GB903808A - New steroid compounds and processes for their preparation - Google Patents

New steroid compounds and processes for their preparation

Info

Publication number
GB903808A
GB903808A GB137661A GB137661A GB903808A GB 903808 A GB903808 A GB 903808A GB 137661 A GB137661 A GB 137661A GB 137661 A GB137661 A GB 137661A GB 903808 A GB903808 A GB 903808A
Authority
GB
United Kingdom
Prior art keywords
methyl
pregnan
processes
acyloxy
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB137661A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratoires Francais de Chimiotherapie SA
Original Assignee
Laboratoires Francais de Chimiotherapie SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratoires Francais de Chimiotherapie SA filed Critical Laboratoires Francais de Chimiotherapie SA
Publication of GB903808A publication Critical patent/GB903808A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)

Abstract

The invention comprises the 11,18-lactones of 11b - hydroxy - 16a -methyl-5b -pregnan-18b -oic acid of the formula: <FORM:0903808/IV (b)/1> where R represents a hydrogen atom or an acyl radical and processes for the preparation thereof in which a 3a -acyloxy-16a -methyl-5b -pregna-11,20-dione is reduced to give 3a -acyloxy - 16a - methyl - 20-hydroxy-5b -pregnan-11-one, which is reacted with lead tetracetate to yield a 3a -acyloxy-16a -methyl-18,20-epoxy-5b -pregnan-11-one and this latter compound is oxidised and saponified to yield 3a ,20-dihydroxy-16a -methyl-18,20-epoxy - 5b - pregna-11,18-dione which is then reduced and treated with acid to form the 11,18-lactone of 3a , 11b , 20b -trihydroxy-16a -methyl - 5b - pregnan - 18b -oic acid. The latter compound may be esterified to obtain the corresponding 11,18-lactone of 3a ,20b - diacyloxy-11b -hydroxy-16a -methyl-5b -pregnan-18b -oic acid. The reductive steps may be effected with lithium aluminium hydride and the oxidation step with chromic acid.
GB137661A 1960-01-15 1961-01-12 New steroid compounds and processes for their preparation Expired GB903808A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR815786A FR1254574A (en) 1960-01-15 1960-01-15 New 18-oxygenated steroids and method of preparation

Publications (1)

Publication Number Publication Date
GB903808A true GB903808A (en) 1962-08-22

Family

ID=8723870

Family Applications (1)

Application Number Title Priority Date Filing Date
GB137661A Expired GB903808A (en) 1960-01-15 1961-01-12 New steroid compounds and processes for their preparation

Country Status (4)

Country Link
BE (1) BE599083A (en)
CH (1) CH394190A (en)
FR (1) FR1254574A (en)
GB (1) GB903808A (en)

Also Published As

Publication number Publication date
FR1254574A (en) 1961-02-24
BE599083A (en) 1961-07-13
CH394190A (en) 1965-06-30

Similar Documents

Publication Publication Date Title
GB1048232A (en) New steroid compounds and processes for their preparation
GB903808A (en) New steroid compounds and processes for their preparation
GB1003305A (en) Novel steroid compounds and their preparation
GB935610A (en) 3ªá-amino-pregnane compounds
GB967080A (en) Novel steroid compounds and process for the preparation thereof
GB957221A (en) Novel steroid compounds and processes for their preparation
GB965929A (en) Novel steroid compounds and their production
GB965928A (en) Processes for the production of steroid compounds,and the new compounds thereby obtained
GB1015016A (en) New steroid compounds and processes
GB921156A (en) Synthesis of steroids
GB966492A (en) Improvements in or relating to steroids and the manufacture thereof
GB952492A (en) New steroid compounds and processes for their preparation
GB805497A (en) Steroid intermediates for the preparation of adreno-cortical hormones
GB973899A (en) Novel steroid compounds and their preparation
GB973927A (en) Thiazolosteroids and production thereof
GB988656A (en) Improvements in or relating to steroids and the manufacture thereof
GB1101791A (en) New 1ª‡:7ª‡-dimethyl steroids and a process for their manufacture
GB991474A (en) Novel steroid compounds and their preparation
GB899371A (en) Steroid compounds
GB929273A (en) Steroids and their production
GB933277A (en) New steroid compounds and processes for their preparation
GB943956A (en) Novel steroid compounds and processes for their preparation
GB988805A (en) New steroid compounds and processes for their preparation and conversion into pharmacologically-useful compounds
GB970487A (en) Novel steroids compounds and processes for the preparation thereof
GB979898A (en) New fused polycyclic hydrocarbon derivatives and processes for the preparation thereof