GB995370A - Novel tetrahydro-quinoline derivatives and the preparation thereof - Google Patents
Novel tetrahydro-quinoline derivatives and the preparation thereofInfo
- Publication number
- GB995370A GB995370A GB4492464A GB4492464A GB995370A GB 995370 A GB995370 A GB 995370A GB 4492464 A GB4492464 A GB 4492464A GB 4492464 A GB4492464 A GB 4492464A GB 995370 A GB995370 A GB 995370A
- Authority
- GB
- United Kingdom
- Prior art keywords
- isoquinoline
- halophenyl
- ethyl
- tetrahydro
- phenethylamine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/18—Aralkyl radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention comprises tetrahydro-isoquinoline derivatives of the formula <FORM:0995370/C2/1> wherein n stands for 1, 2 or 3, R1 is a halogen atom and R2 is a hydrogen atom or an alkyl group containing up to 4 carbon atoms. The compounds are prepared by condensing 3-benzyloxy - 4 - methoxy - phenethylamine or 3 - methoxy - 4 - benzyloxy - phenethylamine with a b -phenyl propionic acid which contains 1, 2 or 3 halogen atoms in the phenyl nucleus and which may also contain an alkyl group having up to 4 carbon atoms in the a -position, cyclizing the resulting N-[b -(substituted phenyl) ethyl]-b -(halophenyl)-propionic acid imide to the corresponding 1 - [b - (halophenyl)ethyl] - 3,4-dihydro-isoquinoline derivative by treatment with phosphorus oxychloride, reducing this compound with, for example, an alkali metal hydride and,finally, N-methylating the 1-[b - (halophenyl)ethyl] - 1,2,3,4 - tetrahydro-isoquinoline obtained. They may also be prepared by quaternizing a 3,4-dihydro-isoquinoline obtained as described above and subsequently reducing the quaternary derivative.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH65062A CH420086A (en) | 1962-01-19 | 1962-01-19 | Process for the preparation of tetrahydroisoquinoline derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
GB995370A true GB995370A (en) | 1965-06-16 |
Family
ID=4191946
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB4492464A Expired GB995370A (en) | 1962-01-19 | 1963-01-15 | Novel tetrahydro-quinoline derivatives and the preparation thereof |
GB177563A Expired GB995369A (en) | 1962-01-19 | 1963-01-15 | Novel tetrahydro-quinoline derivatives and a process for the manufacture thereof |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB177563A Expired GB995369A (en) | 1962-01-19 | 1963-01-15 | Novel tetrahydro-quinoline derivatives and a process for the manufacture thereof |
Country Status (5)
Country | Link |
---|---|
BE (1) | BE627177A (en) |
CH (1) | CH420086A (en) |
DE (1) | DE1445869A1 (en) |
DK (1) | DK108863C (en) |
GB (2) | GB995370A (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69410093T2 (en) * | 1993-06-22 | 1998-10-01 | Knoll Ag | ISOCHINOLINE DERIVATIVES WITH THERAPEUTIC EFFECT |
-
1962
- 1962-01-19 CH CH65062A patent/CH420086A/en unknown
- 1962-12-15 DE DE19621445869 patent/DE1445869A1/en active Pending
-
1963
- 1963-01-15 GB GB4492464A patent/GB995370A/en not_active Expired
- 1963-01-15 GB GB177563A patent/GB995369A/en not_active Expired
- 1963-01-16 BE BE627177A patent/BE627177A/en unknown
- 1963-01-18 DK DK23963A patent/DK108863C/en active
Also Published As
Publication number | Publication date |
---|---|
CH420086A (en) | 1966-09-15 |
DE1445869A1 (en) | 1969-04-10 |
GB995369A (en) | 1965-06-16 |
BE627177A (en) | 1963-07-16 |
DK108863C (en) | 1968-02-19 |
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