GB958132A - Animal and plant therapeutic compositions - Google Patents
Animal and plant therapeutic compositionsInfo
- Publication number
- GB958132A GB958132A GB292061A GB292061A GB958132A GB 958132 A GB958132 A GB 958132A GB 292061 A GB292061 A GB 292061A GB 292061 A GB292061 A GB 292061A GB 958132 A GB958132 A GB 958132A
- Authority
- GB
- United Kingdom
- Prior art keywords
- positions
- substituents
- alkyl
- phenanthroline
- carbon atoms
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000000203 mixture Substances 0.000 title abstract 3
- 230000001225 therapeutic effect Effects 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 7
- 125000004432 carbon atom Chemical group C* 0.000 abstract 6
- DGEZNRSVGBDHLK-UHFFFAOYSA-N [1,10]phenanthroline Chemical compound C1=CN=C2C3=NC=CC=C3C=CC2=C1 DGEZNRSVGBDHLK-UHFFFAOYSA-N 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 3
- 239000002184 metal Substances 0.000 abstract 3
- 150000007524 organic acids Chemical class 0.000 abstract 3
- 125000001424 substituent group Chemical group 0.000 abstract 3
- 150000001450 anions Chemical class 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 150000007522 mineralic acids Chemical class 0.000 abstract 2
- -1 nose Substances 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 239000000243 solution Substances 0.000 abstract 2
- 238000006467 substitution reaction Methods 0.000 abstract 2
- 125000003944 tolyl group Chemical group 0.000 abstract 2
- 125000005023 xylyl group Chemical group 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 150000005045 1,10-phenanthrolines Chemical class 0.000 abstract 1
- SLRMQYXOBQWXCR-UHFFFAOYSA-N 2154-56-5 Chemical group [CH2]C1=CC=CC=C1 SLRMQYXOBQWXCR-UHFFFAOYSA-N 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 229930182555 Penicillin Natural products 0.000 abstract 1
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000011149 active material Substances 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 239000007900 aqueous suspension Substances 0.000 abstract 1
- 239000006071 cream Substances 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 239000003221 ear drop Substances 0.000 abstract 1
- 229940047652 ear drops Drugs 0.000 abstract 1
- 239000003889 eye drop Substances 0.000 abstract 1
- 229940012356 eye drops Drugs 0.000 abstract 1
- 230000000855 fungicidal effect Effects 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 239000006210 lotion Substances 0.000 abstract 1
- 239000007937 lozenge Substances 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 229940100662 nasal drops Drugs 0.000 abstract 1
- 239000002674 ointment Substances 0.000 abstract 1
- 235000005985 organic acids Nutrition 0.000 abstract 1
- 230000003647 oxidation Effects 0.000 abstract 1
- 238000007254 oxidation reaction Methods 0.000 abstract 1
- 229940049954 penicillin Drugs 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000843 powder Substances 0.000 abstract 1
- 150000003222 pyridines Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000000829 suppository Substances 0.000 abstract 1
- 239000003826 tablet Substances 0.000 abstract 1
- 230000003253 viricidal effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
- C07D213/22—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom containing two or more pyridine rings directly linked together, e.g. bipyridyl
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
- C07F13/005—Compounds without a metal-carbon linkage
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
- C07F15/0046—Ruthenium compounds
- C07F15/0053—Ruthenium compounds without a metal-carbon linkage
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/02—Iron compounds
- C07F15/025—Iron compounds without a metal-carbon linkage
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/04—Nickel compounds
- C07F15/045—Nickel compounds without a metal-carbon linkage
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/06—Cobalt compounds
- C07F15/065—Cobalt compounds without a metal-carbon linkage
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F19/00—Metal compounds according to more than one of main groups C07F1/00 - C07F17/00
- C07F19/005—Metal compounds according to more than one of main groups C07F1/00 - C07F17/00 without metal-C linkages
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Pharmaceutical, veterinary and agricultural fungicidal and virocidal compositions comprise a carrier and a 1,10-phenanthroline or 2,21-bipyridine derivative selected from the following classes of compounds:- Class 1. Substituted 1,10-phenanthroline and 2,21-bipyridine and their acid addition salts with inorganic and strong organic acids, the 1 : 10-phenanthroline compounds having from one to six substituents selected from alkyl, phenyl, tolyl and xylyl groups in the 2-, 3-, 4-, 5-, 6-, 7-, 8- and 9-positions and the 2,21-bipyridine compounds having substituents of the same kind in from one to four of the 4-, 5-, 6-, 41-, 51- and 61-positions, in the case of the 1,10-phenanthroline compounds substitution being in from one to six of the specified positions with alkyl groups or in one or two positions with the aromatic groups, such alkyl mono-and di-substituents totalling from two to fourteen carbon atoms and where di-substitution by alkyl groups involves the 3- and 4- or 7- and 8-positions, the alkyl groups may be joined to form, together with the nuclear carbon atoms to which they are attached, a 5-membered or 6-membered cycloalkane ring system, such alkyl tri-, tetra-, penta- and hexa-substituents totalling from 3 to 14, 4 to 14, 5 to 14 and 6 to 14 carbon atoms respectively and such phenyl, tolyl and xylyl mono- or di-substituents totalling from 6-16 carbon atoms, and, in the case of the 2,21-bipyridine compounds substituted by alkyl groups in from one to four positions or in one or two of the 5- and 51-positions with the aryl groups, the alkyl substituents total from 4 to 10 carbon atoms and the aryl substituents total from 6 to 16 carbon atoms. Class 2. Mono-N-alkylated substituted 1 : 10-phenanthroline and 2,21-bipyridine compounds represented by the formula (BR) + X-wherein B represents a base identified under Class 1 above, R represents a C1-6 alkyl or benzyl radical and X represents the anion of an inorganic or organic acid and: Class 3. Metal complexes of the formul (MB3)Xn and (MB2)Xn wherein M represents a metal selected from Fe++, Zn++, Mn++, Co++, Co+++, Cu++, Ni++, Ru++, Os++, Pt++, Pd++, Rh+++ and Ir+++, B represents a ligand provided by a base identified under Class 1 above except that the substituents are limited to the 3-, 4-, 5-, 6-, 7- and 8-positions on the phenanthroline nucleous and to the 4-, 5-, 41- and 51-positions on the pyridine nucleus, X represents the anion of an organic or inorganic acid and n is an integer determined by the oxidation state of the metal. Numerous specific examples of active compounds are disclosed. p The compositions may be in conventional forms, e.g. solutions, creams, lotions, nose, eye or ear drops, pessaries, suppositories, tablets or lozenges for pharmaceutical use, aqueous suspensions and solutions, ointments and drenches for veterinary use and dispersable powders and solutions for agricultural use. Veterinary and pharmaceutical compositions may also comprise materials which assist or enhance the action of the active materials, e.g. penicillin and tissue-penetrating enzymes. Specifications 956,241 and 956,848 are referred to.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU5684860 | 1960-01-26 | ||
AU56845/60A AU251506B2 (en) | 1960-01-26 | Animal and plant therapeutic compositions |
Publications (1)
Publication Number | Publication Date |
---|---|
GB958132A true GB958132A (en) | 1964-05-13 |
Family
ID=25631463
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB292061A Expired GB958132A (en) | 1960-01-26 | 1961-01-25 | Animal and plant therapeutic compositions |
Country Status (4)
Country | Link |
---|---|
BE (1) | BE617990A (en) |
CH (1) | CH452272A (en) |
GB (1) | GB958132A (en) |
NL (1) | NL260511A (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5200427A (en) * | 1984-07-27 | 1993-04-06 | The Board Of Trustees Of The Univ. Of Illinois | Porphyric insecticides |
NZ227505A (en) * | 1988-01-13 | 1992-02-25 | Univ Illinois | Insecticidal composition comprising delta-ala or inducers and enhancers thereof |
-
0
- BE BE617990D patent/BE617990A/xx unknown
- NL NL260511D patent/NL260511A/xx unknown
-
1961
- 1961-01-25 GB GB292061A patent/GB958132A/en not_active Expired
- 1961-01-26 CH CH90961A patent/CH452272A/en unknown
Also Published As
Publication number | Publication date |
---|---|
BE617990A (en) | |
NL260511A (en) | |
CH452272A (en) | 1968-05-31 |
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