GEP19960617B - Method for production of n-naphthoylglycine - Google Patents
Method for production of n-naphthoylglycineInfo
- Publication number
- GEP19960617B GEP19960617B GEAP19941918A GEAP1994001918A GEP19960617B GE P19960617 B GEP19960617 B GE P19960617B GE AP19941918 A GEAP19941918 A GE AP19941918A GE AP1994001918 A GEAP1994001918 A GE AP1994001918A GE P19960617 B GEP19960617 B GE P19960617B
- Authority
- GE
- Georgia
- Prior art keywords
- halo
- hydrogen
- lower alkoxy
- alkoxy
- substituents
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 9
- 229910052739 hydrogen Inorganic materials 0.000 abstract 5
- 239000001257 hydrogen Substances 0.000 abstract 5
- 125000001424 substituent group Chemical group 0.000 abstract 5
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000001475 halogen functional group Chemical group 0.000 abstract 3
- 125000001624 naphthyl group Chemical group 0.000 abstract 3
- YQHPVWRRSORYIV-UHFFFAOYSA-N 2-(naphthalene-1-carbonylamino)acetic acid Chemical class C1=CC=C2C(C(=O)NCC(=O)O)=CC=CC2=C1 YQHPVWRRSORYIV-UHFFFAOYSA-N 0.000 abstract 2
- 102000016912 Aldehyde Reductase Human genes 0.000 abstract 2
- 108010053754 Aldehyde reductase Proteins 0.000 abstract 2
- 150000002431 hydrogen Chemical group 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 239000012442 inert solvent Substances 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000003993 interaction Effects 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 229910052698 phosphorus Inorganic materials 0.000 abstract 1
- 239000011574 phosphorus Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C63/00—Compounds having carboxyl groups bound to a carbon atoms of six-membered aromatic rings
- C07C63/68—Compounds having carboxyl groups bound to a carbon atoms of six-membered aromatic rings containing halogen
- C07C63/72—Polycyclic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C65/21—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups
- C07C65/24—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups polycyclic
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Seasonings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Detergent Compositions (AREA)
- Cosmetics (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA000372119A CA1176269A (en) | 1981-03-02 | 1981-03-02 | N-naphthoylglycine derivatives |
| CA000387991A CA1191156A (en) | 1981-10-15 | 1981-10-15 | N-((6-(lower alkoxy)-5-(trifluoromethylthio)-1- naphthalenyl)-thioxomethyl)-n-(lower alkyl)glycines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GEP19960617B true GEP19960617B (en) | 1996-12-12 |
Family
ID=25669267
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GEAP19941918A GEP19960617B (en) | 1981-03-02 | 1994-05-16 | Method for production of n-naphthoylglycine |
Country Status (18)
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4446150A (en) * | 1982-09-21 | 1984-05-01 | Ayerst, Mckenna & Harrison, Inc. | Naphthalenylthiazole derivatives |
| FR2549474B1 (fr) * | 1983-07-19 | 1987-09-11 | Elf Aquitaine | Nouveaux thioamides, leurs preparation et applications |
| US4492706A (en) * | 1983-08-01 | 1985-01-08 | American Home Products Corporation | Method of lowering lipid levels |
| US4604406A (en) * | 1984-11-16 | 1986-08-05 | Ayerst, Mckenna & Harrison, Inc. | N-[6-methoxy-5-(perfluoroalkyl)-1-naphtholyl]-N-methylglycines and their thionaphthoyl analogs |
| US4663452A (en) * | 1985-08-29 | 1987-05-05 | Ethyl Corporation | Thiation process |
| US4734435A (en) * | 1986-04-07 | 1988-03-29 | American Home Products Corp. | N-[[6-methoxy-5-(trifluoromethyl)-1-naphthalenyl]-thioxomethyl]-N-methylglycine S-oxide and the amide thereof |
| JPS63119455A (ja) * | 1986-06-27 | 1988-05-24 | Nippon Shinyaku Co Ltd | グリシン誘導体 |
| CA1307537C (en) * | 1987-12-23 | 1992-09-15 | Jay E. Wrobel | N-naphthoylglycines as aldose reductase inhibitors |
| US4820727A (en) * | 1987-12-23 | 1989-04-11 | American Home Products Corporation | N-acyl-N-naphthoylglycines as aldose reductase inhibitors |
| DE4318069C1 (de) * | 1993-06-01 | 1994-03-31 | Cassella Ag | Verfahren zur Herstellung von 5-Brom-6-methoxy-1-naphthoesäuremethylester |
| DE19603329A1 (de) | 1996-01-31 | 1997-08-07 | Bayer Ag | Verfahren zur Herstellung von aromatischen Methoxycarbonsäuremethylestern |
| WO1998042324A2 (en) * | 1997-03-21 | 1998-10-01 | The Regents Of The University Of California | Methods for modulating neurotrophic factor-associated activity using aldose reductase inhibitors |
| US6696407B1 (en) | 1997-03-21 | 2004-02-24 | The Regents Of The University Of California | Huntington's disease treatment comprising administering aldose reductase inhibitors to increase striatal CNTF |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3821383A (en) * | 1972-07-10 | 1974-06-28 | Ayerst Mckenna & Harrison | Compositions for and a method of treating diabetic complications |
-
1982
- 1982-02-10 AU AU80342/82A patent/AU544067B2/en not_active Expired
- 1982-02-24 CY CY138582A patent/CY1385A/xx unknown
- 1982-02-24 EP EP82300940A patent/EP0059596B1/en not_active Expired
- 1982-02-24 DE DE8282300940T patent/DE3263225D1/de not_active Expired
- 1982-02-24 AT AT82300940T patent/ATE12932T1/de not_active IP Right Cessation
- 1982-02-25 PH PH26913A patent/PH17378A/en unknown
- 1982-03-01 IE IE448/82A patent/IE52604B1/en not_active IP Right Cessation
- 1982-03-01 DK DK089182A patent/DK160760C/da not_active IP Right Cessation
- 1982-03-01 ES ES510004A patent/ES510004A0/es active Granted
- 1982-03-01 HU HU82615A patent/HU188778B/hu unknown
- 1982-03-02 SU SU823462357A patent/SU1241985A3/ru active
- 1982-03-02 GR GR67447A patent/GR76037B/el unknown
-
1987
- 1987-05-15 SG SG44687A patent/SG44687G/en unknown
- 1987-06-05 DO DO1987004565A patent/DOP1987004565A/es unknown
- 1987-07-07 KE KE3737A patent/KE3737A/xx unknown
- 1987-10-29 HK HK809/87A patent/HK80987A/en not_active IP Right Cessation
- 1987-12-30 MY MY627/87A patent/MY8700627A/xx unknown
-
1994
- 1994-05-16 GE GEAP19941918A patent/GEP19960617B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES8307214A1 (es) | 1983-07-01 |
| EP0059596A1 (en) | 1982-09-08 |
| PH17378A (en) | 1984-08-06 |
| DK89182A (da) | 1982-09-03 |
| AU544067B2 (en) | 1985-05-16 |
| DE3263225D1 (de) | 1985-05-30 |
| ATE12932T1 (de) | 1985-05-15 |
| GR76037B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1984-08-03 |
| SU1241985A3 (ru) | 1986-06-30 |
| EP0059596B1 (en) | 1985-04-24 |
| IE52604B1 (en) | 1987-12-23 |
| AU8034282A (en) | 1982-09-09 |
| DK160760B (da) | 1991-04-15 |
| KE3737A (en) | 1987-09-04 |
| CY1385A (en) | 1987-12-18 |
| IE820448L (en) | 1982-09-02 |
| SG44687G (en) | 1987-07-24 |
| ES510004A0 (es) | 1983-07-01 |
| HU188778B (en) | 1986-05-28 |
| MY8700627A (en) | 1987-12-31 |
| HK80987A (en) | 1987-11-06 |
| DK160760C (da) | 1991-09-23 |
| DOP1987004565A (es) | 1997-10-28 |
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