GB943957A - New steroid compounds and processes for the production thereof - Google Patents

New steroid compounds and processes for the production thereof

Info

Publication number
GB943957A
GB943957A GB4519162A GB4519162A GB943957A GB 943957 A GB943957 A GB 943957A GB 4519162 A GB4519162 A GB 4519162A GB 4519162 A GB4519162 A GB 4519162A GB 943957 A GB943957 A GB 943957A
Authority
GB
United Kingdom
Prior art keywords
methyl
together represent
dione
oxygen atom
processes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB4519162A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Publication of GB943957A publication Critical patent/GB943957A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)

Abstract

The invention comprises 17-methyl-18-nor-Dhomoetiocholane-3, 11-dione derivatives having the formula: <FORM:0943957/C2/1> where X and Y together represent a double bond, Z represents a hydrogen atom and R represents either the oxygen atom of a keto group or cyclic ketal thereof; or X represents a hydrogen atom and either Y and Z together represent a double bond and R represents either the oxygen atom of a ketone group or a cyclic ketal group thereof or alternatively Y and Z together represent an ozonide linkage between the 16- and 17-position and R is the oxygen atom of a keto group and processes for the production thereof by reacting a 17-halogeno-17-methyl-18-nor-D-homoetiocholane-3, 11-dione with a lithium halide/lithium carbonate couple in an inert solvent thereby to form a mixture of the D 16 and D 17 isomers of 17-methyl-18-nor-D-homoetiocholene-3, 11-dione and if desired reacting this compound with ozone to form the 16, 17ozonide thereof. Separation of the D 16 and D 17 isomers may be effected by ketalising the mixture, separating the ketals thus obtained and recovering the desired compound from the appropriate ketal. Specifications 832,244 and 943,956 also are referred to.
GB4519162A 1959-12-24 1960-12-22 New steroid compounds and processes for the production thereof Expired GB943957A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR814116A FR1280589A (en) 1959-12-24 1959-12-24 New 18-nor pregnanic derivative and method of preparation

Publications (1)

Publication Number Publication Date
GB943957A true GB943957A (en) 1963-12-11

Family

ID=8723042

Family Applications (4)

Application Number Title Priority Date Filing Date
GB4519062A Expired GB943956A (en) 1959-12-24 1960-12-22 Novel steroid compounds and processes for their preparation
GB4418360A Expired GB943952A (en) 1959-12-24 1960-12-22 A new steroid compound and its formation
GB4519162A Expired GB943957A (en) 1959-12-24 1960-12-22 New steroid compounds and processes for the production thereof
GB4519262A Expired GB943958A (en) 1959-12-24 1960-12-22 Novel steroid compounds and processes for their preparation

Family Applications Before (2)

Application Number Title Priority Date Filing Date
GB4519062A Expired GB943956A (en) 1959-12-24 1960-12-22 Novel steroid compounds and processes for their preparation
GB4418360A Expired GB943952A (en) 1959-12-24 1960-12-22 A new steroid compound and its formation

Family Applications After (1)

Application Number Title Priority Date Filing Date
GB4519262A Expired GB943958A (en) 1959-12-24 1960-12-22 Novel steroid compounds and processes for their preparation

Country Status (3)

Country Link
CH (1) CH394189A (en)
FR (1) FR1280589A (en)
GB (4) GB943956A (en)

Also Published As

Publication number Publication date
GB943952A (en) 1963-12-11
FR1280589A (en) 1962-01-08
GB943956A (en) 1963-12-11
CH394189A (en) 1965-06-30
GB943958A (en) 1963-12-11

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