GB924368A - Steroid compounds - Google Patents

Steroid compounds

Info

Publication number
GB924368A
GB924368A GB2531559A GB2531559A GB924368A GB 924368 A GB924368 A GB 924368A GB 2531559 A GB2531559 A GB 2531559A GB 2531559 A GB2531559 A GB 2531559A GB 924368 A GB924368 A GB 924368A
Authority
GB
United Kingdom
Prior art keywords
pregnadienes
hydrogen atom
pregnadiene
reactant
general formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2531559A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of GB924368A publication Critical patent/GB924368A/en
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J5/00Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J75/00Processes for the preparation of steroids in general

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

The invention comprises 16a - and 16b -methyl-1,4,6-pregnatrienes of the general formula <FORM:0924368/IV(a)/1> wherein R represents a hydrogen atom or an acyl radical, R1 represents a hydroxyl or keto group, X represents a hydrogen or halogen atom, and the preparation thereof by dehydrogenating the corresponding 4,6-pregnadienes with selenium dioxide, or the corresponding 1,4-pregnadienes with chloranil and the preparation of the above compounds wherein R represents a hydrogen atom by treating the corresponding 4,6-pregnadienes, wherein R represents a hydrogen atom or an acyl radical, with the dehydrogenating activity produced by growing Bacillus sphaericus micro-organisms. The above processes may be modified in that a 4,6-pregnadiene reactant is prepared by a process claimed in Specification 923,125, and 1,4-pregnadiene reactant is prepared by a process claimed in Specification 877,086. A 21-hydroxy-1,4,6-pregnatriene of the above general formula may be esterified to form the corresponding 21-acyloxy compound. Specifications 877,085 and 906,443 also are referred to.
GB2531559A 1958-08-06 1959-07-23 Steroid compounds Expired GB924368A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US75340858A 1958-08-06 1958-08-06
US81099659A 1959-05-05 1959-05-05

Publications (1)

Publication Number Publication Date
GB924368A true GB924368A (en) 1963-04-24

Family

ID=27115738

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2531559A Expired GB924368A (en) 1958-08-06 1959-07-23 Steroid compounds

Country Status (2)

Country Link
BE (1) BE581422A (en)
GB (1) GB924368A (en)

Also Published As

Publication number Publication date
BE581422A (en) 1960-02-08

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