GR1001065B - Πολυπεπτιδικα αναλογα της απολιποπρωτεινης ε,διαγνωστικα συστηματα και μεθοδοι χρησιμοποιησεως αυτων. - Google Patents
Πολυπεπτιδικα αναλογα της απολιποπρωτεινης ε,διαγνωστικα συστηματα και μεθοδοι χρησιμοποιησεως αυτων.Info
- Publication number
- GR1001065B GR1001065B GR900100621A GR900100621A GR1001065B GR 1001065 B GR1001065 B GR 1001065B GR 900100621 A GR900100621 A GR 900100621A GR 900100621 A GR900100621 A GR 900100621A GR 1001065 B GR1001065 B GR 1001065B
- Authority
- GR
- Greece
- Prior art keywords
- polypeptide
- analogs
- methods
- diagnostic systems
- apolipoprotein
- Prior art date
Links
- 229920001184 polypeptide Polymers 0.000 title abstract 5
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 5
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 3
- 102100029470 Apolipoprotein E Human genes 0.000 title 1
- 101710095339 Apolipoprotein E Proteins 0.000 title 1
- 102000013918 Apolipoproteins E Human genes 0.000 abstract 2
- 108010025628 Apolipoproteins E Proteins 0.000 abstract 2
- 206010020961 Hypocholesterolaemia Diseases 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 210000001124 body fluid Anatomy 0.000 abstract 1
- 239000010839 body fluid Substances 0.000 abstract 1
- 230000003915 cell function Effects 0.000 abstract 1
- 230000000593 degrading effect Effects 0.000 abstract 1
- 238000001514 detection method Methods 0.000 abstract 1
- 230000036470 plasma concentration Effects 0.000 abstract 1
- 230000002792 vascular Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/775—Apolipopeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Obesity (AREA)
- Transplantation (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Connection Of Plates (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Η παρούσα εφεύρεσις αφορά εις πολυμερές πολυπεπτίδιον δυνάμενον να μιμηθεί την ικανότητα της apo E να προκαλεί διαφοροποιημένην κυτταρικήν λειτουργίαν. Η επαναλαμβανόμενη μονάς του πολυπεπτιδίου έχει αλληλουχίαν ριζών αμινοξέων αντιστοιχούσαν εις την αντιπροσωπευομένην υπό του τύπου LRKLRKRLLRDADDL. Θεωρείται επίσης μέθοδος θεραπείας της υπεχοληστεριναιμίας εις ασθενή, περιλαμβάνουσα την χορήγησιν εις τον ασθενή μιας υποβιβαζούσης την εις το πλάσμα συγκέντρωσιν της LDL ποσότητος του πολυπεπτιδίου. Περιγράφεται επίσης η χρήσις του πολυπεπτιδίου εις την παρασκευήν διαγνωστικών αντισωμάτων και η χρήσις αυτών εις διαγνωστικά συστήματα και μεθόδους ανιχνεύσεως αντιγόνων apo E εις αγγειακά υγρά του σώματος. ω
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/395,732 US5177189A (en) | 1989-08-18 | 1989-08-18 | Polypeptide analogs of Apolipoprotein E |
US07/485,158 US5182364A (en) | 1990-02-26 | 1990-02-26 | Polypeptide analogs of apolipoprotein E |
US07/540,363 US5168045A (en) | 1989-08-18 | 1990-06-18 | Diagnostic systems and methods using polypeptide analogs of apolipoprotein e |
Publications (2)
Publication Number | Publication Date |
---|---|
GR900100621A GR900100621A (en) | 1991-12-30 |
GR1001065B true GR1001065B (el) | 1993-04-28 |
Family
ID=27410184
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GR900100621A GR1001065B (el) | 1989-08-18 | 1990-08-17 | Πολυπεπτιδικα αναλογα της απολιποπρωτεινης ε,διαγνωστικα συστηματα και μεθοδοι χρησιμοποιησεως αυτων. |
Country Status (9)
Country | Link |
---|---|
US (1) | US5168045A (el) |
EP (1) | EP0487629A1 (el) |
JP (1) | JPH05501400A (el) |
AU (1) | AU648991B2 (el) |
FI (1) | FI920670A0 (el) |
GR (1) | GR1001065B (el) |
IE (1) | IE902992A1 (el) |
PT (1) | PT95030A (el) |
WO (1) | WO1991002751A1 (el) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5473039A (en) * | 1989-08-18 | 1995-12-05 | The Scripps Research Institute | Polypeptide analogs of apolipoprotein E, diagnostic systems and methods using the analogs |
CA2137814A1 (en) * | 1992-06-12 | 1993-12-23 | Maryvonne Rosseneu | New peptides and proteins, process for their preparation and their use as cholesterol acceptors |
WO1994004178A1 (en) * | 1992-08-12 | 1994-03-03 | Bio-Technology General Corp. | Method of inhibiting cell proliferation using apolipoprotein e |
JP3265577B2 (ja) * | 1992-10-13 | 2002-03-11 | デューク・ユニバーシティ | アポリポ蛋白eの4型イソ型の測定法 |
US20030077641A1 (en) * | 1998-03-11 | 2003-04-24 | Laskowitz Daniel T. | Methods of suppressing microglial activation and systemic inflammatory responses |
US7205280B2 (en) * | 1998-03-11 | 2007-04-17 | Cognosci, Inc. | Methods of suppressing microglial activation |
EA037404B1 (ru) | 2008-11-10 | 2021-03-24 | Арбутус Биофарма Корпорэйшн | Липиды и композиции для доставки лекарственных средств |
ITTO20080894A1 (it) * | 2008-12-02 | 2010-06-03 | Bioindustry Park Del Canavese S P A | Uso dell'aptoglobina, peptidi leganti l'aptoglobina, polimeri contenenti gli stessi e loro uso |
CA3036963A1 (en) | 2009-01-29 | 2010-08-05 | Arbutus Biopharma Corporation | Lipid formulations comprising cationic lipid and a targeting lipid comprising n-acetyl galactosamine for delivery of nucleic acid |
AU2010223967B2 (en) | 2009-03-12 | 2015-07-30 | Alnylam Pharmaceuticals, Inc. | Lipid formulated compositions and methods for inhibiting expression of Eg5 and VEGF genes |
NZ596186A (en) | 2009-05-05 | 2014-03-28 | Alnylam Pharmaceuticals Inc | Lipid compositions |
NZ712719A (en) | 2009-06-10 | 2017-03-31 | Arbutus Biopharma Corp | Improved lipid formulation |
BR112012000908A2 (pt) | 2009-07-14 | 2019-09-24 | Mayo Found Medical Education & Res | liberação de agentes ativos através da barreira hematoencefálica mediada por peptídeo em associação não covalente |
WO2011020023A2 (en) | 2009-08-14 | 2011-02-17 | Alnylam Pharmaceuticals, Inc. | Lipid formulated compositions and methods for inhibiting expression of a gene from the ebola virus |
CA2783372C (en) | 2009-12-07 | 2019-07-16 | Muthiah Manoharan | Compositions for nucleic acid delivery |
WO2011075656A1 (en) | 2009-12-18 | 2011-06-23 | The University Of British Columbia | Methods and compositions for delivery of nucleic acids |
WO2011139911A2 (en) | 2010-04-29 | 2011-11-10 | Isis Pharmaceuticals, Inc. | Lipid formulated single stranded rna |
US10077232B2 (en) | 2010-05-12 | 2018-09-18 | Arbutus Biopharma Corporation | Cyclic cationic lipids and methods of use |
JP2013527856A (ja) | 2010-05-12 | 2013-07-04 | プロチバ バイオセラピューティクス インコーポレイティッド | 陽イオン性脂質およびその使用方法 |
EP2575764B1 (en) | 2010-06-03 | 2017-04-19 | Alnylam Pharmaceuticals, Inc. | Biodegradable lipids for the delivery of active agents |
WO2012016184A2 (en) | 2010-07-30 | 2012-02-02 | Alnylam Pharmaceuticals, Inc. | Methods and compositions for delivery of active agents |
WO2012016188A2 (en) | 2010-07-30 | 2012-02-02 | Alnylam Pharmaceuticals, Inc. | Methods and compositions for delivery of active agents |
US9339513B2 (en) | 2010-11-09 | 2016-05-17 | Alnylam Pharmaceuticals, Inc. | Lipid formulated compositions and methods for inhibiting expression of Eg5 and VEGF genes |
EP3202760B1 (en) | 2011-01-11 | 2019-08-21 | Alnylam Pharmaceuticals, Inc. | Pegylated lipids and their use for drug delivery |
AU2012315965A1 (en) | 2011-09-27 | 2014-04-03 | Alnylam Pharmaceuticals, Inc. | Di-aliphatic substituted PEGylated lipids |
US9610324B2 (en) | 2012-07-11 | 2017-04-04 | Esperion Therapeutics, Inc. | Apolipoprotein mixtures |
US10072065B2 (en) | 2015-08-24 | 2018-09-11 | Mayo Foundation For Medical Education And Research | Peptide-mediated delivery of immunoglobulins across the blood-brain barrier |
CN112375138B (zh) * | 2020-11-13 | 2022-12-13 | 中元汇吉生物技术股份有限公司 | 一种重组载脂蛋白e和应用 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4483793A (en) * | 1982-10-04 | 1984-11-20 | The Regents Of The University Of California | Dimeric oligopeptides as heptenic epitopic sites for hepatitis |
US4643988A (en) * | 1984-05-15 | 1987-02-17 | Research Corporation | Amphipathic peptides |
US4970144A (en) * | 1984-12-31 | 1990-11-13 | International Genetic Engineering | Peptide fragments of human apolipoprotein, type-specific antibodies and methods of use |
US4677057A (en) * | 1985-03-11 | 1987-06-30 | Scripps Clinic And Research Foundation | Diagnostic assay for the presence of apolipoproteins associated with plasma high density lipoproteins |
SE448324B (sv) * | 1985-09-27 | 1987-02-09 | Pharmacia Ab | Sett vid immunkemisk bestemning av lipoproteiner och apolipoproteiner |
US4828986A (en) * | 1986-09-29 | 1989-05-09 | Scripps Clinic And Research Foundation | Assay method and diagnostic system for determining the ratio of APO B-100 to APO A-I in a blood sample |
ZA884504B (en) * | 1987-06-29 | 1989-03-29 | Merrell Dow Pharma | Immunosuppressant peptides |
-
1990
- 1990-06-18 US US07/540,363 patent/US5168045A/en not_active Expired - Fee Related
- 1990-08-17 GR GR900100621A patent/GR1001065B/el unknown
- 1990-08-17 JP JP2512512A patent/JPH05501400A/ja active Pending
- 1990-08-17 IE IE299290A patent/IE902992A1/en unknown
- 1990-08-17 EP EP90913358A patent/EP0487629A1/en not_active Ceased
- 1990-08-17 AU AU63370/90A patent/AU648991B2/en not_active Ceased
- 1990-08-17 PT PT95030A patent/PT95030A/pt not_active Application Discontinuation
- 1990-08-17 WO PCT/US1990/004651 patent/WO1991002751A1/en not_active Application Discontinuation
-
1992
- 1992-02-17 FI FI920670A patent/FI920670A0/fi not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
JPH05501400A (ja) | 1993-03-18 |
US5168045A (en) | 1992-12-01 |
EP0487629A1 (en) | 1992-06-03 |
IE902992A1 (en) | 1991-02-27 |
WO1991002751A1 (en) | 1991-03-07 |
PT95030A (pt) | 1991-04-18 |
FI920670A0 (fi) | 1992-02-17 |
GR900100621A (en) | 1991-12-30 |
AU6337090A (en) | 1991-04-03 |
AU648991B2 (en) | 1994-05-12 |
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