GB988805A - New steroid compounds and processes for their preparation and conversion into pharmacologically-useful compounds - Google Patents
New steroid compounds and processes for their preparation and conversion into pharmacologically-useful compoundsInfo
- Publication number
- GB988805A GB988805A GB16265/64A GB1626564A GB988805A GB 988805 A GB988805 A GB 988805A GB 16265/64 A GB16265/64 A GB 16265/64A GB 1626564 A GB1626564 A GB 1626564A GB 988805 A GB988805 A GB 988805A
- Authority
- GB
- United Kingdom
- Prior art keywords
- group
- hydroxymethylene
- ketonide
- pregnan
- pregnane
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01M—PROCESSES OR MEANS, e.g. BATTERIES, FOR THE DIRECT CONVERSION OF CHEMICAL ENERGY INTO ELECTRICAL ENERGY
- H01M8/00—Fuel cells; Manufacture thereof
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01M—PROCESSES OR MEANS, e.g. BATTERIES, FOR THE DIRECT CONVERSION OF CHEMICAL ENERGY INTO ELECTRICAL ENERGY
- H01M8/00—Fuel cells; Manufacture thereof
- H01M8/06—Combination of fuel cells with means for production of reactants or for treatment of residues
- H01M8/0606—Combination of fuel cells with means for production of reactants or for treatment of residues with means for production of gaseous reactants
- H01M8/0612—Combination of fuel cells with means for production of reactants or for treatment of residues with means for production of gaseous reactants from carbon-containing material
- H01M8/0625—Combination of fuel cells with means for production of reactants or for treatment of residues with means for production of gaseous reactants from carbon-containing material in a modular combined reactor/fuel cell structure
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01M—PROCESSES OR MEANS, e.g. BATTERIES, FOR THE DIRECT CONVERSION OF CHEMICAL ENERGY INTO ELECTRICAL ENERGY
- H01M8/00—Fuel cells; Manufacture thereof
- H01M8/08—Fuel cells with aqueous electrolytes
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01M—PROCESSES OR MEANS, e.g. BATTERIES, FOR THE DIRECT CONVERSION OF CHEMICAL ENERGY INTO ELECTRICAL ENERGY
- H01M8/00—Fuel cells; Manufacture thereof
- H01M8/14—Fuel cells with fused electrolytes
- H01M8/141—Fuel cells with fused electrolytes the anode and the cathode being gas-permeable electrodes or electrode layers
- H01M8/142—Fuel cells with fused electrolytes the anode and the cathode being gas-permeable electrodes or electrode layers with matrix-supported or semi-solid matrix-reinforced electrolyte
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01M—PROCESSES OR MEANS, e.g. BATTERIES, FOR THE DIRECT CONVERSION OF CHEMICAL ENERGY INTO ELECTRICAL ENERGY
- H01M8/00—Fuel cells; Manufacture thereof
- H01M8/14—Fuel cells with fused electrolytes
- H01M2008/147—Fuel cells with molten carbonates
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01M—PROCESSES OR MEANS, e.g. BATTERIES, FOR THE DIRECT CONVERSION OF CHEMICAL ENERGY INTO ELECTRICAL ENERGY
- H01M2300/00—Electrolytes
- H01M2300/0017—Non-aqueous electrolytes
- H01M2300/0048—Molten electrolytes used at high temperature
- H01M2300/0051—Carbonates
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
- Y02E60/00—Enabling technologies; Technologies with a potential or indirect contribution to GHG emissions mitigation
- Y02E60/30—Hydrogen technology
- Y02E60/50—Fuel cells
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Manufacturing & Machinery (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Sustainable Development (AREA)
- Sustainable Energy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Electrochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Steroid Compounds (AREA)
Abstract
The invention comprises 5b -pregnanes having the general formula <FORM:0988805/C2/1> where either R1 is a hydrogen atom, in which case R2 is the group (H, b -OH) and R3 and R4 either each is a hydrogen atom or together are the group >C.R5R6, or R1 is an acyl group derived from a lower aliphatic carboxylic acid having 2-7 carbon atoms, in which case R2 is either the group (H1 b -OH) or the oxygen atom of a keto group, and R3 and R4 together are the group >C.R5R6,R5 and R6, which may be the same or different, each represents an alkyl group having 1-4 carbon atoms, and processes for the preparation thereof which comprise treating a 3a -hydroxy-20-carboalkoxy-5b - pregnan - 11 - on - 21 - oic acid alkyl ester having the general formula <FORM:0988805/C2/2> (wherein R7 and R8 are the same or different and are each an alkyl group having 1-6 carbon atoms) with a mixed metal hydride so as to simultaneously reduce the 11-keto group and to both reduce and saponify the carboalkoxy groupings attached at the 20-position, thus yielding 3a ,11b ,21 - trihydroxy - 20 - hydroxymethylene - 5b - pregnane, reacting the latter with a lower aliphatic ketone in the presence of a dehydrating agent to yield the corresponding ketonide of 3a ,11b ,21 - trihydroxy - 20 - hydroxymethylene - 5b - pregnane, reacting the latter with an acylating agent to yield the corresponding ketonide of a 3a -acyloxy-11b ,21-dihydroxy - 20 - hydroxymethylene - 5b -pregnane, oxidizing the latter with a mixture of sulphuric and chromic acid to obtain the corresponding ketonide of a 3a -acyloxy-21-hydroxy-20 - hydroxymethylene - 5b - pregnan - 11 - one and subjecting the latter to hydrolysis to obtain 3a - acyloxy - 21 - hydroxy - 20 - hydroxymethylene - 5b - pregnan - 11 - one. Specification 967,078 also is referred to.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR850596A FR1331326A (en) | 1961-01-24 | 1961-01-24 | New process for the preparation of bis-hydroxymethyl pregnane derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB988805A true GB988805A (en) | 1965-04-14 |
Family
ID=8747349
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB16265/64A Expired GB988805A (en) | 1961-01-24 | 1962-01-24 | New steroid compounds and processes for their preparation and conversion into pharmacologically-useful compounds |
Country Status (7)
| Country | Link |
|---|---|
| BE (1) | BE612981A (en) |
| BR (1) | BR6235933D0 (en) |
| CH (1) | CH409950A (en) |
| DE (1) | DE1215707B (en) |
| ES (1) | ES273977A1 (en) |
| FR (2) | FR1331326A (en) |
| GB (1) | GB988805A (en) |
-
1961
- 1961-01-24 FR FR850596A patent/FR1331326A/en not_active Expired
- 1961-04-22 FR FR859596A patent/FR1407M/en active Active
-
1962
- 1962-01-23 BE BE612981A patent/BE612981A/en unknown
- 1962-01-23 CH CH79162A patent/CH409950A/en unknown
- 1962-01-23 ES ES0273977A patent/ES273977A1/en not_active Expired
- 1962-01-24 GB GB16265/64A patent/GB988805A/en not_active Expired
- 1962-01-24 BR BR135933/62A patent/BR6235933D0/en unknown
- 1962-01-24 DE DER31956A patent/DE1215707B/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| BE612981A (en) | 1962-07-23 |
| FR1331326A (en) | 1963-07-05 |
| CH409950A (en) | 1966-03-31 |
| BR6235933D0 (en) | 1973-05-24 |
| FR1407M (en) | 1962-07-23 |
| DE1215707B (en) | 1966-05-05 |
| ES273977A1 (en) | 1962-05-01 |
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