GB684459A - A stable aqueous solution of dihydrostreptomycin and method of preparing same - Google Patents
A stable aqueous solution of dihydrostreptomycin and method of preparing sameInfo
- Publication number
- GB684459A GB684459A GB9481/51A GB948151A GB684459A GB 684459 A GB684459 A GB 684459A GB 9481/51 A GB9481/51 A GB 9481/51A GB 948151 A GB948151 A GB 948151A GB 684459 A GB684459 A GB 684459A
- Authority
- GB
- United Kingdom
- Prior art keywords
- dihydrostreptomycin
- salt
- citrate
- sodium
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Saccharide Compounds (AREA)
Abstract
Dihydrostreptomycin is stabilized in aqueous solution by the addition of a buffering agent, e.g. citrate, phosphate or acetate and one or more substances selected from a salt of sulphurous acid, a salt of hydrosulphurous acid and an aldehyde addition product thereof as a stabilizing agent. Preferably the pH is adjusted to pH 5.0 to 8.0. Specified stabilizers are sodium bisulphite, sodium formaldehyde sulphoxylate, potassium metabisulphite and sodium hydrosulphite. Instead of a dihydrostreptomycin salt such as the sulphate or hydrochloride and a buffer, the citrate salt of dihydrostreptomycin may be used at a pH 5.0-8.0 without added buffering agent. The citrate may be produced by neutralizing the dihydrostreptomycin base with citric acid to pH 5.0 to 5.5.ALSO:Stable aqueous solutions of dihydrostreptomycin salts such as the sulphate and hydrochloride are prepared by adding thereto a buffering agent such as a citrate, phosphate or acetate buffer, and one or more substances selected from a salt of sulphurous acid, a salt of hydrosulphurous acid and an aldehyde addition product thereof as a stabilizing agent. The pH of the solution is preferably adjusted to pH 5.0 to 8.0. Specified stabilizers are sodium bisulphite, sodium formaldehyde sulphoxylate, potassium metabisulphite and sodium hydrosulphite. Instead of a dihydrostreptomycin salt such as the sulphate or hydrochloride and a buffer, dihydrostreptomycin citrate may be used without added buffering agent. The citrate may be produced by neutralizing the dihydrostreptomycin base with citric acid to a pH 5.0 to 5.5.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US684459XA | 1950-05-10 | 1950-05-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB684459A true GB684459A (en) | 1952-12-17 |
Family
ID=22082637
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB9481/51A Expired GB684459A (en) | 1950-05-10 | 1951-04-24 | A stable aqueous solution of dihydrostreptomycin and method of preparing same |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB684459A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE964632C (en) * | 1953-08-07 | 1957-05-23 | Merck & Co Inc | Process for the production of colourfast, durable streptomycin solutions of high effectiveness |
-
1951
- 1951-04-24 GB GB9481/51A patent/GB684459A/en not_active Expired
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE964632C (en) * | 1953-08-07 | 1957-05-23 | Merck & Co Inc | Process for the production of colourfast, durable streptomycin solutions of high effectiveness |
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