GB8827391D0 - Process for preparation of 2-(2-(4-((4-chlorophenyl)phenylmethyl)-1-pipera-zinyl)ethoxy)-acetic acid & its dihydrochloride - Google Patents

Process for preparation of 2-(2-(4-((4-chlorophenyl)phenylmethyl)-1-pipera-zinyl)ethoxy)-acetic acid & its dihydrochloride

Info

Publication number
GB8827391D0
GB8827391D0 GB888827391A GB8827391A GB8827391D0 GB 8827391 D0 GB8827391 D0 GB 8827391D0 GB 888827391 A GB888827391 A GB 888827391A GB 8827391 A GB8827391 A GB 8827391A GB 8827391 D0 GB8827391 D0 GB 8827391D0
Authority
GB
United Kingdom
Prior art keywords
zinyl
pipera
phenylmethyl
dihydrochloride
chlorophenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
GB888827391A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
UCB SA
Original Assignee
UCB SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by UCB SA filed Critical UCB SA
Priority to GB888827391A priority Critical patent/GB8827391D0/en
Publication of GB8827391D0 publication Critical patent/GB8827391D0/en
Priority to CA000614709A priority patent/CA1317300C/en
Priority to GR890100770A priority patent/GR1000553B/el
Priority to PT92364A priority patent/PT92364B/pt
Priority to GB8926243A priority patent/GB2225321B/en
Priority to HU896131A priority patent/HU205094B/hu
Priority to DK198905867A priority patent/DK174543B1/da
Priority to FI895564A priority patent/FI91862C/fi
Priority to ES8903975A priority patent/ES2021907A6/es
Priority to NO894651A priority patent/NO172342C/no
Priority to AT0266589A priority patent/AT398971B/de
Priority to PL1989282410A priority patent/PL161379B1/pl
Priority to PH39570A priority patent/PH25982A/en
Priority to KR1019890017040A priority patent/KR970009728B1/ko
Priority to SG894/92A priority patent/SG89492G/en
Priority to HK958/92A priority patent/HK95892A/xx
Priority to CY1671A priority patent/CY1671A/xx
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
GB888827391A 1988-11-23 1988-11-23 Process for preparation of 2-(2-(4-((4-chlorophenyl)phenylmethyl)-1-pipera-zinyl)ethoxy)-acetic acid & its dihydrochloride Pending GB8827391D0 (en)

Priority Applications (17)

Application Number Priority Date Filing Date Title
GB888827391A GB8827391D0 (en) 1988-11-23 1988-11-23 Process for preparation of 2-(2-(4-((4-chlorophenyl)phenylmethyl)-1-pipera-zinyl)ethoxy)-acetic acid & its dihydrochloride
CA000614709A CA1317300C (en) 1988-11-23 1989-09-29 Process for the preparation of 2-¬2-¬4-¬(4-chlorophenyl) phenylmethyl|-1-piperazinyl|ethoxy|-acetic acid and its dihydrochloride
GR890100770A GR1000553B (el) 1988-11-23 1989-11-20 Μεθοδος παρασκευης του 2-(2-(4-((4-χλωριοφαινυλ)φαινυλμεθυλ)-1-πιπεραζινυλ)αιθοξυ) οξικου οξεος και του διυδροχλωρικου αλατιου του.
PT92364A PT92364B (pt) 1988-11-23 1989-11-21 Processo para a preparacao de acido 2-{2-{(4-cloridrato)- fenilmetil}-1- -piperazinil}etoxi}-acetico e do seu cloridrato
GB8926243A GB2225321B (en) 1988-11-23 1989-11-21 A process for the preparation of 2-(2-(4-((4-chlorophenyl)phenylmethyl)-1-piperazinyl)ethoxy)-acetic acid and its dihydrochloride
PL1989282410A PL161379B1 (pl) 1988-11-23 1989-11-22 S p o só b wytwarzania kwasu 2-[2-[4-[/4-chlorofenylo/fenylom etylo]-1-piperazynylo] etoksy]octow ego i jego dichlorowodorku PL PL
ES8903975A ES2021907A6 (es) 1988-11-23 1989-11-22 Procedimiento de preparacion del acido 2-(2-(-4( (4-clorofenil) fenilmetil)-1-piperazinil)etoxi)acetico y de su dihidrocloruro".
DK198905867A DK174543B1 (da) 1988-11-23 1989-11-22 Fremgangsmåde til fremstilling af 2-[2-[4-[[(4-chlorphenyl)phenylmethyl)]-1-piperazinyl]ethoxy]eddikesyre og dens dihydrochlorid og udgangsforbindelse til anvendelse ved fremgangsmåden
FI895564A FI91862C (fi) 1988-11-23 1989-11-22 2-/2-/4-/(4-kloorifenyyli)fenyylimetyyli/-1-piperatsinyyli/etoksi/-etikkahapon ja sen dihydrokloridin valmistusmenetelmä
HU896131A HU205094B (en) 1988-11-23 1989-11-22 New process for producing 2-/2-/4-/(4-chlorophenyl)-phenylmethyl/-1-piperazinyl/-ethoxy/-acetic acid and its salts
NO894651A NO172342C (no) 1988-11-23 1989-11-22 Fremgangsmaate for fremstilling av 2-(2-(4-((4-klorfenyl)-fenylmethyl)-1-piperazinyl)-ethoxy)-eddiksyre og dens dihydroklorid, og mellomprodukt for anvendelse ved fremgangsmaaten
AT0266589A AT398971B (de) 1988-11-23 1989-11-22 Verfahren zur herstellung der 2-(2-(4-((4-chlor- phenyl)-phenylmethyl)-1-piperazinyl)ethoxy)- essigsäure und ihres dichlorhydrats
PH39570A PH25982A (en) 1988-11-23 1989-11-23 A process for the preparation of 2-(2-((4-chlorophenyl) phenyl-methyl)-1-piperazinyl) ethoxy) acetic acid and its dihydrochloride
KR1019890017040A KR970009728B1 (ko) 1988-11-23 1989-11-23 2-[2-[4-[(4-클로로페닐)페닐메틸]-1-피페라지닐]에톡시]-아세트산 및 그의 중염산염의 제조방법
SG894/92A SG89492G (en) 1988-11-23 1992-09-05 A process for the preparation of 2-(2-(4-((4-chlorophenyl)phenylmethyl)-1-piperazinyl)ethoxy)-acetic acid and its dihydrochloride
HK958/92A HK95892A (en) 1988-11-23 1992-12-03 A process for the preparation of 2-(2-(4-((4-chlorophenyl)phenylmethyl)-1-piperazinyl)ethoxy)-acetic acid and its dihydrochloride
CY1671A CY1671A (en) 1988-11-23 1993-05-14 A process for the preparation of 2-(2-(4-((4-chlorophenyl)phenylmethyl)-1-piperazinyl)ethoxy)-acetic acid and its dihydrochloride

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB888827391A GB8827391D0 (en) 1988-11-23 1988-11-23 Process for preparation of 2-(2-(4-((4-chlorophenyl)phenylmethyl)-1-pipera-zinyl)ethoxy)-acetic acid & its dihydrochloride

Publications (1)

Publication Number Publication Date
GB8827391D0 true GB8827391D0 (en) 1988-12-29

Family

ID=10647347

Family Applications (2)

Application Number Title Priority Date Filing Date
GB888827391A Pending GB8827391D0 (en) 1988-11-23 1988-11-23 Process for preparation of 2-(2-(4-((4-chlorophenyl)phenylmethyl)-1-pipera-zinyl)ethoxy)-acetic acid & its dihydrochloride
GB8926243A Expired - Lifetime GB2225321B (en) 1988-11-23 1989-11-21 A process for the preparation of 2-(2-(4-((4-chlorophenyl)phenylmethyl)-1-piperazinyl)ethoxy)-acetic acid and its dihydrochloride

Family Applications After (1)

Application Number Title Priority Date Filing Date
GB8926243A Expired - Lifetime GB2225321B (en) 1988-11-23 1989-11-21 A process for the preparation of 2-(2-(4-((4-chlorophenyl)phenylmethyl)-1-piperazinyl)ethoxy)-acetic acid and its dihydrochloride

Country Status (16)

Country Link
KR (1) KR970009728B1 (da)
AT (1) AT398971B (da)
CA (1) CA1317300C (da)
CY (1) CY1671A (da)
DK (1) DK174543B1 (da)
ES (1) ES2021907A6 (da)
FI (1) FI91862C (da)
GB (2) GB8827391D0 (da)
GR (1) GR1000553B (da)
HK (1) HK95892A (da)
HU (1) HU205094B (da)
NO (1) NO172342C (da)
PH (1) PH25982A (da)
PL (1) PL161379B1 (da)
PT (1) PT92364B (da)
SG (1) SG89492G (da)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0950412A3 (en) * 1992-09-24 2001-05-16 Sepracor, Inc. Compositions for treating allergic disorders using (-) cetirizine
AU703690B2 (en) * 1992-09-24 1999-04-01 Sepracor, Inc. Methods for treating allergic disorders using optically pure (+)cetirizine
AU5136193A (en) * 1992-09-24 1994-04-12 Sepracor, Inc. Methods and compositions for treating allergic disorders using optically pure (+) cetirizine
GB9305282D0 (en) 1993-03-15 1993-05-05 Ucb Sa Enantiomers of 1-(4-chlorophenyl)phenylmethyl)-4-(4-methylphenyl)sulphonyl)piperazine
US6469009B1 (en) 1996-04-08 2002-10-22 Ucb, S.A. Pharmaceutical compositions for the treatment of rhinitis
BE1010094A3 (fr) * 1996-04-10 1997-12-02 Ucb Sa Nouveaux [2-(1-piperazinyl)ethoxy] methyle substitues.
BE1010095A3 (fr) * 1996-04-10 1997-12-02 Ucb Sa Procede de preparation de l'acide 2-[2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl] ethoxy]-acetique et de ses sels.
AU7455798A (en) 1997-06-04 1998-12-21 Nippon Shoji Kaisha, Ltd. Process for producing piperazinesulfonamide derivatives and salts thereof
EP0919550A1 (en) 1997-11-26 1999-06-02 Ucb, S.A. Pseudopolymorphic forms of 2-2-4-bis(4-fluorophenyl)methyl-1-piperazinyl-ethoxy acetic acid dihydrochloride
IL124195A (en) * 1998-04-23 2000-08-31 Chemagis Ltd Process for the preparation of esters of 2-¬4-¬4-chlorophenyl¾phenylmethyl¾-1-piperazinyl¬ethoxy¾acetic acid
GR990100135A (el) * 1999-04-22 2000-12-29 Genepharm �.�. Μεθοδος παρασκευης του 2-(2-[4-[4-χλωροφαινυλο)(φαινυλο)μεθυλο]πιπεραζινο]αιθοξυ) οξικου οξεος και του διυδροχλωρικου αλατος αυτου
JP2002249487A (ja) * 2001-02-22 2002-09-06 Sumitomo Chem Co Ltd ４−（ｔｅｒｔ−ブトキシカルボニル）ピペラジン誘導体、その光学活性な酸付加塩、それらの製造法、およびそれらを用いる光学活性な１−［（置換フェニル）フェニルメチル］ピペラジンの製造法。
US7199241B1 (en) 2001-05-29 2007-04-03 Ucb, S.A. Process for preparing (S) and (R)-2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide
US6977301B1 (en) 2001-05-29 2005-12-20 Ucb, S.A. Process for preparing (S) and (R)—2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide
US7381821B2 (en) 2003-01-23 2008-06-03 Ucb, S.A. Piperazine derivatives and their use as synthesis intermediates
KR100503443B1 (ko) 2004-02-02 2005-07-22 한림제약(주) 광학적으로 활성인 세티리진 또는 그의 염의 제조방법
CA2599498C (en) * 2005-03-03 2011-06-21 Ucb Farchim Sa Pyroglutamate salts and their use in the optical resolution of intermediates for the synthesis of dextrocetirizine and levocetirizine
HU227325B1 (en) * 2005-12-08 2011-03-28 Egis Gyogyszergyar Nyrt Process for the production of an intermediate of (dextro- and levo)- cetirizine
US8049011B2 (en) 2007-03-12 2011-11-01 Krka, Tovarna Zdravil, D.D., Novo Mesto Process for the preparation of levocetirizine and intermediates thereof
SI22489A (sl) * 2007-03-12 2008-10-31 Krka, Tovarna Zdravil, D.D., Novo Mesto Nov postopek za pripravo levocetirizina in njegovih intermediatov
EP2167479B1 (en) 2007-06-15 2013-09-11 Symed Labs Limited Process for preparation of substantially optically pure levorotatory and dextrorotatory enantiomers of cetirizine using novel intermediates
WO2009062036A2 (en) * 2007-11-09 2009-05-14 Dr. Reddy's Laboratories Ltd. Processes for preparing levocetirizine and pharmaceutically acceptable salts thereof
ATE499352T1 (de) 2007-11-21 2011-03-15 Synthon Bv Verfahren zur herstellung von n- (diphenylmethyl)piperazinen
US7989623B2 (en) 2007-11-21 2011-08-02 Synthon Bv Process for making n-(diphenylmethyl)piperazines
WO2009147389A2 (en) 2008-06-02 2009-12-10 Cipla Limited Processes for the synthesis of levocetirizine and intermediates for use therein
WO2009150147A1 (en) * 2008-06-11 2009-12-17 Krka, Tovarna Zdravil, D.D., Novo Mesto New process for the preparation of levocetirizine and intermediates thereof
KR100998067B1 (ko) 2008-09-08 2010-12-03 주식회사 삼오제약 비스(1-[(4-클로로페닐)페닐메틸]피페라진)-2,3-디벤조일 타르타르산 신규 중간체 염 및 이를 이용한 광학 활성적으로 순수한 1-[(4-클로로페닐)페닐메틸]피페라진을 분리하는 분리방법
US20110172425A1 (en) 2008-09-17 2011-07-14 Calyx Chemicals And Pharmaceuticals Pvt. Ltd. Novel water based process for the preparation of substituted diphenylmethyl piperazines
WO2010107404A1 (en) 2009-03-16 2010-09-23 Mahmut Bilgic Stable pharmaceutical combinations
TR201007652A2 (tr) 2010-09-20 2012-04-24 Bi̇lgi̇ç Mahmut Sinerjik etki.
TR201009398A2 (tr) 2010-11-11 2012-05-21 Bi̇lgi̇ç Mahmut Fiziksel özellikleri geliştirilmiş tablet formülasyonları
WO2012101475A1 (en) 2011-01-27 2012-08-02 Jubilant Life Sciences Limited An improved process for the preparation of antihistaminic drugs via a novel carbamate intermediate
CN103044355A (zh) * 2011-10-13 2013-04-17 湖南九典制药有限公司 合成左西替利嗪的关键中间体及其制备方法
KR101418404B1 (ko) 2012-01-06 2014-07-10 한미약품 주식회사 레보세티리진 또는 이의 약학적으로 허용가능한 염 및 몬테루카스트 또는 이의 약학적으로 허용가능한 염을 함유하는 안정한 경구투여용 약학 제제
KR102226833B1 (ko) 2013-06-28 2021-03-12 한미약품 주식회사 레보세티리진 및 몬테루카스트를 포함하는 안정성이 개선된 복합 과립 제형
CN104045607B (zh) * 2014-05-21 2016-04-13 丽珠医药集团股份有限公司 一种盐酸西替利嗪的纯化方法
CN105924409B (zh) * 2016-05-12 2019-01-08 浙江永宁药业股份有限公司 一种(r)-1-((2-氯苯基)-(苯基)-甲基)-哌嗪的拆分方法
CN111205247B (zh) * 2020-04-22 2020-08-14 湖南九典宏阳制药有限公司 左旋西替利嗪的制备方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO155805C (no) * 1981-02-06 1987-06-10 Ucb Sa Analogifremgangsmaate for fremstilling av terapeutisk virksomme 2-(4-(difenylmethyl)-1-piperazinyl)-eddiksyrer og deres amider og ikke-toksiske salter.

Also Published As

Publication number Publication date
NO894651L (no) 1990-05-25
DK586789D0 (da) 1989-11-22
KR970009728B1 (ko) 1997-06-17
PT92364A (pt) 1990-05-31
NO172342B (no) 1993-03-29
CA1317300C (en) 1993-05-04
SG89492G (en) 1992-12-04
FI895564A0 (fi) 1989-11-22
GB2225321B (en) 1992-04-08
GB2225321A (en) 1990-05-30
ATA266589A (de) 1994-07-15
ES2021907A6 (es) 1991-11-16
PT92364B (pt) 1995-07-18
NO172342C (no) 1993-07-07
FI91862B (fi) 1994-05-13
GR1000553B (el) 1992-08-26
HU896131D0 (en) 1990-02-28
FI91862C (fi) 1994-08-25
PL161379B1 (pl) 1993-06-30
KR900007825A (ko) 1990-06-02
NO894651D0 (no) 1989-11-22
GR890100770A (en) 1990-12-31
DK174543B1 (da) 2003-05-19
HU205094B (en) 1992-03-30
GB8926243D0 (en) 1990-01-10
HUT53627A (en) 1990-11-28
CY1671A (en) 1993-05-14
PH25982A (en) 1992-01-13
DK586789A (da) 1990-05-24
AT398971B (de) 1995-02-27
HK95892A (en) 1992-12-11

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