GB1080626A - A process for stabilizing a vitamin b analogue - Google Patents
A process for stabilizing a vitamin b analogueInfo
- Publication number
- GB1080626A GB1080626A GB109864A GB109864A GB1080626A GB 1080626 A GB1080626 A GB 1080626A GB 109864 A GB109864 A GB 109864A GB 109864 A GB109864 A GB 109864A GB 1080626 A GB1080626 A GB 1080626A
- Authority
- GB
- United Kingdom
- Prior art keywords
- maleic acid
- maleate
- thiamine
- vitamin
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H23/00—Compounds containing boron, silicon, or a metal, e.g. chelates, vitamin B12
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
Aqueous solutions of Vitamin B12 compounds, especially solutions also containing Vitamin B1 compounds, are stabilized by adding maleic acid or a water-soluble sodium, potassium, calcium, magnesium, ammonium or triethanolamine maleate. Up to 2% by weight of the solution, e.g. 0.2 to 1% of the maleic acid or maleate may be used. In examples, solutions containing hydroxocobalamine and thiamine hydrochloride, thiamine tetrahydrofurfuryl disulphide hydrochloride and thiamine propyl disulphide, are stabilized with monosodium maleate and maleic acid; the solutions also contain nicotinic acid amide, benzyl alcohol, polyoxyethylene sorbitan and pyridoxine.ALSO:Aqueous solutions containing vitamin B12 compounds and vitamin B1 compounds, are stabilized by adding maleic acid or a water soluble sodium, potassium, calcium, magnesium, ammonium or triethanolamine maleate. Up to 2% by weight of the solution, e.g. 0.2 to 1%, of the maleic acid or maleate may be used. In Examples monosodium maleate and maleic acid are added to solutions containing hydroxocobalamine, thiamine hydrochloride, thiamine tetrahydrofurfuryl disulphide hydrochloride, thiamine propyl disulphide, nicotinic acid amide, benzyl alcohol, pyridoxine and polyoxyethylene sorbitan.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP5521763 | 1963-10-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1080626A true GB1080626A (en) | 1967-08-23 |
Family
ID=12992436
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB109864A Expired GB1080626A (en) | 1963-10-14 | 1964-10-08 | A process for stabilizing a vitamin b analogue |
| GB4109964A Expired GB1076858A (en) | 1963-10-14 | 1964-10-08 | A method for stabilizing vitamin b and its analogue |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB4109964A Expired GB1076858A (en) | 1963-10-14 | 1964-10-08 | A method for stabilizing vitamin b and its analogue |
Country Status (2)
| Country | Link |
|---|---|
| DE (1) | DE1249453B (en) |
| GB (2) | GB1080626A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4740373A (en) * | 1986-05-27 | 1988-04-26 | Usv Pharmaceutical Corporation | Stabilization of multivitamin/trace elements formulations |
| US4804535A (en) * | 1986-05-27 | 1989-02-14 | Rorer Pharmaceutical Corporation | Stabilization of multivitamin/trace elements formulations |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT376879B (en) * | 1982-10-27 | 1985-01-10 | Gerot Pharmazeutika | METHOD FOR PRODUCING AN INJECTION SOLUTION |
-
0
- DE DENDAT1249453D patent/DE1249453B/de active Pending
-
1964
- 1964-10-08 GB GB109864A patent/GB1080626A/en not_active Expired
- 1964-10-08 GB GB4109964A patent/GB1076858A/en not_active Expired
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4740373A (en) * | 1986-05-27 | 1988-04-26 | Usv Pharmaceutical Corporation | Stabilization of multivitamin/trace elements formulations |
| US4804535A (en) * | 1986-05-27 | 1989-02-14 | Rorer Pharmaceutical Corporation | Stabilization of multivitamin/trace elements formulations |
Also Published As
| Publication number | Publication date |
|---|---|
| DE1249453B (en) | |
| GB1076858A (en) | 1967-07-26 |
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