GB888974A - Steroids - Google Patents
SteroidsInfo
- Publication number
- GB888974A GB888974A GB1898459A GB1898459A GB888974A GB 888974 A GB888974 A GB 888974A GB 1898459 A GB1898459 A GB 1898459A GB 1898459 A GB1898459 A GB 1898459A GB 888974 A GB888974 A GB 888974A
- Authority
- GB
- United Kingdom
- Prior art keywords
- trione
- diol
- methyl
- pregnane
- acylate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
2,4 - Dibromo - 16a - methyl - pregnane - 17a ,21 - diol - 3,11,20 - trione 21 - acylate is prepared by reacting 16a -methyl-pregnane-17a ,21-diol-3,11,20-trione with a brominating agent, e.g. bromine. 16a - Methyl - 1,4 - pregnadiene - 17a ,21 - diol - 3,11,20 - trione 21 - acylate is prepared by dehydrobrominating the above 2,4-dibromo compound, e.g. with a tertiary amine such as dimethylaniline or collidine, and optionally hydrolysing the 21-ester group to form the corresponding free 21-hydroxy compound. The 21-ester group may be derived from acetic, propionic, butyric or benzoic acid. Detailed examples are given. Specification 877,086 is referred to.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US74396858A | 1958-06-23 | 1958-06-23 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB888974A true GB888974A (en) | 1962-02-07 |
Family
ID=24990906
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB1898459A Expired GB888974A (en) | 1958-06-23 | 1959-06-03 | Steroids |
Country Status (4)
Country | Link |
---|---|
BE (1) | BE579372A (en) |
CH (1) | CH377815A (en) |
DE (1) | DE1418320A1 (en) |
GB (1) | GB888974A (en) |
-
1959
- 1959-05-29 DE DE19591418320 patent/DE1418320A1/en active Pending
- 1959-06-03 GB GB1898459A patent/GB888974A/en not_active Expired
- 1959-06-05 BE BE579372A patent/BE579372A/en unknown
- 1959-06-22 CH CH7474959A patent/CH377815A/en unknown
Also Published As
Publication number | Publication date |
---|---|
BE579372A (en) | 1959-12-07 |
CH377815A (en) | 1964-05-31 |
DE1418320A1 (en) | 1968-10-10 |
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