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Syntex SA
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Syntex SA
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Priority to ES0243524ApriorityCriticalpatent/ES243524A1/en
Publication of ES243524A1publicationCriticalpatent/ES243524A1/en
Pharmaceuticals Containing Other Organic And Inorganic Compounds
(AREA)
Abstract
Process for obtaining fluoropregnenes, characterized in that in the compounds of the formula: ** (See formula) ** where R1, R2 and R3 signify hydrogen or a free or esterified hydroxy group, hydrogen or a methyl group, X hydrogen, a chloro or fluoro atom and Y two hydrogen atoms, an oxo group, or hydrogen and a free hydroxy group or esterified, and that in the 3 and 20 position present hydrogen or a free or esterified hydroxy group, or a ketalized or free oxo group, are treated with boron trifluoride, a free or esterified hydroxy group or ketalized oxo group in the 3-position transforms into a free oxo group, the 6 β -fluoro-5 α -hydroxy compounds obtained are dehydrated, the compounds Δ 4-3-oxo-6 β - are isomerized to compounds Δ 4-3-oxo-6 α fluoro and, at any reaction stage, the esterified hydroxy groups are hydrolysed or the free hydroxy groups are esterified. (Machine-translation by Google Translate, not legally binding)
ES0243524A1958-08-081958-08-08Procedure for the obtaining of fluoropregnenos (Machine-translation by Google Translate, not legally binding)
ExpiredES243524A1
(en)