GB995369A - Novel tetrahydro-quinoline derivatives and a process for the manufacture thereof - Google Patents

Novel tetrahydro-quinoline derivatives and a process for the manufacture thereof

Info

Publication number
GB995369A
GB995369A GB177563A GB177563A GB995369A GB 995369 A GB995369 A GB 995369A GB 177563 A GB177563 A GB 177563A GB 177563 A GB177563 A GB 177563A GB 995369 A GB995369 A GB 995369A
Authority
GB
United Kingdom
Prior art keywords
carbon atoms
group containing
compound
formula
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB177563A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of GB995369A publication Critical patent/GB995369A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/18—Aralkyl radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention comprises tetrahydro-isoquinoline derivatives of the formula <FORM:0995369/C2/1> wherein n stands for 1, 2 or 3, R1 is a halogen atom and R2 is a hydrogen atom or an alkyl group containing up to 4 carbon atoms, and the corresponding compounds in which the hydroxyl group in the 6- or 7-position is replaced by an alkoxy group containing at least 2 carbon atoms or an acyloxy group, and acid-addition salts thereof. The compounds are prepared by reductively debenzylating, e.g. using hydrogen in the presence of a metal hydrogenation catalyst, a compound of the formula <FORM:0995369/C2/2> and, if desired, replacing the hydrogen atom of the hydroxyl group in the 6- or 7-position by an alkyl group containing at least 2 carbon atoms or an acyl group by etherification or esterification as the case may be, and also if desired, converting the product of any of the foregoing steps into an acid-addition salt. Pharmaceutical compositions for enteral and parenteral administration having analgesic, antitussive and antirheumatic activity comprise a compound of the invention together with a pharmaceutically acceptable carrier. They may be formulated as tablets, dragees, suppositories, capsules, solutions, suspensions or emulsions. Specification 995,370 is referred to.
GB177563A 1962-01-19 1963-01-15 Novel tetrahydro-quinoline derivatives and a process for the manufacture thereof Expired GB995369A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH65062A CH420086A (en) 1962-01-19 1962-01-19 Process for the preparation of tetrahydroisoquinoline derivatives

Publications (1)

Publication Number Publication Date
GB995369A true GB995369A (en) 1965-06-16

Family

ID=4191946

Family Applications (2)

Application Number Title Priority Date Filing Date
GB4492464A Expired GB995370A (en) 1962-01-19 1963-01-15 Novel tetrahydro-quinoline derivatives and the preparation thereof
GB177563A Expired GB995369A (en) 1962-01-19 1963-01-15 Novel tetrahydro-quinoline derivatives and a process for the manufacture thereof

Family Applications Before (1)

Application Number Title Priority Date Filing Date
GB4492464A Expired GB995370A (en) 1962-01-19 1963-01-15 Novel tetrahydro-quinoline derivatives and the preparation thereof

Country Status (5)

Country Link
BE (1) BE627177A (en)
CH (1) CH420086A (en)
DE (1) DE1445869A1 (en)
DK (1) DK108863C (en)
GB (2) GB995370A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5807868A (en) * 1993-06-22 1998-09-15 Knoll Aktiengesellschaft Isoquinoline derivatives as therapeutic agents

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5807868A (en) * 1993-06-22 1998-09-15 Knoll Aktiengesellschaft Isoquinoline derivatives as therapeutic agents

Also Published As

Publication number Publication date
DE1445869A1 (en) 1969-04-10
CH420086A (en) 1966-09-15
BE627177A (en) 1963-07-16
GB995370A (en) 1965-06-16
DK108863C (en) 1968-02-19

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