GB935352A - Production of 2-aminopyrimidine - Google Patents

Production of 2-aminopyrimidine

Info

Publication number
GB935352A
GB935352A GB1502/62A GB150262A GB935352A GB 935352 A GB935352 A GB 935352A GB 1502/62 A GB1502/62 A GB 1502/62A GB 150262 A GB150262 A GB 150262A GB 935352 A GB935352 A GB 935352A
Authority
GB
United Kingdom
Prior art keywords
guanidine
proparglyaldehyde
salt
hydrogen chloride
temperatures
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1502/62A
Inventor
Heinrich Pasedach
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BASF SE
Original Assignee
BASF SE
Badische Anilin and Sodafabrik AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BASF SE, Badische Anilin and Sodafabrik AG filed Critical BASF SE
Publication of GB935352A publication Critical patent/GB935352A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A process for the production of 2-amino-pyrimidine comprises reacting proparglyaldehyde at temperatures of -10 DEG C. to +100 DEG C., preferably 0 DEG C. to 40 DEG C., with concentrated hydrochloric acid, the hydrogen chloride content of which it at least 20% by weight and is equal to at least 1 mole equivalent, preferably 3 to 6 mole equivalent, with reference to the amount of proparglyaldehyde, while agitating vigorously, the reaction mixture being allowed to react with guanidine or a salt of guanidine at temperatures between -10 DEG C. and +100 DEG C. The reaction with guanidine or a salt of guanidine is preferably carried out in the presence of a further condensing agent such as hydrobromic acid, sulphuric acid or additional hydrogen chloride. The proparglyaldehyde and hydrogen chloride initially react to produce an adduct which is not b -chloroacrolein. Examples are given, guanidine hydrochloride being used as the guanidine salt. Specifications 765,506 and 807,247 are referred to.
GB1502/62A 1961-01-18 1962-01-16 Production of 2-aminopyrimidine Expired GB935352A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DEB60877A DE1193951B (en) 1961-01-18 1961-01-18 Process for the preparation of 2-amino-pyrimidine

Publications (1)

Publication Number Publication Date
GB935352A true GB935352A (en) 1963-08-28

Family

ID=6973005

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1502/62A Expired GB935352A (en) 1961-01-18 1962-01-16 Production of 2-aminopyrimidine

Country Status (5)

Country Link
BE (1) BE612751A (en)
CH (1) CH410964A (en)
DE (1) DE1193951B (en)
DK (1) DK107939C (en)
GB (1) GB935352A (en)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB860423A (en) * 1958-10-25 1961-02-08 Basf Ag Production of compounds of the pyrimidine series

Also Published As

Publication number Publication date
BE612751A (en) 1962-07-17
DE1193951B (en) 1965-06-03
DK107939C (en) 1967-07-24
CH410964A (en) 1966-04-15

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