GB896818A - Improvements in or relating to steroids and the manufacture thereof - Google Patents

Improvements in or relating to steroids and the manufacture thereof

Info

Publication number
GB896818A
GB896818A GB35321/61A GB3532161A GB896818A GB 896818 A GB896818 A GB 896818A GB 35321/61 A GB35321/61 A GB 35321/61A GB 3532161 A GB3532161 A GB 3532161A GB 896818 A GB896818 A GB 896818A
Authority
GB
United Kingdom
Prior art keywords
compound
formula
double bond
steroids
relating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB35321/61A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of GB896818A publication Critical patent/GB896818A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P33/00—Preparation of steroids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Steroid Compounds (AREA)

Abstract

The invention comprises a compound having the formula <FORM:0896818/IV (b)/1> wherein R is a b -hydroxymethylene or carbonyl group, X is fluorine, chlorine or bromine and the 1,2-carbon atom linkage denotes a single or double bond linkage and a process for the preparation thereof by subjecting a compound of the formula <FORM:0896818/IV (b)/2> to reduction, e.g. with zinc in acetic acid, sodium bisulphite, or sodium or potassium thiosulphate. A D 1-double bond may be introduced by microbiological fermentation. Alternatively a 9,11-halohydrin is dehydrated to form a 9,11-dehydro compound, said 9,11-dehydro compound is treated with hypohalous acid followed by epoxidation to form a 9,11-oxido compound which is reacted with HF.
GB35321/61A 1959-03-25 1960-03-17 Improvements in or relating to steroids and the manufacture thereof Expired GB896818A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US896818XA 1959-03-25 1959-03-25

Publications (1)

Publication Number Publication Date
GB896818A true GB896818A (en) 1962-05-16

Family

ID=22219020

Family Applications (1)

Application Number Title Priority Date Filing Date
GB35321/61A Expired GB896818A (en) 1959-03-25 1960-03-17 Improvements in or relating to steroids and the manufacture thereof

Country Status (1)

Country Link
GB (1) GB896818A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1201342B (en) * 1963-03-05 1965-09-23 Olin Mathieson Method of making steroids

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1201342B (en) * 1963-03-05 1965-09-23 Olin Mathieson Method of making steroids

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