GB908976A - Process for the manufacture of í~-dehydrosteroids - Google Patents

Process for the manufacture of í~-dehydrosteroids

Info

Publication number
GB908976A
GB908976A GB2732160A GB2732160A GB908976A GB 908976 A GB908976 A GB 908976A GB 2732160 A GB2732160 A GB 2732160A GB 2732160 A GB2732160 A GB 2732160A GB 908976 A GB908976 A GB 908976A
Authority
GB
United Kingdom
Prior art keywords
pregnatriene
prepared
bacteria
pregnatrienes
dione
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2732160A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Farbwerke Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG, Farbwerke Hoechst AG filed Critical Hoechst AG
Publication of GB908976A publication Critical patent/GB908976A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P33/00—Preparation of steroids

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

D 1,4,17(20)-pregnatrienes of the general formula <FORM:0908976/IV (b)/1> wherein R represents a hydrogen atom or a methyl or ethyl group and X represents \s7 C=O or <FORM:0908976/IV (b)/2> are prepared by subjecting the corresponding 4,17(20)-pregnadienes to the action of bacteria of the genus Corynebacterium or of the species Bacillus sphaericus or of enzymes formed by these bacteria, under aerobic conditions. Suitable bacteria of the genus Corynebacterium are C. simplex and C. hoagii. The treatment may be carried out in the presence of methanol and/or b -phenylnaphthylamine. In the examples the following compounds are prepared:- D 1,4,17(20)-pregnatriene-11b ,21-diol-3-one, 6a - methyl - D 1,4,17(20)-pregnatriene-11b ,21-diol-3-one and D 1,4,17(20)-pregnatriene-21-ol-3,11-dione. The pregnatrienes of the above general formula may be converted into the corresponding 21-acetates. D 4,17(20)-pregnadien-21-ol-3,11-dione is prepared by oxidising the corresponding 11b -hydroxy-21-acetoxy compound and hydrolysing the resulting 21-acetate of the desired compound. Specification 829,903 is referred to.
GB2732160A 1959-08-05 1960-08-05 Process for the manufacture of í~-dehydrosteroids Expired GB908976A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DEF29102A DE1107225B (en) 1959-08-05 1959-08-05 Process for the production of 1, 4, 17 (20) -Pregnatrienes

Publications (1)

Publication Number Publication Date
GB908976A true GB908976A (en) 1962-10-24

Family

ID=7093159

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2732160A Expired GB908976A (en) 1959-08-05 1960-08-05 Process for the manufacture of í~-dehydrosteroids

Country Status (2)

Country Link
DE (1) DE1107225B (en)
GB (1) GB908976A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0054810A2 (en) * 1980-12-23 1982-06-30 Schering Aktiengesellschaft Process for the preparation of 3-oxo-delta-1,4-steroids
EP0055832A1 (en) * 1980-12-23 1982-07-14 Schering Aktiengesellschaft Process for the preparation of 11-beta, 21-dihydroxy-2'-methyl-5'-beta-H-1,4-pregnadieno-(16,17-d)-oxazole-3,20-dione

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2880217A (en) * 1956-04-06 1959-03-31 Olin Mathieson delta1, 4 pregnadiene-11alpha, 20beta-diol-3-one

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0054810A2 (en) * 1980-12-23 1982-06-30 Schering Aktiengesellschaft Process for the preparation of 3-oxo-delta-1,4-steroids
EP0055832A1 (en) * 1980-12-23 1982-07-14 Schering Aktiengesellschaft Process for the preparation of 11-beta, 21-dihydroxy-2'-methyl-5'-beta-H-1,4-pregnadieno-(16,17-d)-oxazole-3,20-dione
EP0054810A3 (en) * 1980-12-23 1983-09-28 Schering Aktiengesellschaft Berlin Und Bergkamen Process for the preparation of 3-oxo-delta-1,4-steroids

Also Published As

Publication number Publication date
DE1107225B (en) 1961-05-25

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