GB963287A - New steroid compounds and processes for their preparation - Google Patents
New steroid compounds and processes for their preparationInfo
- Publication number
- GB963287A GB963287A GB3724061A GB3724061A GB963287A GB 963287 A GB963287 A GB 963287A GB 3724061 A GB3724061 A GB 3724061A GB 3724061 A GB3724061 A GB 3724061A GB 963287 A GB963287 A GB 963287A
- Authority
- GB
- United Kingdom
- Prior art keywords
- norpregn
- ene
- methyl
- trione
- hydroxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
Abstract
The invention comprises 17a -hydroxy-16a -methyl -18- norpregn -4- ene-3, 11, 20-trione derivatives having the formula: <FORM:0963287/C1/1> where R represents a hydrogen atom or a group convertible to a hydrogen atom by simple hydrolysis and process for the preparation thereof by hydroxylating 17a -hydroxy-16a -methyl -18- norpregn -4- ene-3, 11, 20-trione so as to introduce a hydroxyl or esterified hydroxyl group thereinto. Said hydroxylation may be effected microbiologically e.g. with Colletotrichum lindemuthianum or chemically by iodinating 17a -hydroxy -16a - methyl-18-norpregn -4- ene-3, 11, 20-trione in the presence of calcium chloride and calcium oxide to yield the corresponding 17a -hydroxy -21- diiodo -16a - methyl -18- norpregn -4- ene-3, 11, 20-trione, treating the resulting 21-diiodo derivative with an acyloxylating agent appropriate to the ester which it is sought to form, to obtain the corresponding 21-acyloxy -17a - hydroxy -16a - methyl -18- norpregn -4- ene-3, 11, 20-trione, which is saponified to yield 17a 21-dihydroxy -16a - methyl -18- norpregn -4- ene-3, 11, 20-trione. Specifications 807,203, 877,227, 934,707, 963,288 and 963,289 are referred to.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR841707A FR1365265A (en) | 1960-10-20 | 1960-10-20 | New cortisone compound and method of preparation |
Publications (1)
Publication Number | Publication Date |
---|---|
GB963287A true GB963287A (en) | 1964-07-08 |
Family
ID=8741143
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB4713163A Expired GB963289A (en) | 1960-10-20 | 1961-10-17 | New steroid compounds and processes for their preparation |
GB3724061A Expired GB963287A (en) | 1960-10-20 | 1961-10-17 | New steroid compounds and processes for their preparation |
GB4713063A Expired GB963288A (en) | 1960-10-20 | 1961-10-17 | New steroid compounds and processes for their preparation |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB4713163A Expired GB963289A (en) | 1960-10-20 | 1961-10-17 | New steroid compounds and processes for their preparation |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB4713063A Expired GB963288A (en) | 1960-10-20 | 1961-10-17 | New steroid compounds and processes for their preparation |
Country Status (3)
Country | Link |
---|---|
CH (1) | CH400147A (en) |
FR (1) | FR1365265A (en) |
GB (3) | GB963289A (en) |
-
1960
- 1960-10-20 FR FR841707A patent/FR1365265A/en not_active Expired
-
1961
- 1961-10-17 GB GB4713163A patent/GB963289A/en not_active Expired
- 1961-10-17 CH CH1199061A patent/CH400147A/en unknown
- 1961-10-17 GB GB3724061A patent/GB963287A/en not_active Expired
- 1961-10-17 GB GB4713063A patent/GB963288A/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
GB963289A (en) | 1964-07-08 |
CH400147A (en) | 1965-10-15 |
GB963288A (en) | 1964-07-08 |
FR1365265A (en) | 1964-07-03 |
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