GB970588A - New steroid compounds and processes for their preparation - Google Patents

New steroid compounds and processes for their preparation

Info

Publication number
GB970588A
GB970588A GB8251/64A GB825164A GB970588A GB 970588 A GB970588 A GB 970588A GB 8251/64 A GB8251/64 A GB 8251/64A GB 825164 A GB825164 A GB 825164A GB 970588 A GB970588 A GB 970588A
Authority
GB
United Kingdom
Prior art keywords
processes
preparation
acid
pregn
treatment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB8251/64A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Publication of GB970588A publication Critical patent/GB970588A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B22—CASTING; POWDER METALLURGY
    • B22C—FOUNDRY MOULDING
    • B22C9/00—Moulds or cores; Moulding processes
    • B22C9/02—Sand moulds or like moulds for shaped castings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Steroid Compounds (AREA)

Abstract

The invention comprises pregn-4-en-3-one derivatives having the general formula: <FORM:0970588/C1/1> in which R6 represents two hydrogen atoms or the methylene group =CH2, Y indicates an hydrogen atom or an acyl group derived either from an organic carboxylic acid having from 1-18 carbon atoms or from a mineral acid, and R7 represents the groups =H(OH) or the oxygen atom =O and their corresponding 3-ketal derivatives, and processes for the preparation thereof wherein a 3-ketal of pregn-4-ene-3,11,21-trione having the formulae: <FORM:0970588/C1/2> <FORM:0970588/C1/3> is reduced e.g. with sodium borohydride to obtain the corresponding 21-hydroxy compound which is deketalized at 3-position by treatment with an acid e.g. H2SO4, HCl. The products so obtained may be esterified by treatment with an acylating agent derived from an organic carboxylic or mineral acid e.g. HNO3. The 11-hydroxy compounds are preferably obtained by reduction of the 3,11-dione e.g. with lithium aluminium hydride to form the 3,11b -dihydroxy compound and reoxidizing e.g. with MnO2 to yield a 3-keto-11b -hydroxy compound. Specification 970,587 also is referred to.
GB8251/64A 1960-08-10 1961-08-10 New steroid compounds and processes for their preparation Expired GB970588A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR835529A FR1365261A (en) 1960-08-10 1960-08-10 Novel 3-oxo delta steroid compounds and method of preparation

Publications (1)

Publication Number Publication Date
GB970588A true GB970588A (en) 1964-09-23

Family

ID=8737231

Family Applications (3)

Application Number Title Priority Date Filing Date
GB8251/64A Expired GB970588A (en) 1960-08-10 1961-08-10 New steroid compounds and processes for their preparation
GB7833/64A Expired GB970587A (en) 1960-08-10 1961-08-10 New steroid compounds and processes for their preparation
GB28983/61A Expired GB970586A (en) 1960-08-10 1961-08-10 New steroid compounds and processes for their preparation

Family Applications After (2)

Application Number Title Priority Date Filing Date
GB7833/64A Expired GB970587A (en) 1960-08-10 1961-08-10 New steroid compounds and processes for their preparation
GB28983/61A Expired GB970586A (en) 1960-08-10 1961-08-10 New steroid compounds and processes for their preparation

Country Status (4)

Country Link
CH (4) CH399454A (en)
ES (4) ES269700A1 (en)
FR (4) FR1365261A (en)
GB (3) GB970588A (en)

Also Published As

Publication number Publication date
CH399456A (en) 1965-09-30
ES269699A1 (en) 1961-11-16
FR754M (en) 1961-08-21
FR753M (en) 1961-08-21
GB970587A (en) 1964-09-23
ES269700A1 (en) 1961-11-16
ES269697A1 (en) 1961-11-16
GB970586A (en) 1964-09-23
CH399455A (en) 1965-09-30
FR1365261A (en) 1964-07-03
CH399454A (en) 1965-09-30
ES269698A1 (en) 1961-11-16
CH401963A (en) 1965-11-15
FR752M (en) 1961-08-21

Similar Documents

Publication Publication Date Title
GB1048231A (en) New steroid compounds, compositions incorporating them and processes for their preparation
GB902292A (en) Improvements in or relating to steroids and the manufacture thereof
GB970588A (en) New steroid compounds and processes for their preparation
GB1075545A (en) Improvements in or relating to steroids and the manufacture thereof
GB1060793A (en) Improvements in or relating to steroids and the manufacture thereof
GB935116A (en) New cyclopentanophenanthrene derivatives and processes for the production thereof
GB1001703A (en) 2-formyl-í¸-17ª‰-hydroxy-androstene compounds and process for their production
GB1084467A (en) Improvements in or relating to steroids and the manufacture thereof
GB1003305A (en) Novel steroid compounds and their preparation
GB959869A (en) Oxasteroids of the pregnane series
GB896027A (en) New cyclopentanophenanthrene derivatives
GB959792A (en) Improvements in or relating to steroids
GB1018780A (en) Steroid (2,3í¬c) furazan compounds and the process for the production thereof
GB988656A (en) Improvements in or relating to steroids and the manufacture thereof
GB1048246A (en) í¸-androstenes and í¸-androstadienes and process for their production
GB1055926A (en) A novel class of steroid compounds
GB947000A (en) Process for the production of steroid compounds, and the new compounds thus produced
GB991475A (en) Novel steroid compounds and processes for their production
GB966492A (en) Improvements in or relating to steroids and the manufacture thereof
GB852680A (en) 2-alpha-methyl-4-pregnenes and method of preparing the same
GB1051185A (en)
GB799493A (en) Dehydrocortical hormones
GB965929A (en) Novel steroid compounds and their production
GB1082954A (en) Steroid derivatives
GB951060A (en) Cyclopentanophenanthrene compounds and process for their preparation