GB9711125D0 - Novel cyanoguanidines - Google Patents

Novel cyanoguanidines

Info

Publication number
GB9711125D0
GB9711125D0 GBGB9711125.6A GB9711125A GB9711125D0 GB 9711125 D0 GB9711125 D0 GB 9711125D0 GB 9711125 A GB9711125 A GB 9711125A GB 9711125 D0 GB9711125 D0 GB 9711125D0
Authority
GB
United Kingdom
Prior art keywords
stands
alkoxycarbonyl
trifluoromethyl
carboxy
cyano
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
GBGB9711125.6A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
PHARMACEUTICAL PROD Ltd
Leo Pharma AS
Original Assignee
PHARMACEUTICAL PROD Ltd
Leo Pharmaceutical Products Ltd AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by PHARMACEUTICAL PROD Ltd, Leo Pharmaceutical Products Ltd AS filed Critical PHARMACEUTICAL PROD Ltd
Priority to GBGB9711125.6A priority Critical patent/GB9711125D0/en
Publication of GB9711125D0 publication Critical patent/GB9711125D0/en
Priority to JP50011499A priority patent/JP4408455B2/ja
Priority to RU99128082/04A priority patent/RU2195453C2/ru
Priority to EP98924055A priority patent/EP0984938B1/en
Priority to AT98924055T priority patent/ATE249438T1/de
Priority to PL98337030A priority patent/PL190314B1/pl
Priority to AU76386/98A priority patent/AU733142B2/en
Priority to NZ501071A priority patent/NZ501071A/en
Priority to US09/424,632 priority patent/US6346541B1/en
Priority to RO99-01251A priority patent/RO120541B1/ro
Priority to HK00106580.3A priority patent/HK1027562B/xx
Priority to ES98924055T priority patent/ES2206932T3/es
Priority to DK98924055T priority patent/DK0984938T3/da
Priority to KR10-1999-7011131A priority patent/KR100496220B1/ko
Priority to PT98924055T priority patent/PT984938E/pt
Priority to CZ19994234A priority patent/CZ294842B6/cs
Priority to HU0002921A priority patent/HUP0002921A3/hu
Priority to CN98805595A priority patent/CN1116283C/zh
Priority to CA002292895A priority patent/CA2292895C/en
Priority to PCT/DK1998/000196 priority patent/WO1998054144A1/en
Priority to DE69818041T priority patent/DE69818041T2/de
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/26—Radicals substituted by halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/84—Nitriles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
GBGB9711125.6A 1997-05-29 1997-05-29 Novel cyanoguanidines Pending GB9711125D0 (en)

Priority Applications (21)

Application Number Priority Date Filing Date Title
GBGB9711125.6A GB9711125D0 (en) 1997-05-29 1997-05-29 Novel cyanoguanidines
DE69818041T DE69818041T2 (de) 1997-05-29 1998-05-15 Cyanoguanidine als zellproliferation inhibitoren
HK00106580.3A HK1027562B (en) 1997-05-29 1998-05-15 Cyanoguanidines as cell proliferation inhibitors
DK98924055T DK0984938T3 (da) 1997-05-29 1998-05-15 Cyanoguanidiner som celleproliferationsinhibitorer
EP98924055A EP0984938B1 (en) 1997-05-29 1998-05-15 Cyanoguanidines as cell proliferation inhibitors
AT98924055T ATE249438T1 (de) 1997-05-29 1998-05-15 Cyanoguanidine als zellproliferation inhibitoren
PL98337030A PL190314B1 (pl) 1997-05-29 1998-05-15 Cyjanoguanidyny jako inhibitory proliferacji komórki, preparat farmaceutyczny, sposób wytwarzania cyjanoguanidyn oraz ich zastosowanie
AU76386/98A AU733142B2 (en) 1997-05-29 1998-05-15 Cyanoguanidines as cell proliferation inhibitors
NZ501071A NZ501071A (en) 1997-05-29 1998-05-15 Cyanoguanidines such as N-cyano-N'-(5-phenylaminocarbonylpentyl)-N'-4-pyridylguanidine for treating skin cancer or cancer cells
US09/424,632 US6346541B1 (en) 1997-05-29 1998-05-15 Cyanoguanidines as cell proliferation inhibitors
RO99-01251A RO120541B1 (ro) 1997-05-29 1998-05-15 Derivaţi de cianoguanidină, ca inhibitori ai proliferării celulelor
JP50011499A JP4408455B2 (ja) 1997-05-29 1998-05-15 細胞増殖抑制剤としてのシアノグアニジン
ES98924055T ES2206932T3 (es) 1997-05-29 1998-05-15 Cianoguanidinas como inhibidores de la proliferacion celular.
RU99128082/04A RU2195453C2 (ru) 1997-05-29 1998-05-15 Цианогуанидины, способы их получения и фармацевтический препарат на их основе
KR10-1999-7011131A KR100496220B1 (ko) 1997-05-29 1998-05-15 세포 증식 억제제로서의 시아노구아니딘
PT98924055T PT984938E (pt) 1997-05-29 1998-05-15 Cianoguanidinas como inibidores da proliferacao celular
CZ19994234A CZ294842B6 (cs) 1997-05-29 1998-05-15 Kyanoguanidiny, způsob jejich přípravy a použití a farmaceutické přípravky s jejich obsahem
HU0002921A HUP0002921A3 (en) 1997-05-29 1998-05-15 Cyanoguanidines as cell proliferation inhibitors, process for producing them and pharmaceutical compositions containing them
CN98805595A CN1116283C (zh) 1997-05-29 1998-05-15 作为细胞增殖抑制剂的氰基胍
CA002292895A CA2292895C (en) 1997-05-29 1998-05-15 Cyanoguanidines as cell proliferation inhibitors
PCT/DK1998/000196 WO1998054144A1 (en) 1997-05-29 1998-05-15 Cyanoguanidines as cell proliferation inhibitors

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9711125.6A GB9711125D0 (en) 1997-05-29 1997-05-29 Novel cyanoguanidines

Publications (1)

Publication Number Publication Date
GB9711125D0 true GB9711125D0 (en) 1997-07-23

Family

ID=10813255

Family Applications (1)

Application Number Title Priority Date Filing Date
GBGB9711125.6A Pending GB9711125D0 (en) 1997-05-29 1997-05-29 Novel cyanoguanidines

Country Status (20)

Country Link
US (1) US6346541B1 (https=)
EP (1) EP0984938B1 (https=)
JP (1) JP4408455B2 (https=)
KR (1) KR100496220B1 (https=)
CN (1) CN1116283C (https=)
AT (1) ATE249438T1 (https=)
AU (1) AU733142B2 (https=)
CA (1) CA2292895C (https=)
CZ (1) CZ294842B6 (https=)
DE (1) DE69818041T2 (https=)
DK (1) DK0984938T3 (https=)
ES (1) ES2206932T3 (https=)
GB (1) GB9711125D0 (https=)
HU (1) HUP0002921A3 (https=)
NZ (1) NZ501071A (https=)
PL (1) PL190314B1 (https=)
PT (1) PT984938E (https=)
RO (1) RO120541B1 (https=)
RU (1) RU2195453C2 (https=)
WO (1) WO1998054144A1 (https=)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9711123D0 (en) * 1997-05-29 1997-07-23 Leo Pharm Prod Ltd Novel cyanoguanidines
AU4080300A (en) 1999-04-09 2000-11-14 Shionogi Bioresearch Corp. Cyanoguanidine compounds
AU1494702A (en) 2000-11-21 2002-06-03 Leo Pharma As Cyanoguanidine prodrugs
US20030045515A1 (en) * 2001-05-24 2003-03-06 Lise Binderup Combination medicament for treatment of neoplastic diseases
IL158574A0 (en) * 2001-05-24 2004-05-12 Leo Pharma As Novel pyridyl cyanoguanidine compounds
US7253193B2 (en) 2002-05-17 2007-08-07 Leo Pharma A/S Cyanoguanidine prodrugs
CA2485351C (en) * 2002-05-17 2011-12-06 Leo Pharma A/S Cyanoguanidine prodrugs
CA2484671A1 (en) * 2002-05-17 2003-11-27 Leo Pharma A/S Cyanoguanidine prodrugs
WO2006037468A1 (en) * 2004-09-30 2006-04-13 Istituto Di Ricerche Di Biologia Molecolare P Angeletti Spa Hiv reverse transcriptase inhibitors
JP5189367B2 (ja) * 2004-12-22 2013-04-24 レオ ファーマ アクティーゼルスカブ 新規シアノグアニジン化合物
WO2006110298A2 (en) * 2005-03-25 2006-10-19 Glaxo Group Limited 8-alkyl/aryl-4-aryl-2-n- (alkylamino)-n'-substituted-n'-cyanoguanidino-8h-pyrido[2,3-d]pyrimidin-7-one compounds and use thereof
CA2701071C (en) 2007-09-26 2018-03-27 Gemin X Pharmaceuticals Canada Inc. Compositions and methods for effecting nad+ levels using a nicotinamide phosphoribosyl transferase inhibitor
US8173677B2 (en) 2007-09-26 2012-05-08 Gemin X Pharmaceuticals Canada Inc. Compositions and methods for effecting NAD+ levels using a nicotinamide phosphoribosyl transferase inhibitor
WO2009086835A1 (en) * 2008-01-11 2009-07-16 Topotarget A/S Novel cyanoguanidines
JP5688367B2 (ja) * 2008-08-29 2015-03-25 トポターゲット・アクティーゼルスカブＴｏｐｏＴａｒｇｅｔ Ａ／Ｓ 新規なウレアおよびチオウレア誘導体
EP2394649A4 (en) 2009-02-06 2012-08-15 Tianjin Hemay Bio Tech Co Ltd PHARMACEUTICAL COMPOSITIONS CONTAINING PYRIDYL-CYANOGUANIDINES, PREPARATION METHODS AND USES THEREOF
US8912184B1 (en) 2010-03-01 2014-12-16 Alzheimer's Institute Of America, Inc. Therapeutic and diagnostic methods
CN106243023A (zh) 2010-09-03 2016-12-21 福马Tm有限责任公司 用于抑制nampt的胍化合物和组合物
EP2634173A4 (en) 2010-10-26 2014-04-02 Tianjin Hemay Bio Tech Co Ltd POLYMORPH OF N- (6- (4-CHLOROPHENOXY) HEXYL-) N'-CYANO-N '' - (4-PYRIDYL-) GUANIDINE, PREPARATION THEREOF AND USE THEREOF
TWI835714B (zh) 2016-10-18 2024-03-21 美商思進公司 菸鹼醯胺腺嘌呤二核苷酸補救合成(salvage pathway)抑制劑之靶向投遞
WO2018201087A1 (en) 2017-04-27 2018-11-01 Seattle Genetics, Inc. Quaternized nicotinamide adenine dinucleotide salvage pathway inhibitor conjugates

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4530693A (en) * 1992-08-13 1994-03-15 Upjohn Company, The Cyanoguanidines as potassium channel blockers
GB9219472D0 (en) * 1992-09-15 1992-10-28 Leo Pharm Prod Ltd Chemical compounds
DE69502584T2 (de) * 1994-01-28 1998-11-26 Pharmacia & Upjohn Co., Kalamazoo, Mich. 49001 Cyanoguanidine als k-kanal-blocker

Also Published As

Publication number Publication date
AU733142B2 (en) 2001-05-10
CZ294842B6 (cs) 2005-03-16
CN1258279A (zh) 2000-06-28
HUP0002921A3 (en) 2002-10-28
HUP0002921A2 (hu) 2001-01-29
HK1027562A1 (en) 2001-01-19
JP4408455B2 (ja) 2010-02-03
KR20010013148A (ko) 2001-02-26
US6346541B1 (en) 2002-02-12
ATE249438T1 (de) 2003-09-15
PT984938E (pt) 2004-02-27
DK0984938T3 (da) 2004-01-12
NZ501071A (en) 2001-08-31
CA2292895A1 (en) 1998-12-03
AU7638698A (en) 1998-12-30
EP0984938A1 (en) 2000-03-15
RO120541B1 (ro) 2006-03-30
EP0984938B1 (en) 2003-09-10
CA2292895C (en) 2007-03-06
KR100496220B1 (ko) 2005-06-21
ES2206932T3 (es) 2004-05-16
JP2001526694A (ja) 2001-12-18
DE69818041T2 (de) 2004-07-08
CN1116283C (zh) 2003-07-30
PL190314B1 (pl) 2005-11-30
WO1998054144A1 (en) 1998-12-03
PL337030A1 (en) 2000-07-31
CZ9904234A3 (cs) 2001-02-14
RU2195453C2 (ru) 2002-12-27
DE69818041D1 (de) 2003-10-16

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