GB989048A - Pyrido[2,3-d]pyrimidines - Google Patents
Pyrido[2,3-d]pyrimidinesInfo
- Publication number
- GB989048A GB989048A GB2967663A GB2967663A GB989048A GB 989048 A GB989048 A GB 989048A GB 2967663 A GB2967663 A GB 2967663A GB 2967663 A GB2967663 A GB 2967663A GB 989048 A GB989048 A GB 989048A
- Authority
- GB
- United Kingdom
- Prior art keywords
- malonic acid
- methyl groups
- compounds
- reaction
- pyrido
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
The invention comprises compounds having in one tautomeric form the general formula <FORM:0989048/C2/1> and alkali metal salts thereof, wherein R6 represents a hydrogen atom or alkyl group of 1 to 6 carbon atoms and R1, R3 and R8 represent hydrogen atoms or methyl groups. The compounds are prepared by the reaction of a 4-aminouracil, which may have methyl groups in the 1 and/or 3 positions and/or on the amino nitrogen atom, with malonic acid or an alkyl substituted malonic acid in the presence of a condensing agent. Suitable condensing agents are acetic, propionic or butyric anhydrides, preferably acetic anhydride. The reaction takes place at room temperature but temperatures in the range 30 DEG to 100 DEG C. are preferred.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US21418762A | 1962-08-02 | 1962-08-02 | |
| US290205A US3139432A (en) | 1963-06-24 | 1963-06-24 | Pyrido [2, 3-d] pyrimidine-2, 4, 5, 7-tetraones |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB989048A true GB989048A (en) | 1965-04-14 |
Family
ID=26908757
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB2967663A Expired GB989048A (en) | 1962-08-02 | 1963-07-26 | Pyrido[2,3-d]pyrimidines |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB989048A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4808587A (en) * | 1986-04-16 | 1989-02-28 | Nippon Zoki Pharmaceutical Co., Ltd. | 5-substituted pyrido[2,3-d]pyrimidine-2,4-diones |
| US5776942A (en) * | 1994-06-17 | 1998-07-07 | Nippon Zoki Pharmaceutical Co., Ltd. | Bronchodilating pyrido 2,3-d!pyrimidine derivatives |
| US6242452B1 (en) | 1998-10-15 | 2001-06-05 | Nippon Zoki Pharmaceutical Co., Ltd. | 7-aminopyrido[2,3-D]pyrimidine derivatives |
| US6440978B2 (en) | 2000-04-13 | 2002-08-27 | Nippon Zoki Pharmaceutical Co., Ltd. | Therapeutic agent for dermatitis |
-
1963
- 1963-07-26 GB GB2967663A patent/GB989048A/en not_active Expired
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4808587A (en) * | 1986-04-16 | 1989-02-28 | Nippon Zoki Pharmaceutical Co., Ltd. | 5-substituted pyrido[2,3-d]pyrimidine-2,4-diones |
| US5776942A (en) * | 1994-06-17 | 1998-07-07 | Nippon Zoki Pharmaceutical Co., Ltd. | Bronchodilating pyrido 2,3-d!pyrimidine derivatives |
| US6242452B1 (en) | 1998-10-15 | 2001-06-05 | Nippon Zoki Pharmaceutical Co., Ltd. | 7-aminopyrido[2,3-D]pyrimidine derivatives |
| US6440978B2 (en) | 2000-04-13 | 2002-08-27 | Nippon Zoki Pharmaceutical Co., Ltd. | Therapeutic agent for dermatitis |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| GB1521092A (en) | 3-phenyl-5-substituted-4 (1h)-pyridones-(thiones) | |
| GB1055056A (en) | Benzo-cyclohepta-thiophene derivatives and method of producing them | |
| GB1079196A (en) | New 5-nitrofuryl and 5-nitrothienyl compounds | |
| GB989048A (en) | Pyrido[2,3-d]pyrimidines | |
| GB1111988A (en) | 2',3'-dideoxyriboside-2',3'-olefins | |
| ES432497A1 (en) | Phosphono-spiro-bisphenols a process for their manufacture and their use | |
| DK138488A (en) | imidazole | |
| GB967718A (en) | N-substituted azaspiranes | |
| DK121383D0 (en) | PROCEDURE FOR THE PREPARATION OF 8-SUBSTITUTED PYRROLIZIDE INGREDIENTS | |
| DK52082A (en) | PROCEDURE FOR THE PREPARATION OF QUINON DERIVATIVES | |
| GB1100714A (en) | 3-deoxy-ribofuranosyl derivatives | |
| GB977071A (en) | Hydroxylamine derivatives and process for making them | |
| GB804087A (en) | Derivatives of leucauramine | |
| GB932531A (en) | Substituted amides | |
| GB1023205A (en) | -triazino(5,6-6) indoles | |
| GB961434A (en) | Dibasic acid imides | |
| GB959993A (en) | Camphor derivatives | |
| GB1088102A (en) | Halogen substituted pyrido-pyrimidines | |
| ES455043A1 (en) | 5-Alkylureido-1,3,4-thiadiazol-2-yl-sulfonyl-acetic acid derivatives | |
| SE7601714L (en) | SUBSTITUTED INDANYLPROPION ACIDS | |
| ES430132A1 (en) | 3,4-Dihydro-1,2,4-triazine compounds | |
| GB1107698A (en) | Process for the manufacture of tellurophenes | |
| GB1010997A (en) | Pyrimidine derivatives | |
| GB1113382A (en) | Novel pyrimidine derivatives and their preparation | |
| GB1036419A (en) | A process for the manufacture of isoquinoline derivatives |