GB883259A - Improvements in or relating to vitamin compositions comprising cobalamine and ascorbic acid - Google Patents

Improvements in or relating to vitamin compositions comprising cobalamine and ascorbic acid

Info

Publication number
GB883259A
GB883259A GB20430/59A GB2043059A GB883259A GB 883259 A GB883259 A GB 883259A GB 20430/59 A GB20430/59 A GB 20430/59A GB 2043059 A GB2043059 A GB 2043059A GB 883259 A GB883259 A GB 883259A
Authority
GB
United Kingdom
Prior art keywords
vitamin
acid
compositions
ascorbic acid
nitrites
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB20430/59A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of GB883259A publication Critical patent/GB883259A/en
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H23/00Compounds containing boron, silicon, or a metal, e.g. chelates, vitamin B12
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00Preparation of compounds containing saccharide radicals
    • C12P19/26Preparation of nitrogen-containing carbohydrates
    • C12P19/28N-glycosides
    • C12P19/42Cobalamins, i.e. vitamin B12, LLD factor

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Solid and liquid vitamin compositions comprise cyanocobalamin (Vitamin B12) and ascorbic acid and, as stabilizer, an organic or inorganic nitrite in a concentration equivalent to from about 0.0005% to about 0.1% by weight of NO2 of the composition. Specified nitrites are those of the alkali and alkaline earth metals (sodium nitrite is preferred), alkyl nitrites and acid nitrites e.g. nitrous acid. The compositions may be in solid form e.g. a tablet or in liquid form e.g. an aqueous solution or an emulsion. It is stated when the solvent in liquid preparations contains about 60% or more glycerin or about 50% or more propylene glycol, the stability of the cyanocobalumin in the presence of ascorbic acid and nitrite is enhanced. Other water or oil soluble vitamins may also be incorporated in the compositions these specified being Vitamin A (palmitate), Vitamin D3, F riboflavin, thiamine (hydrochloride), pantothenyl alcohol, nicotinamide, pyridoxine (hydrochloride), folic acid, calcium pentothanate. Ferrous gluconate may also be present.
GB20430/59A 1958-06-26 1959-06-15 Improvements in or relating to vitamin compositions comprising cobalamine and ascorbic acid Expired GB883259A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US883259XA 1958-06-26 1958-06-26

Publications (1)

Publication Number Publication Date
GB883259A true GB883259A (en) 1961-11-29

Family

ID=22210713

Family Applications (1)

Application Number Title Priority Date Filing Date
GB20430/59A Expired GB883259A (en) 1958-06-26 1959-06-15 Improvements in or relating to vitamin compositions comprising cobalamine and ascorbic acid

Country Status (1)

Country Link
GB (1) GB883259A (en)

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