GB972081A - New phenthiazine compounds - Google Patents

New phenthiazine compounds

Info

Publication number
GB972081A
GB972081A GB4314859A GB4314859A GB972081A GB 972081 A GB972081 A GB 972081A GB 4314859 A GB4314859 A GB 4314859A GB 4314859 A GB4314859 A GB 4314859A GB 972081 A GB972081 A GB 972081A
Authority
GB
United Kingdom
Prior art keywords
formula
group
acid addition
compounds
cyano
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB4314859A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rhone Poulenc SA
Original Assignee
Rhone Poulenc SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc SA filed Critical Rhone Poulenc SA
Priority to GB4314859A priority Critical patent/GB972081A/en
Priority to LU39325D priority patent/LU39325A1/xx
Priority to ES0262816A priority patent/ES262816A1/en
Priority to CH1335060A priority patent/CH398605A/en
Priority to CH862865A priority patent/CH405318A/en
Publication of GB972081A publication Critical patent/GB972081A/en
Expired legal-status Critical Current

Links

Landscapes

  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)

Abstract

The invention comprises 10-dimethyl-amino-alkylphenothiazines of the general formula <FORM:0972081/C1/1> (wherein A represents the group -CH2-CH-(CH3)- or -CH2-CH(CH3)-CH2-), their acid addition salts (including salicylates), and quaternary ammonium salts and the preparation thereof by (a) converting the cyano group of a 3-cyano-phenothiazine of the formula <FORM:0972081/C1/2> into a formyl group (e.g. by reaction with triethoxyaluminium hydride and subsequent hydrolysis) or (b) catalytically hydrogenating the above 3-cyanophenothiazine in the presence of a semicarbazide acid addition salt and heating the semicarbazone so formed in the presence of pyruvic acid or (c) by decarboxylation of a compound of the formula <FORM:0972081/C1/3> Pharmaceutical compositions having anti-histamine activity comprise the compounds of the invention and a pharmaceutical carrier. The compositions may be formulated as tablets, pills, capsules, dispersible powders and granules, emulsions, solutions, suspensions, syrups, elixirs and suppositories. Specifications 805,886 and 816,582 are referred to. Reference has been directed by the Comptroller to Specification 816,582.
GB4314859A 1959-12-18 1959-12-18 New phenthiazine compounds Expired GB972081A (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
GB4314859A GB972081A (en) 1959-12-18 1959-12-18 New phenthiazine compounds
LU39325D LU39325A1 (en) 1959-12-18 1960-10-24
ES0262816A ES262816A1 (en) 1959-12-18 1960-11-28 New phenthiazine compounds
CH1335060A CH398605A (en) 1959-12-18 1960-11-29 Process for the preparation of novel derivatives of 3-formylphenothiazine
CH862865A CH405318A (en) 1959-12-18 1960-11-29 Process for the preparation of novel derivatives of 3-formylphenothiazine

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB4314859A GB972081A (en) 1959-12-18 1959-12-18 New phenthiazine compounds

Publications (1)

Publication Number Publication Date
GB972081A true GB972081A (en) 1964-10-07

Family

ID=10427521

Family Applications (1)

Application Number Title Priority Date Filing Date
GB4314859A Expired GB972081A (en) 1959-12-18 1959-12-18 New phenthiazine compounds

Country Status (4)

Country Link
CH (2) CH405318A (en)
ES (1) ES262816A1 (en)
GB (1) GB972081A (en)
LU (1) LU39325A1 (en)

Also Published As

Publication number Publication date
ES262816A1 (en) 1961-02-01
LU39325A1 (en) 1960-12-27
CH398605A (en) 1966-03-15
CH405318A (en) 1966-01-15

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