GR1000604B - Μεθοδος για την παρασκευη γλυκοσυλιωμενων ινσουλινων και συνδιασμων αυτων. - Google Patents

Μεθοδος για την παρασκευη γλυκοσυλιωμενων ινσουλινων και συνδιασμων αυτων.

Info

Publication number
GR1000604B
GR1000604B GR900100159A GR900100159A GR1000604B GR 1000604 B GR1000604 B GR 1000604B GR 900100159 A GR900100159 A GR 900100159A GR 900100159 A GR900100159 A GR 900100159A GR 1000604 B GR1000604 B GR 1000604B
Authority
GR
Greece
Prior art keywords
insulins
glykosylized
intervention
connections
glycosylated
Prior art date
Application number
GR900100159A
Other languages
English (en)
Other versions
GR900100159A (en
Inventor
Broberg John Halstrom
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Publication of GR900100159A publication Critical patent/GR900100159A/el
Publication of GR1000604B publication Critical patent/GR1000604B/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Endocrinology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)

Abstract

Παρέχονται ειδικά γλυκοσυλιωμένες ινσουλίνες και φαρμακευτικά παρασκευάσματά τους. Οι νέες ινσουλίνες κατά προτίμηση θα είναι μονο-, δι- ή τρι-γλυκοσυλιωμένες και θα περιέχουν μια ομάδα μονοσακχαρίδιου ή μια ομάδα ολιγοσακχαρίδιου με δύο ή τρεις μονάδες σακχάρων. Οι ειδικά γλυκοσυλιωμένες ινσουλίνες θα έχουν υψηλή διαλυτότητα και μια ταχύτερη εμφάνιση της δράσης ινσουλίνης από για παράδειγμα την ανθρώπινη ινσουλίνη. ω
GR900100159A 1989-03-08 1990-03-07 Μεθοδος για την παρασκευη γλυκοσυλιωμενων ινσουλινων και συνδιασμων αυτων. GR1000604B (el)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK111489A DK111489D0 (da) 1989-03-08 1989-03-08 Peptider

Publications (2)

Publication Number Publication Date
GR900100159A GR900100159A (en) 1990-07-31
GR1000604B true GR1000604B (el) 1992-08-26

Family

ID=8101165

Family Applications (1)

Application Number Title Priority Date Filing Date
GR900100159A GR1000604B (el) 1989-03-08 1990-03-07 Μεθοδος για την παρασκευη γλυκοσυλιωμενων ινσουλινων και συνδιασμων αυτων.

Country Status (19)

Country Link
EP (1) EP0462192A1 (el)
JP (1) JPH04504117A (el)
KR (1) KR920701249A (el)
CN (1) CN1045586A (el)
AU (1) AU638701B2 (el)
CA (1) CA2049937A1 (el)
CS (1) CS114290A3 (el)
DD (1) DD296933A5 (el)
DK (1) DK111489D0 (el)
FI (1) FI914226A0 (el)
GR (1) GR1000604B (el)
HU (1) HUT59942A (el)
IL (1) IL93674A0 (el)
NO (1) NO913517L (el)
NZ (1) NZ232808A (el)
PT (1) PT93366A (el)
WO (1) WO1990010645A1 (el)
YU (1) YU45490A (el)
ZA (1) ZA901737B (el)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1708755B1 (en) 2004-01-21 2012-03-21 Novo Nordisk Health Care AG Transglutaminase mediated conjugation of peptides
US7597884B2 (en) 2004-08-09 2009-10-06 Alios Biopharma, Inc. Hyperglycosylated polypeptide variants and methods of use
JP2012516339A (ja) 2009-01-28 2012-07-19 スマートセルズ・インコーポレイテツド 外因的刺激型制御放出物質体およびその使用
CN102341409A (zh) 2009-01-28 2012-02-01 斯马特塞尔斯公司 结晶胰岛素-缀合物
SG173112A1 (en) 2009-01-28 2011-08-29 Smartcells Inc Conjugate based systems for controlled drug delivery
CA2754950A1 (en) 2009-03-20 2010-09-23 Smartcells, Inc. Terminally-functionalized conjugates and uses thereof
EP2408470A4 (en) 2009-03-20 2012-08-29 Smartcells Inc SOLUBLE NONDEPOT INSULIN CONJUGATE AND ITS USE
US8933207B2 (en) 2010-07-28 2015-01-13 Smartcells, Inc. Drug-ligand conjugates, synthesis thereof, and intermediates thereto
AU2011282987A1 (en) 2010-07-28 2013-02-21 Smartcells, Inc. Recombinant lectins, binding-site modified lectins and uses thereof
JP2013535467A (ja) 2010-07-28 2013-09-12 スマートセルズ・インコーポレイテツド 組換えにより発現されたインスリンポリペプチドおよびその使用
US9624287B2 (en) 2012-07-17 2017-04-18 Case Western Reserve University O-linked carbohydrate-modified insulin analogues
EP2877200B1 (en) * 2012-07-17 2019-05-08 Case Western Reserve University O-linked carbohydrate-modified insulin analogues
CN104902922B (zh) * 2012-11-13 2017-12-12 阿道恰公司 包含经取代阴离子化合物的速效胰岛素制剂
CA2890048C (en) 2012-12-03 2022-05-03 Merck Sharp & Dohme Corp. O-glycosylated carboxy terminal portion (ctp) peptide-based insulin and insulin analogues
KR20150135332A (ko) 2013-03-14 2015-12-02 더 보드 오브 트러스티스 오브 더 리랜드 스탠포드 쥬니어 유니버시티 미토콘드리아 알데히드 탈수소효소-2 조절인자들 및 이들의 사용 방법
MX366852B (es) 2013-10-04 2019-07-25 Merck Sharp & Dohme Conjugados de insulina sensibles a glucosa.
US9795678B2 (en) 2014-05-14 2017-10-24 Adocia Fast-acting insulin composition comprising a substituted anionic compound and a polyanionic compound
FR3020947B1 (fr) 2014-05-14 2018-08-31 Adocia Composition aqueuse comprenant au moins une proteine et un agent solubilisant, sa preparation et ses utilisations
FR3043557B1 (fr) 2015-11-16 2019-05-31 Adocia Composition a action rapide d'insuline comprenant un citrate substitue
CN105709207A (zh) * 2016-01-29 2016-06-29 徐宝贞 一种用于治疗痛风的药物
CN105535927A (zh) * 2016-01-29 2016-05-04 山东中海制药有限公司 一种用于治疗流感、上呼吸道感染、病毒性肺炎的药物
CN105597080A (zh) 2016-01-29 2016-05-25 程潜 一种用于治疗尿毒症和尿蛋白的药物
RU2018147235A (ru) 2016-06-02 2020-07-10 Санофи Конъюгаты фармацевтического средства и фрагмента, способного связываться с глюкозочувствительным белком

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3847890A (en) * 1971-11-01 1974-11-12 A Green Acidic monosaccharide-substituted proteins
US4444683A (en) * 1982-11-17 1984-04-24 University Of Utah Glycosylated insulin derivatives
EP0119650A3 (en) * 1983-03-21 1987-09-30 THE PROCTER & GAMBLE COMPANY Galactosyl-insulin conjugates useful in treating diabetics
HU206890B (en) * 1986-10-13 1993-01-28 Sandoz Ag Process for producing sugar-modified somatostatin peptide derivatives and pharmaceutical compositions containing them as active components

Also Published As

Publication number Publication date
CA2049937A1 (en) 1990-09-09
CS114290A3 (en) 1992-02-19
DK111489D0 (da) 1989-03-08
NZ232808A (en) 1992-04-28
HU902787D0 (en) 1991-11-28
DD296933A5 (de) 1991-12-19
FI914226A7 (fi) 1991-09-06
AU638701B2 (en) 1993-07-08
ZA901737B (en) 1990-11-28
KR920701249A (ko) 1992-08-11
YU45490A (en) 1991-10-31
PT93366A (pt) 1990-11-07
HUT59942A (en) 1992-07-28
NO913517L (no) 1991-11-06
WO1990010645A1 (en) 1990-09-20
NO913517D0 (no) 1991-09-06
JPH04504117A (ja) 1992-07-23
GR900100159A (en) 1990-07-31
AU5280790A (en) 1990-10-09
IL93674A0 (en) 1990-12-23
FI914226A0 (fi) 1991-09-06
EP0462192A1 (en) 1991-12-27
CN1045586A (zh) 1990-09-26

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