GB912378A - Steroid compounds - Google Patents

Steroid compounds

Info

Publication number
GB912378A
GB912378A GB1898559A GB1898559A GB912378A GB 912378 A GB912378 A GB 912378A GB 1898559 A GB1898559 A GB 1898559A GB 1898559 A GB1898559 A GB 1898559A GB 912378 A GB912378 A GB 912378A
Authority
GB
United Kingdom
Prior art keywords
acylates
pregnatriene
pregnadiene
bromo
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1898559A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of GB912378A publication Critical patent/GB912378A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general

Abstract

The invention comprises 16(a and b )-methyl-1,4,9(11)-pregnatriene-17a ,21-diol - 3,20 -diones and the 21-acylates thereof, and 16(a and b )-9a (bromo and chloro)-11b ,17a ,21-trihydroxy-1,4-pregnadiene-3,20-diones and the 21-acylates thereof, and a process for the preparation of the above 1,4,9(11)-pregnatriene 21-acylates by reacting 16(a and b )-methyl-1,4-pregnadiene-11b ,17a ,21-triol-3,20-dione 21-acylates with a dehydrating agent, and a process for the preparation of 16(a and b )-methyl-1,4-pregnadiene-9a (bromo or chloro)-11b ,17a ,21-triol-3,20-dione 21-acylates by treating the 1,4,9(11)-pregnatriene 21-acylates with hypobromous or hypochlorous acid respectively (the acid may be formed in situ using N-bromo- or N-chlorosuccinimide and perchloric acid in aqueous solution). The above processes may be modified by hydrolysing the formed 21-acylates to the corresponding 21-hydroxy compounds. Specifications 877,085, 877,086, 906,443 and 912,379 are referred to.
GB1898559A 1958-06-19 1959-06-03 Steroid compounds Expired GB912378A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US74299258A 1958-06-19 1958-06-19
US74299358A 1958-06-19 1958-06-19

Publications (1)

Publication Number Publication Date
GB912378A true GB912378A (en) 1962-12-05

Family

ID=27114087

Family Applications (2)

Application Number Title Priority Date Filing Date
GB1258562A Expired GB912379A (en) 1958-06-19 1959-06-03 Steroid compounds
GB1898559A Expired GB912378A (en) 1958-06-19 1959-06-03 Steroid compounds

Family Applications Before (1)

Application Number Title Priority Date Filing Date
GB1258562A Expired GB912379A (en) 1958-06-19 1959-06-03 Steroid compounds

Country Status (1)

Country Link
GB (2) GB912379A (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8207151B2 (en) 2008-05-28 2012-06-26 Validus Biopharma Inc. Non-hormonal steroid modulators of NF-κB for treatment of disease
US9198921B2 (en) 2010-04-05 2015-12-01 Reveragen Biopharma, Inc. Non-hormonal steroid modulators of NF-κB for treatment of disease
US10799514B2 (en) 2015-06-29 2020-10-13 Reveragen Biopharma, Inc. Non-hormonal steroid modulators of NF-kappa beta for treatment of disease
US11382922B2 (en) 2019-03-07 2022-07-12 Reveragen Biopharma, Inc. Aqueous oral pharmaceutical suspension compositions

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10857161B2 (en) 2008-05-28 2020-12-08 Reveragen Biopharma, Inc. Non-hormonal steroid modulators of NF-kB for treatment of disease
US8334279B2 (en) 2008-05-28 2012-12-18 Validus Genetics Non-hormonal steroid modulators of NF-κB for treatment of disease
US8673887B2 (en) 2008-05-28 2014-03-18 Reveragen Biopharma, Inc Non-hormonal steroid modulators of NF-kB for treatment of disease
US8207151B2 (en) 2008-05-28 2012-06-26 Validus Biopharma Inc. Non-hormonal steroid modulators of NF-κB for treatment of disease
US9434758B2 (en) 2008-05-28 2016-09-06 Reveragen Biopharma, Inc. Non-hormonal steroid modulators of NF-κB for treatment of disease
US9649320B2 (en) 2008-05-28 2017-05-16 Reveragen Biopharma, Inc. Non-hormonal steroid modulators of NF-κB for treatment of disease
US11833159B2 (en) 2008-05-28 2023-12-05 Reveragen Biopharma, Inc. Non-hormonal steroid modulators of NF-kB for treatment of disease
US10206933B2 (en) 2008-05-28 2019-02-19 Reveragen Biopharma, Inc. Non-hormonal steroid modulators of NF-kB for treatment of disease
US9198921B2 (en) 2010-04-05 2015-12-01 Reveragen Biopharma, Inc. Non-hormonal steroid modulators of NF-κB for treatment of disease
US10000525B2 (en) 2010-04-05 2018-06-19 Reveragen Biopharma, Inc. Non-hormonal steroid modulators of NF-κB for treatment of disease
US10799514B2 (en) 2015-06-29 2020-10-13 Reveragen Biopharma, Inc. Non-hormonal steroid modulators of NF-kappa beta for treatment of disease
US11690853B2 (en) 2015-06-29 2023-07-04 Reveragen Biopharma, Inc. Non-hormonal steroid modulators of NF-κβ for treatment of disease
US11382922B2 (en) 2019-03-07 2022-07-12 Reveragen Biopharma, Inc. Aqueous oral pharmaceutical suspension compositions
US11471471B2 (en) 2019-03-07 2022-10-18 Reveragen Biopharma, Inc. Aqueous oral pharmaceutical suspension compositions

Also Published As

Publication number Publication date
GB912379A (en) 1962-12-05

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