GB652284A - Preparations of stabilized solutions of thiamine - Google Patents

Preparations of stabilized solutions of thiamine

Info

Publication number
GB652284A
GB652284A GB3825/48A GB382548A GB652284A GB 652284 A GB652284 A GB 652284A GB 3825/48 A GB3825/48 A GB 3825/48A GB 382548 A GB382548 A GB 382548A GB 652284 A GB652284 A GB 652284A
Authority
GB
United Kingdom
Prior art keywords
water
thiamine mononitrate
stabilized solutions
thiamine
preparations
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3825/48A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of GB652284A publication Critical patent/GB652284A/en
Expired legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A61K31/51Thiamines, e.g. vitamin B1

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

Stabilized solutions are prepared by dissolving thiamine mononitrate or a vitamin B complex containing thiamine mononitrate, riboflavin, pyridoxine hydrochloride and niacinamide in water or aqueous chlorobutanol, and adjusting the pH of the solution to about 3.5 to 4.5 by the addition of a water-soluble non-toxic inorganic acid, e.g. hydrochloric, sulphuric or nitric acid.ALSO:Stabilized solutions for parenteral administration are prepared by dissolving thiamine mononitrate or a vitamin B complex containing thiamine mononitrate, riboflaving, pyridoxine dydrochloride and niacinamide in water or aqueous chlorobutanol, and adjusting the pH of the solution to about 3.5 to 4.5 by the addition of a water-soluble non-toxic inorganic acid, e.g. hydrochloric, sulphuric or nitric acid.
GB3825/48A 1947-03-08 1948-02-10 Preparations of stabilized solutions of thiamine Expired GB652284A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US652284XA 1947-03-08 1947-03-08

Publications (1)

Publication Number Publication Date
GB652284A true GB652284A (en) 1951-04-18

Family

ID=22061219

Family Applications (1)

Application Number Title Priority Date Filing Date
GB3825/48A Expired GB652284A (en) 1947-03-08 1948-02-10 Preparations of stabilized solutions of thiamine

Country Status (1)

Country Link
GB (1) GB652284A (en)

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