GB915304A - Pyrrolo[2,3-d]pyrimidine derivatives - Google Patents
Pyrrolo[2,3-d]pyrimidine derivativesInfo
- Publication number
- GB915304A GB915304A GB32973/61A GB3297361A GB915304A GB 915304 A GB915304 A GB 915304A GB 32973/61 A GB32973/61 A GB 32973/61A GB 3297361 A GB3297361 A GB 3297361A GB 915304 A GB915304 A GB 915304A
- Authority
- GB
- United Kingdom
- Prior art keywords
- pyrrolo
- methyl
- pyrimidine derivatives
- diethoxyethyl
- hydroxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000004943 pyrrolo[2,3-d]pyrimidines Chemical class 0.000 title abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
- XHXFXVLFKHQFAL-UHFFFAOYSA-N phosphoryl trichloride Chemical compound ClP(Cl)(Cl)=O XHXFXVLFKHQFAL-UHFFFAOYSA-N 0.000 abstract 2
- 238000010992 reflux Methods 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- FBMZEITWVNHWJW-UHFFFAOYSA-N 1,7-dihydropyrrolo[2,3-d]pyrimidin-4-one Chemical class OC1=NC=NC2=C1C=CN2 FBMZEITWVNHWJW-UHFFFAOYSA-N 0.000 abstract 1
- ZFUQHMCXUYLASE-UHFFFAOYSA-N 2-methyl-1,7-dihydropyrrolo[2,3-d]pyrimidin-4-one Chemical compound N1C(C)=NC(=O)C2=C1NC=C2 ZFUQHMCXUYLASE-UHFFFAOYSA-N 0.000 abstract 1
- KAWSVQQRUYEZOY-UHFFFAOYSA-N 6-amino-5-(2,2-diethoxyethyl)-2-methyl-1h-pyrimidin-4-one Chemical compound CCOC(OCC)CC1=C(N)NC(C)=NC1=O KAWSVQQRUYEZOY-UHFFFAOYSA-N 0.000 abstract 1
- OQLZINXFSUDMHM-UHFFFAOYSA-N Acetamidine Chemical compound CC(N)=N OQLZINXFSUDMHM-UHFFFAOYSA-N 0.000 abstract 1
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- AHKACZDKUNMFBD-UHFFFAOYSA-N ethyl 2-cyano-4,4-diethoxybutanoate Chemical compound CCOC(OCC)CC(C#N)C(=O)OCC AHKACZDKUNMFBD-UHFFFAOYSA-N 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- -1 methyl halide Chemical class 0.000 abstract 1
- 230000001035 methylating effect Effects 0.000 abstract 1
- 235000011149 sulphuric acid Nutrition 0.000 abstract 1
- 239000001117 sulphuric acid Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US72110458A | 1958-03-13 | 1958-03-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB915304A true GB915304A (en) | 1963-01-09 |
Family
ID=24896553
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB32973/61A Expired GB915304A (en) | 1958-03-13 | 1959-03-09 | Pyrrolo[2,3-d]pyrimidine derivatives |
| GB8013/59A Expired GB915303A (en) | 1958-03-13 | 1959-03-09 | Pyrrolo[2,3-d]pyrimidine derivatives and the manufacture thereof |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB8013/59A Expired GB915303A (en) | 1958-03-13 | 1959-03-09 | Pyrrolo[2,3-d]pyrimidine derivatives and the manufacture thereof |
Country Status (3)
| Country | Link |
|---|---|
| ES (1) | ES247857A1 (cg-RX-API-DMAC7.html) |
| FR (1) | FR607M (cg-RX-API-DMAC7.html) |
| GB (2) | GB915304A (cg-RX-API-DMAC7.html) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3311628A (en) * | 1965-03-09 | 1967-03-28 | Bristol Myers Co | Derivatives of pyrrolo [2, 3-d] pyrimidine |
| US7687507B2 (en) | 1998-06-19 | 2010-03-30 | Pfizer Inc. | Pyrrolo[2,3-d]pyrimidine compounds |
| US8133899B2 (en) | 2008-08-20 | 2012-03-13 | Pfizer Inc. | Pyrrolo[2,3-d]pyrimidine compounds |
| US12202834B2 (en) | 2019-01-29 | 2025-01-21 | Vationpharma B.V. | Solid state forms of oclacitinib maleate |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH592668A5 (cg-RX-API-DMAC7.html) * | 1973-10-02 | 1977-10-31 | Delalande Sa | |
| ES2109796T3 (es) * | 1994-05-03 | 1998-01-16 | Ciba Geigy Ag | Derivados de pirrolopirimidilo con efecto antiproliferante. |
| HUP0103836A3 (en) * | 1998-06-02 | 2003-05-28 | Osi Pharmaceuticals Inc Uniond | Pyrrolo[2,3d]pyrimidine compositions and their use |
| US6878716B1 (en) | 1998-06-02 | 2005-04-12 | Osi Pharmaceuticals, Inc. | Compounds specific to adenosine A1 receptor and uses thereof |
| US6686366B1 (en) | 1998-06-02 | 2004-02-03 | Osi Pharmaceuticals, Inc. | Compounds specific to adenosine A3 receptor and uses thereof |
| PA8474101A1 (es) | 1998-06-19 | 2000-09-29 | Pfizer Prod Inc | Compuestos de pirrolo [2,3-d] pirimidina |
| US6680322B2 (en) | 1999-12-02 | 2004-01-20 | Osi Pharmaceuticals, Inc. | Compounds specific to adenosine A1 receptors and uses thereof |
| US6664252B2 (en) | 1999-12-02 | 2003-12-16 | Osi Pharmaceuticals, Inc. | 4-aminopyrrolo[2,3-d]pyrimidine compounds specific to adenosine A2a receptor and uses thereof |
| US7160890B2 (en) | 1999-12-02 | 2007-01-09 | Osi Pharmaceuticals, Inc. | Compounds specific to adenosine A3 receptor and uses thereof |
| OA12118A (en) | 1999-12-10 | 2006-05-04 | Pfizer Prod Inc | PyrroloÄ2,3-dÜpyrimidine compounds. |
| US6673802B2 (en) | 2000-12-01 | 2004-01-06 | Osi Pharmaceuticals, Inc. | Compounds specific to adenosine A3 receptor and uses thereof |
| US6680324B2 (en) | 2000-12-01 | 2004-01-20 | Osi Pharmaceuticals, Inc. | Compounds specific to adenosine A1 receptors and uses thereof |
| DE10148883A1 (de) * | 2001-10-04 | 2003-04-10 | Merck Patent Gmbh | Pyrimidinderivate |
| JP2005529062A (ja) | 2001-11-30 | 2005-09-29 | オーエスアイ・ファーマスーティカルズ・インコーポレーテッド | アデノシンａ１及びａ３受容体に特異的な化合物とその使用 |
| KR20040068317A (ko) | 2001-12-20 | 2004-07-30 | 오에스아이 파마슈티컬스, 인코포레이티드 | 피리미딘 ａ₂ｂ 선택성 길항 화합물, 그의 합성 방법 및용도 |
| DE60236458D1 (de) | 2001-12-20 | 2010-07-01 | Osi Pharm Inc | Pyrrolopyrimidin a2b selektive antagonistische verbindungen, deren synthese und verwendung |
| WO2004047843A1 (en) | 2002-11-26 | 2004-06-10 | Pfizer Products Inc. | Method of treatment of transplant rejection |
| WO2007084667A2 (en) * | 2006-01-19 | 2007-07-26 | Osi Pharmaceutical, Inc. | Fused heterobicyclic kinase inhibitors |
| WO2026050970A1 (zh) * | 2024-09-05 | 2026-03-12 | 甫康（上海）健康科技有限责任公司 | 一种用于吡咯并[2，3-d]嘧啶衍生物的制备方法和新颖中间体 |
-
1959
- 1959-03-09 GB GB32973/61A patent/GB915304A/en not_active Expired
- 1959-03-09 GB GB8013/59A patent/GB915303A/en not_active Expired
- 1959-04-12 ES ES0247857A patent/ES247857A1/es not_active Expired
-
1961
- 1961-08-31 FR FR837423A patent/FR607M/fr active Active
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3311628A (en) * | 1965-03-09 | 1967-03-28 | Bristol Myers Co | Derivatives of pyrrolo [2, 3-d] pyrimidine |
| US7687507B2 (en) | 1998-06-19 | 2010-03-30 | Pfizer Inc. | Pyrrolo[2,3-d]pyrimidine compounds |
| US8133899B2 (en) | 2008-08-20 | 2012-03-13 | Pfizer Inc. | Pyrrolo[2,3-d]pyrimidine compounds |
| US8987283B2 (en) | 2008-08-20 | 2015-03-24 | Zoetis Llc | Pyrrolo[2,3-D]pyrimidine compounds |
| US9161939B2 (en) | 2008-08-20 | 2015-10-20 | Zoetis Services Llc | Pyrrolo[2,3-d]pyrimidine compounds |
| US9271981B2 (en) | 2008-08-20 | 2016-03-01 | Zoetis Services Llc | Pyrrolo[2,3-D]pyrimidine compounds |
| US12202834B2 (en) | 2019-01-29 | 2025-01-21 | Vationpharma B.V. | Solid state forms of oclacitinib maleate |
Also Published As
| Publication number | Publication date |
|---|---|
| ES247857A1 (es) | 1959-08-16 |
| FR607M (cg-RX-API-DMAC7.html) | 1961-06-19 |
| GB915303A (en) | 1963-01-09 |
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