephalinase and ace inhibitor activity containing said compounds
US5362727A (en) * 1993-07-26 1994-11-08 Bristol-Myers Squibb Substituted azepino[2,1-a]isoquinoline compounds
DK0729456T3 (da) * 1993-11-19 1998-03-30 Merrell Pharma Inc Ny fremgangsmåde til fremstilling af (S)-1-(2(S)-(1,3-dihydro-1,3-dioxo-isoindol-2-yl)-1-oxo-3-phenylpropyl)-1,2,3,4-tetrahydro-2-pyridincarboxylsyremethylester og mellemprodukter derfor
KR100348949B1 (ko) * 1994-02-14 2003-01-24 메렐 파마슈티칼스 인크. 엔케팔리나제의억제제로서유용한신규의인단-2-머캅토아세틸아미드디술파이드유도체
EP0746566A1 (en) * 1994-02-14 1996-12-11 Merrell Pharmaceuticals Inc. Novel 2-substituted indane-2-mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase and ace
US5530013A (en) * 1994-02-14 1996-06-25 American Home Products Corporation Venlafaxine in the inducement of cognition enhancement
CN1100785C (zh) * 1994-02-14 2003-02-05 默里尔药物公司 1,3,4,5－四氢苯并[c]氮杂䓬－3－酮二硫化物衍生物及方法
NZ279012A (en) * 1994-02-14 1998-03-25 Merrell Pharma Inc Condensed benzazepine derivatives and medicaments
US5484783A (en) * 1994-03-24 1996-01-16 Merrell Dow Pharmaceuticals Inc. Hypocholesterolemic, antiatherosclerotic and hypotriglyceridemic mercaptoacetylamide and benzazapine derivatives
ATE189392T1 (de) * 1994-03-24 2000-02-15 Merrell Pharma Inc Hypocholesterolemische, antiatherosklerotische und hypotriglyceridemische verwendung von aminoacetylmercapto derivaten
ATE246927T1 (de) * 1994-03-24 2003-08-15 Merrell Pharma Inc Cholesterin senkende mercaptoacetylamiddisulfidderivate
US5641880A (en) * 1994-12-21 1997-06-24 Hoechst Marion Roussel, Inc. Processes for preparing intermediates of inhibitors of enkephalinase and angiotensin converting enzyme and intermediates thereof
ATE190315T1 (de) * 1994-12-21 2000-03-15 Hoechst Marion Roussel Inc Verfahren zur herstellung von zwischenprodukten von inhibitoren der enkephalinase und des angiotensin konvertierenden enzyms und zwischenprodukte davon
US5587375A (en) * 1995-02-17 1996-12-24 Bristol-Myers Squibb Company Azepinone compounds useful in the inhibition of ACE and NEP
US5877313A (en) * 1995-05-17 1999-03-02 Bristol-Myers Squibb Benzo-fused azepinone and piperidinone compounds useful in the inhibition of ACE and NEP
US5650408A (en) * 1995-06-07 1997-07-22 Karanewsky; Donald S. Thiazolo benzazepine containing dual action inhibitors
US5635504A (en) * 1995-06-07 1997-06-03 Bristol-Myers Squibb Co. Diazepine containing dual action inhibitors
GB0119305D0 (en) 2001-04-12 2001-10-03 Aventis Pharma Gmbh Mercaptoacetylamide derivatives,a process for their preparation and their use

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0107095B1 (en) * 1982-09-30 1987-09-09 Merck & Co. Inc. 1-n-alkylcarboxy-benzofused lactams useful as antihypertensive agents
EP0166357A3 (en) * 1984-06-26 1988-10-26 Merck & Co. Inc. Benzofused lactams and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
EP0249223A3 (en) 1989-01-25
ES2044870T3 (es) 1994-01-16
JPS62298591A (ja) 1987-12-25
CA1337654C (en) 1995-11-28
AU601433B2 (en) 1990-09-13
IE871547L (en) 1987-12-13
DK170840B1 (da) 1996-02-05
EP0249223B1 (en) 1992-10-14
AR247213A1 (es) 1994-11-30
ATA269187A (de) 1994-04-15
AT398425B (de) 1994-12-27
ZA874107B (en:Method) 1987-12-09
DK300487A (da) 1987-12-14
KR950014572B1 (ko) 1995-12-08
JP2542213B2 (ja) 1996-10-09
EP0249223A2 (en) 1987-12-16
IE61476B1 (en) 1994-11-02
DK300487D0 (da) 1987-06-12
KR880000399A (ko) 1988-03-25
AU7402287A (en) 1987-12-17

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