GB636221A - Improvements in or relating to the stabilisation of streptomycin solutions - Google Patents
Improvements in or relating to the stabilisation of streptomycin solutionsInfo
- Publication number
- GB636221A GB636221A GB14134/47A GB1413447A GB636221A GB 636221 A GB636221 A GB 636221A GB 14134/47 A GB14134/47 A GB 14134/47A GB 1413447 A GB1413447 A GB 1413447A GB 636221 A GB636221 A GB 636221A
- Authority
- GB
- United Kingdom
- Prior art keywords
- sodium
- streptomycin
- stabilization
- inert atmosphere
- toxic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Streptomycin is stabilized in solution by the presence of a protective agent in the form of a non-toxic, compatible salt having a mild reducing action and the adjustment of the pH to a predetermined value, the solution so formed being placed in a sealed container and then sterilized by heat, and all operations beginning with the dissolving of the streptomycin and ending with the sealing of the container being performed under an inert atmosphere. The protective agents are soluble bisulphites, thiosulphates, hypophosphites, formaldehyde sulphoxylates and bitartrates of non-toxic alkaline cations such as the alkali and alkaline earth metals, ammonia, organic amines and heterocyclic groups containing nitrogen of which sodium, potassium, calcium, ethylamine, benzylamine, pyridine and piperidine are specified. A pH of 3 to 6, preferably 3.68 to 5.5 and for optimum results 4.85, is employed with nitrogen as the preferred inert atmosphere. Examples are given of the stabilization of aqueous solutions of streptomycin sulphate in which (a) sodium metabisulphite and (b) sodium formaldehyde sulphoxylate are the protective agents. Sodium lactate or sodium citrate may also be present. The Specification as open to inspection under Sect. 91 relates to the stabilization of antibiotics in general. This subject-matter does not appear in the Specification as accepted.ALSO:Streptomycin is stabilized in solution by the presence of a protective agent in the form of a non-toxic, compatible salt having a mild reducing action, and the adjustment of the pH to a predetermined value, the solution so formed being placed in a sealed container and then sterilized by heat, and all operations beginning with the dissolving of the streptomycin and ending with the sealing of the container being performed under an inert atmosphere. The protective agents are soluble bisulphates, thiosulphates, hypophosphites, formaldehyde sulphoxylates and bitartrates of non-toxic alkaline cations such as the alkali and alkaline earth metals, ammonia, organic amines and heterocyclic groups containing nitrogen of which sodium, potassium, calcium, ethylamine, benzylamine, pyridine and piperidine are specified. A pH of 3 to 6, preferably 3.68 to 5.5 and for optimum results 4.85 is employed with nitrogen as the preferred inert atmosphere. Examples are given of the stabilization of aqueous solutions of streptomycin sulphate in which (a) sodium metabisulphite and (b) sodium formaldehyde sulphoxylate are the protective agents. Sodium lactate or sodium citrate may also be present. The Specification as open to inspection under Sect. 91 relates to the stabilization of antibiotics in general. This subject-matter does not appear in the Specification as accepted.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US636221XA | 1946-06-13 | 1946-06-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB636221A true GB636221A (en) | 1950-04-26 |
Family
ID=22050416
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB14134/47A Expired GB636221A (en) | 1946-06-13 | 1947-05-27 | Improvements in or relating to the stabilisation of streptomycin solutions |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB636221A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE964632C (en) * | 1953-08-07 | 1957-05-23 | Merck & Co Inc | Process for the production of colourfast, durable streptomycin solutions of high effectiveness |
-
1947
- 1947-05-27 GB GB14134/47A patent/GB636221A/en not_active Expired
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE964632C (en) * | 1953-08-07 | 1957-05-23 | Merck & Co Inc | Process for the production of colourfast, durable streptomycin solutions of high effectiveness |
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