GEP19960478B - Procprocess for preparing derivatives of chloroambucyl (modifications)ess for preparing derivatives of chloroambucyl (modifications) - Google Patents
Procprocess for preparing derivatives of chloroambucyl (modifications)ess for preparing derivatives of chloroambucyl (modifications)Info
- Publication number
- GEP19960478B GEP19960478B GEAP19942153A GEAP1994002153A GEP19960478B GE P19960478 B GEP19960478 B GE P19960478B GE AP19942153 A GEAP19942153 A GE AP19942153A GE AP1994002153 A GEAP1994002153 A GE AP1994002153A GE P19960478 B GEP19960478 B GE P19960478B
- Authority
- GE
- Georgia
- Prior art keywords
- chloroambucyl
- interaction
- organic solvent
- modifications
- oestradiol
- Prior art date
Links
- 238000012986 modification Methods 0.000 title 2
- 230000004048 modification Effects 0.000 title 2
- 230000003993 interaction Effects 0.000 abstract 4
- 239000003960 organic solvent Substances 0.000 abstract 4
- VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 abstract 3
- 241001597008 Nomeidae Species 0.000 abstract 3
- 229930182833 estradiol Natural products 0.000 abstract 2
- 239000012467 final product Substances 0.000 abstract 2
- 238000002955 isolation Methods 0.000 abstract 2
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 230000000118 anti-neoplastic effect Effects 0.000 abstract 1
- 239000011230 binding agent Substances 0.000 abstract 1
- KDPAWGWELVVRCH-UHFFFAOYSA-N bromoacetic acid Chemical compound OC(=O)CBr KDPAWGWELVVRCH-UHFFFAOYSA-N 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 230000007721 medicinal effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
- C07J1/007—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
- C07J1/0074—Esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0088—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing unsubstituted amino radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP53098795A JPS5810393B2 (ja) | 1978-08-14 | 1978-08-14 | 新規なエストラジオ−ル結合体とその製造方法及び抗腫瘍剤 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GEP19960478B true GEP19960478B (en) | 1996-08-29 |
Family
ID=14229286
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GEAP19942153A GEP19960478B (en) | 1978-08-14 | 1994-09-07 | Procprocess for preparing derivatives of chloroambucyl (modifications)ess for preparing derivatives of chloroambucyl (modifications) |
Country Status (8)
| Country | Link |
|---|---|
| JP (1) | JPS5810393B2 (cs) |
| BE (1) | BE878186A (cs) |
| CS (1) | CS242856B2 (cs) |
| GE (1) | GEP19960478B (cs) |
| HU (1) | HU180002B (cs) |
| SU (1) | SU1001860A3 (cs) |
| UA (1) | UA6043A1 (cs) |
| YU (1) | YU41345B (cs) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2169900B (en) * | 1984-06-27 | 1988-02-17 | Onkologi N Ct Ak Med V | Derivatives of steroids of androstane series |
-
1978
- 1978-08-14 JP JP53098795A patent/JPS5810393B2/ja not_active Expired
-
1979
- 1979-07-19 HU HU79KU545A patent/HU180002B/hu not_active IP Right Cessation
- 1979-08-10 BE BE0/196683A patent/BE878186A/fr not_active IP Right Cessation
- 1979-08-13 SU SU792804752A patent/SU1001860A3/ru active
- 1979-08-13 UA UA2804752A patent/UA6043A1/uk unknown
- 1979-08-14 CS CS795566A patent/CS242856B2/cs unknown
- 1979-08-14 YU YU1981/79A patent/YU41345B/xx unknown
-
1994
- 1994-09-07 GE GEAP19942153A patent/GEP19960478B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CS556679A2 (en) | 1985-08-15 |
| UA6043A1 (uk) | 1994-12-29 |
| YU198179A (en) | 1983-01-21 |
| JPS5810393B2 (ja) | 1983-02-25 |
| BE878186A (fr) | 1980-02-11 |
| JPS5527121A (en) | 1980-02-27 |
| CS242856B2 (en) | 1986-05-15 |
| YU41345B (en) | 1987-02-28 |
| SU1001860A3 (ru) | 1983-02-28 |
| HU180002B (en) | 1983-01-28 |
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