GB956241A - New metal complexes of 1,10-phenanthrolines or bipyridines - Google Patents

New metal complexes of 1,10-phenanthrolines or bipyridines

Info

Publication number
GB956241A
GB956241A GB291961A GB291961A GB956241A GB 956241 A GB956241 A GB 956241A GB 291961 A GB291961 A GB 291961A GB 291961 A GB291961 A GB 291961A GB 956241 A GB956241 A GB 956241A
Authority
GB
United Kingdom
Prior art keywords
substituents
carbon atoms
alkyl
positions
totalling
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB291961A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Australian National University
Original Assignee
Australian National University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AU56846/60A external-priority patent/AU251889B2/en
Application filed by Australian National University filed Critical Australian National University
Publication of GB956241A publication Critical patent/GB956241A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
    • C07D213/22—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom containing two or more pyridine rings directly linked together, e.g. bipyridyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

The invention comprises metal complexes (M Chel3)Xn or (M Chel2)Xn wherein M represents a manganese (II) cobalt (II or III) copper (II), nickel (II), ruthenium (II), osmium (II), platinum (II), palladium (II), rhodium (III) and iridium (III); Chel represents a ligand provided by a substituted 1,10-phenanthroline or 2,21-bipyridine, the substituted 1,10-phenanthroline having substituents or a mixture of substituents selected from alkyl, phenyl, tolyl, and xylyl in one to six of the 3-, 4-, 5-, 6-, 7-, and 8-positions and the 2.21-bipyridine having similar substituents in one to four of the 4-, 5-, 41-, 51-positions, in the case of the phenanthroline the substitution being in one to six of the specified positions with the alkyl group or in one or two of the specified positions with the phenyl, totyl and xylyl groups, such alkyl mono-, di- and tetra-substituents totalling from four to fourteen carbon atoms and where disubstitution involves the 3-, 4-, and 7-, 8-positions either pair of carbon atoms may form part of 5-or 6-membered cycloalkane ring systems, such alkyl tri-substituents totalling from three to fourteen carbon atoms, such alkyl penta substituents totalling from five to fourteen carbon atoms such hexa-substituents totalling from six to fourteen carbon atoms and such phenyl, tolyl and xylyl mono- and disubstituents totalling from six to sixteen carbon atoms, and in the case of bipyridines the substitution being in one to four of the specified positions with the alkyl group or in one or two of the 5- and 51-positions with the phenyl, tolyl, and xylyl groups such alkyl substituents totalling from four to ten carbon atoms and such phenyl, tolyl and xylyl substituents from six to sixteen carbon atoms; X represents the anion of an organic or inorganic acid; and n an integer determined by the oxidation state of the metal and the preparation thereof by reacting together on a liquid medium a salt of the metal M with a substituted 1,10-phenanthroline or substituted 2,21-bipyridine. Where M is cobalt (III) the corresponding complex derived from cobalt (II), is oxidised in a further step and where M is ruthenium (II) or osmium (II) the phenanthroline or bipyridine is reacted under reducing conditions with a salt Z2(MX6) where Z is ammonium or an alkali metal or alkaline earth metal, M metal in valency state III or IV and X a halogen atom, a mixture of halogen atoms and hydroxyl groups or of halogen atoms and water molecules, there being at least four halogen atoms in the mixtures of X. Therapeutic compositions comprise the metal complexes of the invention together with a diluent or carrier. Compositions may be formulated as saline solutions, creams, lotions, drops, pessaries, suppositories, tablets or lozenges for treatment of bacterial infections in humans; in carriers such as a paraffin and wax base for treatment of bovine mastitis or as solutions or suspensions useful as a drench for use in veterinary treatments; or as solutions, suspensions, emulsions, concentrates and water dispersible powders for use as plant fungicides or virocides.
GB291961A 1960-01-26 1961-01-25 New metal complexes of 1,10-phenanthrolines or bipyridines Expired GB956241A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AU56846/60A AU251889B2 (en) 1960-01-25 New metal complexes with homogeneous ligands, and their preparation
AU8684860 1960-01-26
AU56847/60A AU251582B2 (en) 1960-01-26 New metal complexes with heterogeneous ligands, and their preparation

Publications (1)

Publication Number Publication Date
GB956241A true GB956241A (en) 1964-04-22

Family

ID=27155104

Family Applications (1)

Application Number Title Priority Date Filing Date
GB291961A Expired GB956241A (en) 1960-01-26 1961-01-25 New metal complexes of 1,10-phenanthrolines or bipyridines

Country Status (1)

Country Link
GB (1) GB956241A (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4269834A (en) * 1977-06-17 1981-05-26 Nauta Wijbe T Copper complexes of isoquinazolines
WO1990005732A1 (en) * 1988-11-07 1990-05-31 The Trustees Of Columbia University In The City Ofnew York Mixed ligand complexes and uses thereof as binding agents and probres to dna
US5171853A (en) * 1991-08-05 1992-12-15 North Carolina State University Process of cleaving nucleic acids with oxoruthenium(IV) complexes
WO1997001559A1 (en) * 1995-06-29 1997-01-16 Procyte Corporation Zinc(ii) complexes and methods related thereto

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4269834A (en) * 1977-06-17 1981-05-26 Nauta Wijbe T Copper complexes of isoquinazolines
WO1990005732A1 (en) * 1988-11-07 1990-05-31 The Trustees Of Columbia University In The City Ofnew York Mixed ligand complexes and uses thereof as binding agents and probres to dna
US5171853A (en) * 1991-08-05 1992-12-15 North Carolina State University Process of cleaving nucleic acids with oxoruthenium(IV) complexes
WO1997001559A1 (en) * 1995-06-29 1997-01-16 Procyte Corporation Zinc(ii) complexes and methods related thereto

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