GB938712A - Farnesyl acetic esters - Google Patents
Farnesyl acetic estersInfo
- Publication number
- GB938712A GB938712A GB18812/61A GB1881261A GB938712A GB 938712 A GB938712 A GB 938712A GB 18812/61 A GB18812/61 A GB 18812/61A GB 1881261 A GB1881261 A GB 1881261A GB 938712 A GB938712 A GB 938712A
- Authority
- GB
- United Kingdom
- Prior art keywords
- formula
- coor
- alcohol
- compound
- ester
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 125000004030 farnesyl group Chemical group [H]C([*])([H])C([H])=C(C([H])([H])[H])C([H])([H])C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H] 0.000 title abstract 2
- 235000019439 ethyl acetate Nutrition 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 4
- 150000008064 anhydrides Chemical class 0.000 abstract 2
- 150000002148 esters Chemical class 0.000 abstract 2
- 150000004820 halides Chemical class 0.000 abstract 2
- 230000007062 hydrolysis Effects 0.000 abstract 2
- 238000006460 hydrolysis reaction Methods 0.000 abstract 2
- FYSNRJHAOHDILO-UHFFFAOYSA-N thionyl chloride Chemical compound ClS(Cl)=O FYSNRJHAOHDILO-UHFFFAOYSA-N 0.000 abstract 2
- VOKDWPMRYSKGTB-NCZFFCEISA-N (4e,8e)-5,9,13-trimethyltetradeca-4,8,12-trienoic acid Chemical class CC(C)=CCC\C(C)=C\CC\C(C)=C\CCC(O)=O VOKDWPMRYSKGTB-NCZFFCEISA-N 0.000 abstract 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 abstract 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 abstract 1
- 208000025865 Ulcer Diseases 0.000 abstract 1
- WETWJCDKMRHUPV-UHFFFAOYSA-N acetyl chloride Chemical compound CC(Cl)=O WETWJCDKMRHUPV-UHFFFAOYSA-N 0.000 abstract 1
- 239000012346 acetyl chloride Substances 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- JXLHNMVSKXFWAO-UHFFFAOYSA-N azane;7-fluoro-2,1,3-benzoxadiazole-4-sulfonic acid Chemical compound N.OS(=O)(=O)C1=CC=C(F)C2=NON=C12 JXLHNMVSKXFWAO-UHFFFAOYSA-N 0.000 abstract 1
- 239000002775 capsule Substances 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 238000006114 decarboxylation reaction Methods 0.000 abstract 1
- 150000005690 diesters Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- CCGKOQOJPYTBIH-UHFFFAOYSA-N ethenone Chemical compound C=C=O CCGKOQOJPYTBIH-UHFFFAOYSA-N 0.000 abstract 1
- 230000002496 gastric effect Effects 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 125000004415 heterocyclylalkyl group Chemical group 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 210000004877 mucosa Anatomy 0.000 abstract 1
- 239000002674 ointment Substances 0.000 abstract 1
- 125000000962 organic group Chemical group 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- GGCZERPQGJTIQP-UHFFFAOYSA-N sodium;9,10-dioxoanthracene-2-sulfonic acid Chemical compound [Na+].C1=CC=C2C(=O)C3=CC(S(=O)(=O)O)=CC=C3C(=O)C2=C1 GGCZERPQGJTIQP-UHFFFAOYSA-N 0.000 abstract 1
- 229910021653 sulphate ion Inorganic materials 0.000 abstract 1
- 239000000829 suppository Substances 0.000 abstract 1
- 235000020357 syrup Nutrition 0.000 abstract 1
- 239000006188 syrup Substances 0.000 abstract 1
- 230000000699 topical effect Effects 0.000 abstract 1
- 231100000397 ulcer Toxicity 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/40—Radicals substituted by oxygen atoms
- C07D307/42—Singly bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
- C07C57/03—Monocarboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/02—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen
- C07C69/22—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen having three or more carbon atoms in the acid moiety
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/52—Esters of acyclic unsaturated carboxylic acids having the esterified carboxyl group bound to an acyclic carbon atom
- C07C69/587—Monocarboxylic acid esters having at least two carbon-to-carbon double bonds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Priority Applications (22)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB18812/61A GB938712A (en) | 1961-05-24 | 1961-05-24 | Farnesyl acetic esters |
| FI90662A FI40163C (fi) | 1961-05-24 | 1962-05-04 | Förfarande för framställning av farnesylättiksyraestrar |
| US193876A US3154570A (en) | 1961-05-24 | 1962-05-10 | Esters of farnesyl acetic acid |
| DE19621468055 DE1468055A1 (de) | 1961-05-24 | 1962-05-11 | Verfahren zur Herstellung von Farnesylestern |
| DE19621793591 DE1793591B2 (de) | 1961-05-24 | 1962-05-11 | Ester der farnesylessigsaeure |
| AT1003363A AT244317B (de) | 1961-05-24 | 1962-05-15 | Verfahren zur Herstellung von neuen Farnesylesigsäureestern |
| AT1003263A AT243773B (de) | 1961-05-24 | 1962-05-15 | Verfahren zur Herstellung von neuen Farnesylessigsäureestern |
| AT398262A AT240341B (de) | 1961-05-24 | 1962-05-15 | Verfahren zur Herstellung von neuen Farnesylessigsäureestern |
| DK221362AA DK114825B (da) | 1961-05-24 | 1962-05-16 | Fremgangsmåde til fremstilling af farnesyleddikesyreestere. |
| CH590862A CH420117A (de) | 1961-05-24 | 1962-05-16 | Verfahren zur Herstellung von Farnesylessigsäureestern |
| CH301066A CH416600A (de) | 1961-05-24 | 1962-05-16 | Verfahren zur Herstellung von Farnesylessigsäureestern |
| CH300966A CH416599A (de) | 1961-05-24 | 1962-05-16 | Verfahren zur Herstellung von Farnesylessigsäureestern |
| FR898375A FR1981M (fr) | 1961-05-24 | 1962-05-22 | Médicament anti-ulcéreux a base d'esters de l'acide farnésyl-acétique. |
| BE617994A BE617994A (fr) | 1961-05-24 | 1962-05-23 | Dérivés de l'acide farnésyl-acétique, leur préparation et leur utilisation |
| SE5796/62A SE305864B (enrdf_load_stackoverflow) | 1961-05-24 | 1962-05-23 | |
| SE6865/64A SE301313B (sv) | 1961-05-24 | 1964-06-05 | Sätt att framställa terapeutiskt verksamma farnesyl-ättiksyraestrar |
| SE6864/64A SE301475B (sv) | 1961-05-24 | 1964-06-05 | Sätt att framställa terapeutiskt verksamma farnesyl-ättiksyraestrar |
| DK561764AA DK115254B (da) | 1961-05-24 | 1964-11-13 | Fremgangsmåde til fremstilling af farnesyleddikesyreestere. |
| DK561664AA DK115469B (da) | 1961-05-24 | 1964-11-13 | Fremgangsmåde til fremstilling af farnesyleddikesyreestere. |
| FI2229/66A FI40284B (enrdf_load_stackoverflow) | 1961-05-24 | 1966-08-25 | |
| FI2230/66A FI40285B (enrdf_load_stackoverflow) | 1961-05-24 | 1966-08-25 | |
| IN2772/CAL/1973A IN138556B (enrdf_load_stackoverflow) | 1961-05-24 | 1973-12-20 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB18812/61A GB938712A (en) | 1961-05-24 | 1961-05-24 | Farnesyl acetic esters |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB938712A true GB938712A (en) | 1963-10-02 |
Family
ID=10118834
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB18812/61A Expired GB938712A (en) | 1961-05-24 | 1961-05-24 | Farnesyl acetic esters |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US3154570A (enrdf_load_stackoverflow) |
| AT (3) | AT244317B (enrdf_load_stackoverflow) |
| BE (1) | BE617994A (enrdf_load_stackoverflow) |
| CH (3) | CH416599A (enrdf_load_stackoverflow) |
| DE (2) | DE1468055A1 (enrdf_load_stackoverflow) |
| DK (3) | DK114825B (enrdf_load_stackoverflow) |
| FI (3) | FI40163C (enrdf_load_stackoverflow) |
| FR (1) | FR1981M (enrdf_load_stackoverflow) |
| GB (1) | GB938712A (enrdf_load_stackoverflow) |
| IN (1) | IN138556B (enrdf_load_stackoverflow) |
| SE (3) | SE305864B (enrdf_load_stackoverflow) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4900749A (en) * | 1985-03-15 | 1990-02-13 | Shionogi & Co., Ltd. | Isoprenoidamine compounds useful as antiulcer agents |
| US5298655A (en) * | 1991-09-27 | 1994-03-29 | Merck & Co., Inc. | Farnesyl pyrophosphate analogs |
| US5574025A (en) * | 1994-10-26 | 1996-11-12 | Merck & Co., Inc. | Inhibitors of prenyl-protein transferases |
| CN105753696A (zh) * | 2016-03-04 | 2016-07-13 | 湖南晶天科技实业有限公司 | 一种香芹酚酯、饲料添加剂和饲料 |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2245607B1 (enrdf_load_stackoverflow) * | 1973-04-18 | 1979-04-20 | Kuraray Co | |
| JPS5623415B2 (enrdf_load_stackoverflow) * | 1973-07-13 | 1981-05-30 | ||
| US3928403A (en) * | 1974-07-10 | 1975-12-23 | Kuraray Co | Process for preparing farnesyl acetic acid esters and 2-substituted-products thereof |
| US4028385A (en) * | 1974-09-02 | 1977-06-07 | Kuraray Co., Ltd. | Process for preparing stereospecific farnesylacetic acid and ester thereof |
| JPS5855129B2 (ja) * | 1974-11-21 | 1983-12-08 | 株式会社クラレ | ２−置換または無置換のゲラニル酢酸エステル類の製造方法 |
| JPS53145922A (en) * | 1977-05-26 | 1978-12-19 | Eisai Co Ltd | Remedy for peptic ulcer containing prenyl ketone compound |
| US4738801A (en) * | 1978-03-23 | 1988-04-19 | Nisshin Flour Milling Co., Ltd. | Antiulcer compounds |
| FR2420523A1 (fr) * | 1978-03-23 | 1979-10-19 | Nisshin Flour Milling Co | Nouveaux derives acides et esters et leur application comme agents antiulcere |
| US4483871A (en) * | 1978-03-23 | 1984-11-20 | Nisshin Flour Milling Co., Ltd. | Antiulcer compounds |
| US4642314A (en) * | 1978-03-23 | 1987-02-10 | Nisshin Flour Milling Co., Ltd. | Antiulcer compounds |
| JPS5573642A (en) * | 1978-11-28 | 1980-06-03 | Kuraray Co Ltd | Farnesyl-acetic ester derivative |
| JPS57106644A (en) * | 1980-12-20 | 1982-07-02 | Kotobuki Seiyaku Kk | Farnesence derivative, mucosa stabilizer comprising it as active ingredient, and its preparation |
| WO1999067809A1 (en) * | 1998-06-24 | 1999-12-29 | Merck & Co., Inc. | Compositions and methods for inhibiting bone resorption |
| WO2014207235A1 (en) * | 2013-06-28 | 2014-12-31 | Castrol Limited | Lubricating compositions containing isoprene based components |
-
1961
- 1961-05-24 GB GB18812/61A patent/GB938712A/en not_active Expired
-
1962
- 1962-05-04 FI FI90662A patent/FI40163C/fi active
- 1962-05-10 US US193876A patent/US3154570A/en not_active Expired - Lifetime
- 1962-05-11 DE DE19621468055 patent/DE1468055A1/de active Pending
- 1962-05-11 DE DE19621793591 patent/DE1793591B2/de active Granted
- 1962-05-15 AT AT1003363A patent/AT244317B/de active
- 1962-05-15 AT AT1003263A patent/AT243773B/de active
- 1962-05-15 AT AT398262A patent/AT240341B/de active
- 1962-05-16 CH CH300966A patent/CH416599A/de unknown
- 1962-05-16 CH CH590862A patent/CH420117A/de unknown
- 1962-05-16 DK DK221362AA patent/DK114825B/da unknown
- 1962-05-16 CH CH301066A patent/CH416600A/de unknown
- 1962-05-22 FR FR898375A patent/FR1981M/fr active Active
- 1962-05-23 BE BE617994A patent/BE617994A/fr unknown
- 1962-05-23 SE SE5796/62A patent/SE305864B/xx unknown
-
1964
- 1964-06-05 SE SE6865/64A patent/SE301313B/xx unknown
- 1964-06-05 SE SE6864/64A patent/SE301475B/xx unknown
- 1964-11-13 DK DK561664AA patent/DK115469B/da unknown
- 1964-11-13 DK DK561764AA patent/DK115254B/da unknown
-
1966
- 1966-08-25 FI FI2229/66A patent/FI40284B/fi active
- 1966-08-25 FI FI2230/66A patent/FI40285B/fi active
-
1973
- 1973-12-20 IN IN2772/CAL/1973A patent/IN138556B/en unknown
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4900749A (en) * | 1985-03-15 | 1990-02-13 | Shionogi & Co., Ltd. | Isoprenoidamine compounds useful as antiulcer agents |
| US4977170A (en) * | 1985-03-15 | 1990-12-11 | Shionogi & Co., Ltd. | Isoprenoidamine compounds which are useful antiulcer agents |
| US5298655A (en) * | 1991-09-27 | 1994-03-29 | Merck & Co., Inc. | Farnesyl pyrophosphate analogs |
| US5574025A (en) * | 1994-10-26 | 1996-11-12 | Merck & Co., Inc. | Inhibitors of prenyl-protein transferases |
| CN105753696A (zh) * | 2016-03-04 | 2016-07-13 | 湖南晶天科技实业有限公司 | 一种香芹酚酯、饲料添加剂和饲料 |
| CN105753696B (zh) * | 2016-03-04 | 2019-03-08 | 湖南晶天科技实业有限公司 | 一种香芹酚酯、饲料添加剂和饲料 |
Also Published As
| Publication number | Publication date |
|---|---|
| DE1793591A1 (de) | 1971-03-18 |
| AT243773B (de) | 1965-11-25 |
| DK115469B (da) | 1969-10-13 |
| FI40163B (enrdf_load_stackoverflow) | 1968-07-31 |
| DE1793591C3 (enrdf_load_stackoverflow) | 1974-03-28 |
| DE1793591B2 (de) | 1973-08-23 |
| CH420117A (de) | 1966-09-15 |
| BE617994A (fr) | 1962-09-17 |
| FR1981M (fr) | 1963-08-26 |
| DK114825B (da) | 1969-08-11 |
| FI40163C (fi) | 1968-11-11 |
| DK115254B (da) | 1969-09-22 |
| CH416600A (de) | 1966-07-15 |
| IN138556B (enrdf_load_stackoverflow) | 1976-02-21 |
| CH416599A (de) | 1966-07-15 |
| SE305864B (enrdf_load_stackoverflow) | 1968-11-11 |
| DE1468055A1 (de) | 1969-04-03 |
| AT244317B (de) | 1965-12-27 |
| SE301313B (sv) | 1968-06-04 |
| FI40284B (enrdf_load_stackoverflow) | 1968-09-02 |
| SE301475B (sv) | 1968-06-10 |
| AT240341B (de) | 1965-05-25 |
| US3154570A (en) | 1964-10-27 |
| FI40285B (enrdf_load_stackoverflow) | 1968-09-02 |
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