GB877056A - Preparation of sulphonamides - Google Patents
Preparation of sulphonamidesInfo
- Publication number
- GB877056A GB877056A GB18560/58A GB1856058A GB877056A GB 877056 A GB877056 A GB 877056A GB 18560/58 A GB18560/58 A GB 18560/58A GB 1856058 A GB1856058 A GB 1856058A GB 877056 A GB877056 A GB 877056A
- Authority
- GB
- United Kingdom
- Prior art keywords
- phosphorus
- chloride
- chlorinating agent
- reaction
- sulphur
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/37—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
Abstract
Disulphamoyl aniline compounds of the general formula <FORM:0877056/IV (b)/1> in which R1 is halogen (e.g. Br, Cl, F) C1-C5 alkyl or alkoxy or nitro or amino and R2 is hydrogen or a C1-C5 alkyl group are made by chlorosulphonating an aniline compound of the formula <FORM:0877056/IV (b)/2> wherein R3 may be hydrogen or a C1-C6 alkanoyl group, by reacting with chlorosulphonic acid, heating the reaction mixture in the presence of a chlorinating agent containing phosphorus or sulphur, e.g. thionyl chloride, sulphonyl chloride, phosphorus trichloride or phosphorus pentachloride and treating the resulting disulphonyl chloride with ammonia. Preferably, the initial reaction with chlorosulphonic acid is carried out at 125-130 DEG C., the reaction mixture is then cooled, at least two moles of the phosphorus- or sulphur - containing chlorinating agent are added and the reaction is continued by heating below the boiling point of the chlorinating agent, quenching with water and treating the separated disulphonyl chloride with at least 4 equivalents of ammonia in a solvent such as water, methanol, benzene, isopropanol or t-butanol. Specifications 826,922 and 826,924 are referred to.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US877056XA | 1957-06-17 | 1957-06-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB877056A true GB877056A (en) | 1961-09-13 |
Family
ID=22206779
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB18560/58A Expired GB877056A (en) | 1957-06-17 | 1958-06-10 | Preparation of sulphonamides |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB877056A (en) |
-
1958
- 1958-06-10 GB GB18560/58A patent/GB877056A/en not_active Expired
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