ES282577A1 - Procedure for preparing unsaturated 6-methyl-16-methylene-steroids (Machine-translation by Google Translate, not legally binding)
- Google Patents
Procedure for preparing unsaturated 6-methyl-16-methylene-steroids (Machine-translation by Google Translate, not legally binding)
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Merck KGaA
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E Merck AG
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Publication of ES282577A1publicationCriticalpatent/ES282577A1/en
Preparation Of Compounds By Using Micro-Organisms
(AREA)
Abstract
Process for preparing unsaturated 6-methyl-16-methylene-steroids of the general formula ** (See formula) ** in which X = H o well F Y = free or esterified hydroxy group R = H, OH where = 0 as well as its 1-dehydro derivatives, characterized in that a 6-methyl steroid of the formula is treated with chloranil ** (See formula) ** in which X and Y have the meaning stated above, R1 means H, H or R and A - B means (see formula) or ** (See formula) ** and, whenever R1 means hydrogen, a hydroxy group is introduced in position 11, by treatment with a hydroxylating microorganism in 11, as well as, in order to prepare the corresponding 1-dehydro derivatives, a double bond is additionally introduced in position 1.2. , by treatment with 2,3-dichloro-5,6-dicyano-p-benzoquinone or with dehydrogenating microorganisms in position 1,2. (Machine-translation by Google Translate, not legally binding)
ES0282577A1961-11-181962-11-17Procedure for preparing unsaturated 6-methyl-16-methylene-steroids (Machine-translation by Google Translate, not legally binding)
ExpiredES282577A1
(en)
Novel processes for preparing steroid compounds, the comopounds when thus prepared, novel steroid compounds thereby prepared, and pharmaceutical compositions containing the novel compounds