GB950573A - Improvements in the preparation of steroid compounds - Google Patents

Improvements in the preparation of steroid compounds

Info

Publication number
GB950573A
GB950573A GB2775962A GB2775962A GB950573A GB 950573 A GB950573 A GB 950573A GB 2775962 A GB2775962 A GB 2775962A GB 2775962 A GB2775962 A GB 2775962A GB 950573 A GB950573 A GB 950573A
Authority
GB
United Kingdom
Prior art keywords
hydroxy
preparation
androstene
keto
weight
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2775962A
Inventor
Rudolph Gerhard Berg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Charles Pfizer and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc, Charles Pfizer and Co Inc filed Critical Pfizer Inc
Priority to GB2775962A priority Critical patent/GB950573A/en
Publication of GB950573A publication Critical patent/GB950573A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)

Abstract

3-keto -D 4- androstene and 3-keto -D 4- pregnene compounds are obtained by reacting a 3b -hydroxy-5a , 6b -dichloroandrostane or a 3b -hydroxy-5a , 6b -dichloropregnane with at least 1% by weight of lithium chloride, based on the weight of steroid substrate used, in a solvent of the group consisting of dimethylformamide, diethylformamide, or dimethylacetamide at a temperature of at least 50 DEG C. The 3b -hydroxy -5a , 6b -dichloro androstane or pregnane starting compounds are obtained by treating with chlorine a 3b -hydroxy -D 5- androstene or pregnene to obtain the corresponding 5a , 6b -dichloro compound and hydrolysing the acylate group to form the 3b -hydroxy compound.
GB2775962A 1962-07-19 1962-07-19 Improvements in the preparation of steroid compounds Expired GB950573A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB2775962A GB950573A (en) 1962-07-19 1962-07-19 Improvements in the preparation of steroid compounds

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB2775962A GB950573A (en) 1962-07-19 1962-07-19 Improvements in the preparation of steroid compounds

Publications (1)

Publication Number Publication Date
GB950573A true GB950573A (en) 1964-02-26

Family

ID=10264806

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2775962A Expired GB950573A (en) 1962-07-19 1962-07-19 Improvements in the preparation of steroid compounds

Country Status (1)

Country Link
GB (1) GB950573A (en)

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