GB888974A - Steroids - Google Patents

Steroids

Info

Publication number
GB888974A
GB888974A GB1898459A GB1898459A GB888974A GB 888974 A GB888974 A GB 888974A GB 1898459 A GB1898459 A GB 1898459A GB 1898459 A GB1898459 A GB 1898459A GB 888974 A GB888974 A GB 888974A
Authority
GB
United Kingdom
Prior art keywords
trione
diol
methyl
pregnane
acylate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1898459A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of GB888974A publication Critical patent/GB888974A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

2,4 - Dibromo - 16a - methyl - pregnane - 17a ,21 - diol - 3,11,20 - trione 21 - acylate is prepared by reacting 16a -methyl-pregnane-17a ,21-diol-3,11,20-trione with a brominating agent, e.g. bromine. 16a - Methyl - 1,4 - pregnadiene - 17a ,21 - diol - 3,11,20 - trione 21 - acylate is prepared by dehydrobrominating the above 2,4-dibromo compound, e.g. with a tertiary amine such as dimethylaniline or collidine, and optionally hydrolysing the 21-ester group to form the corresponding free 21-hydroxy compound. The 21-ester group may be derived from acetic, propionic, butyric or benzoic acid. Detailed examples are given. Specification 877,086 is referred to.
GB1898459A 1958-06-23 1959-06-03 Steroids Expired GB888974A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US74396858A 1958-06-23 1958-06-23

Publications (1)

Publication Number Publication Date
GB888974A true GB888974A (en) 1962-02-07

Family

ID=24990906

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1898459A Expired GB888974A (en) 1958-06-23 1959-06-03 Steroids

Country Status (4)

Country Link
BE (1) BE579372A (en)
CH (1) CH377815A (en)
DE (1) DE1418320A1 (en)
GB (1) GB888974A (en)

Also Published As

Publication number Publication date
BE579372A (en) 1959-12-07
CH377815A (en) 1964-05-31
DE1418320A1 (en) 1968-10-10

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