GB904681A - Substituted hydrazines and process for their preparation - Google Patents

Substituted hydrazines and process for their preparation

Info

Publication number
GB904681A
GB904681A GB36721/60A GB3672160A GB904681A GB 904681 A GB904681 A GB 904681A GB 36721/60 A GB36721/60 A GB 36721/60A GB 3672160 A GB3672160 A GB 3672160A GB 904681 A GB904681 A GB 904681A
Authority
GB
United Kingdom
Prior art keywords
formula
compounds
alkyl
cnh2noh
hydroxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB36721/60A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warner Lambert Co LLC
Original Assignee
Warner Lambert Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Pharmaceutical Co filed Critical Warner Lambert Pharmaceutical Co
Publication of GB904681A publication Critical patent/GB904681A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention comprises compounds of the general formula <FORM:0904681/IV (b)/1> wherein X represents a hydrogen or a halogen atom, a hydroxy or a C1-4 alkoxy group, R1 and R2 represent C1-4 alkyl groups of the formula CnH2nY, wherein n is 2 or 3 and Y is a chlorine atom or a hydroxy, di-(C1-4 alkyl) amino, piperidino, morpholino, piperazino or pyrrolidino group and the preparation thereof by either (a) reacting a phenone of the formula <FORM:0904681/IV (b)/2> with a carbazic acid derivative of the formula <FORM:0904681/IV (b)/3> to form the hydrazone <FORM:0904681/IV (b)/4> and reducing the hydrozone, preferably catalytically, if desired carrying out the condensation and reduction in a single step; or (b) reacting a hydrazine of the formula <FORM:0904681/IV (b)/5> with a carbonate of the formula <FORM:0904681/IV (b)/6> to form the compounds of the invention wherein R2 is CnH2nOH, and (c) if desired, treating the compounds obtained from (a) or (b) in which R2 is CnH2nOH with a chlorinating agent to convert R2 to CnH2nCl., and (d) if desired, treating the compounds from (e) with a di-(C1-4 alkyl) amine, piperidine, morpholine, piperazine or pyrrolidine to replace the chlorine atom by the corresponding amino group. Anti depressant compositions comprise the compounds of the invention in admixture with a pharmaceutical carrier. The compositions may be in the form of tablets, capsules, syrups elixirs, parenteral solutions and suppositories.
GB36721/60A 1959-11-05 1960-10-26 Substituted hydrazines and process for their preparation Expired GB904681A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US85098859A 1959-11-05 1959-11-05

Publications (1)

Publication Number Publication Date
GB904681A true GB904681A (en) 1962-08-29

Family

ID=25309654

Family Applications (1)

Application Number Title Priority Date Filing Date
GB36721/60A Expired GB904681A (en) 1959-11-05 1960-10-26 Substituted hydrazines and process for their preparation

Country Status (2)

Country Link
FR (1) FR867M (en)
GB (1) GB904681A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1293148B (en) * 1962-10-01 1969-04-24 Roussel Uclaf Process for the production of new 1-benzyl-3-isopropyl-carbazinate
JPS5936655A (en) * 1982-05-04 1984-02-28 エジツト・ジヨジセルベジエセテイ・ジヤ−ル Carbazic acid derivative and manufacture, and composition

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1293148B (en) * 1962-10-01 1969-04-24 Roussel Uclaf Process for the production of new 1-benzyl-3-isopropyl-carbazinate
JPS5936655A (en) * 1982-05-04 1984-02-28 エジツト・ジヨジセルベジエセテイ・ジヤ−ル Carbazic acid derivative and manufacture, and composition

Also Published As

Publication number Publication date
FR867M (en) 1961-10-16

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