GB8721383D0 - Preparation of methylene derivatives - Google Patents

Preparation of methylene derivatives

Info

Publication number
GB8721383D0
GB8721383D0 GB878721383A GB8721383A GB8721383D0 GB 8721383 D0 GB8721383 D0 GB 8721383D0 GB 878721383 A GB878721383 A GB 878721383A GB 8721383 A GB8721383 A GB 8721383A GB 8721383 D0 GB8721383 D0 GB 8721383D0
Authority
GB
United Kingdom
Prior art keywords
preparation
hydrogen
methylene derivatives
chem
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
GB878721383A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Farmitalia Carlo Erba SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to GB878721383A priority Critical patent/GB8721383D0/en
Application filed by Farmitalia Carlo Erba SRL filed Critical Farmitalia Carlo Erba SRL
Publication of GB8721383D0 publication Critical patent/GB8721383D0/en
Priority to EP88308103A priority patent/EP0307134B1/en
Priority to DE8888308103T priority patent/DE3872995T2/de
Priority to ES88308103T priority patent/ES2051858T3/es
Priority to AT88308103T priority patent/ATE78488T1/de
Priority to IL87657A priority patent/IL87657A/xx
Priority to FI884087A priority patent/FI884087A7/fi
Priority to AU21980/88A priority patent/AU602608B2/en
Priority to JP63225508A priority patent/JP2791046B2/ja
Priority to SU884356486A priority patent/SU1681731A3/ru
Priority to CA000576897A priority patent/CA1316914C/en
Priority to UA4356486A priority patent/UA6044A1/uk
Priority to KR1019880011641A priority patent/KR970005315B1/ko
Priority to HU884665A priority patent/HU199156B/hu
Priority to US07/242,854 priority patent/US4876045A/en
Priority to GR920401628T priority patent/GR3005296T3/el
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0018—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa
    • C07J1/0022—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
GB878721383A 1987-09-11 1987-09-11 Preparation of methylene derivatives Pending GB8721383D0 (en)

Priority Applications (16)

Application Number Priority Date Filing Date Title
GB878721383A GB8721383D0 (en) 1987-09-11 1987-09-11 Preparation of methylene derivatives
EP88308103A EP0307134B1 (en) 1987-09-11 1988-09-01 Process for the preparation of methylene derivatives of androsta-1,4-diene 3-17 dione
DE8888308103T DE3872995T2 (de) 1987-09-11 1988-09-01 Verfahren zur herstellung von androsta-1,4-dien-3,17-dion-methylen-derivaten.
ES88308103T ES2051858T3 (es) 1987-09-11 1988-09-01 Un procedimiento para la preparacion de derivados de metileno.
AT88308103T ATE78488T1 (de) 1987-09-11 1988-09-01 Verfahren zur herstellung von androsta-1,4-dien3,17-dion-methylen-derivaten.
IL87657A IL87657A (en) 1987-09-11 1988-09-02 Preparation of methylene derivatives of androsta-1,4-diene-3,17-dione and pharmaceutical compositions containing them
FI884087A FI884087A7 (fi) 1987-09-11 1988-09-06 Menetelmä androsta-1,4-dieeni-3,17-dionin metyleenijohdannaisten val mistamiseksi
AU21980/88A AU602608B2 (en) 1987-09-11 1988-09-07 Process for the preparation of methylene derivatives of androsta-1, 4-diene-3,17-dione
JP63225508A JP2791046B2 (ja) 1987-09-11 1988-09-08 アンドロスタ−１，４−ジエン−３，１７−ジオンのメチレン誘導体の製造方法
SU884356486A SU1681731A3 (ru) 1987-09-11 1988-09-09 Способ получени метиленовых производных андроста-1,4-диен-3,17-диона
CA000576897A CA1316914C (en) 1987-09-11 1988-09-09 Process for the preparation of methylene derivatives of androsta-1,4-diene-3,17-dione
UA4356486A UA6044A1 (uk) 1987-09-11 1988-09-09 Спосіб одержання метіленових похідних андроста-1,4 -діен-3,17-діона
KR1019880011641A KR970005315B1 (ko) 1987-09-11 1988-09-09 안드로스타-1,4-디엔-3,17-디온의 메틸렌 유도체의 제조방법
HU884665A HU199156B (en) 1987-09-11 1988-09-09 New process for producing androsta-1,4-diene-3,17-dione-methylene derivatives
US07/242,854 US4876045A (en) 1987-09-11 1988-09-12 Process for the preparation of methylene derivatives of androsta-1,4-diene-3,17-dione
GR920401628T GR3005296T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1987-09-11 1992-07-29

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB878721383A GB8721383D0 (en) 1987-09-11 1987-09-11 Preparation of methylene derivatives

Publications (1)

Publication Number Publication Date
GB8721383D0 true GB8721383D0 (en) 1987-10-21

Family

ID=10623618

Family Applications (1)

Application Number Title Priority Date Filing Date
GB878721383A Pending GB8721383D0 (en) 1987-09-11 1987-09-11 Preparation of methylene derivatives

Country Status (16)

Country Link
US (1) US4876045A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
EP (1) EP0307134B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (1) JP2791046B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
KR (1) KR970005315B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AT (1) ATE78488T1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AU (1) AU602608B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (1) CA1316914C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (1) DE3872995T2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ES (1) ES2051858T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FI (1) FI884087A7 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
GB (1) GB8721383D0 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
GR (1) GR3005296T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
HU (1) HU199156B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IL (1) IL87657A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
SU (1) SU1681731A3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
UA (1) UA6044A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9201224D0 (en) * 1992-01-21 1992-03-11 Erba Carlo Spa Difluoromethylenandrostenone derivatives and process for their preparation
WO2001004342A1 (en) * 1999-07-07 2001-01-18 Pharmacia & Upjohn Company Process to prepare exemestane
CN1304413C (zh) * 2002-10-24 2007-03-14 上海华拓医药科技发展有限公司 一种抗癌药物依西美坦制备方法
US8183401B2 (en) * 2004-01-16 2012-05-22 Cedarburg Pharmaceuticals, Inc. Exemestane and its intermediates and methods of making the same
US10174070B2 (en) 2005-09-30 2019-01-08 Endece Llc 6-substituted estradiol derivatives and methods of use
US20070225354A1 (en) * 2006-03-21 2007-09-27 Eric Marchewitz Use of dihydrolipoamide for enhancing physical performance
US7569719B1 (en) * 2006-10-25 2009-08-04 Loctite (R&D) Limited Method of preparing electron deficient olefins
US20080275259A1 (en) 2007-05-04 2008-11-06 Scinopharm Taiwan, Ltd Process for preparing aromatase inhibitors
EP2170328A2 (en) * 2007-06-25 2010-04-07 ScinoPharm Taiwan, Ltd. Crystalline polymorph of exemestane
AU2008269148B2 (en) * 2007-06-25 2013-02-21 Scinopharm Taiwan, Ltd. Crystalline polymorph of 7-ethyl-10-hydroxycamptothecin
EP2217559B1 (en) 2007-10-24 2017-06-28 Henkel IP & Holding GmbH Electron deficient olefins
JP5518726B2 (ja) * 2007-10-24 2014-06-11 ヘンケル アイルランド リミテッド 活性メチレン試薬、およびそれから製造される硬化性組成物
US8053589B1 (en) * 2007-10-24 2011-11-08 Henkel Ireland Limited Imines and methods of preparing electron deficient olefins using such novel imines
US7973119B1 (en) 2007-10-24 2011-07-05 Loctite (R&D) Limited Adhesive systems using imines and salts thereof and precursurs to electron deficient olefins
US8686105B2 (en) 2007-10-24 2014-04-01 Henkel IP & Holding GmbH Adhesive systems using imines and salts thereof, precursors to electron deficient olefins and coreactants therefor
US10196471B1 (en) 2008-10-24 2019-02-05 Henkel IP & Holding GmbH Curable composition having an electron deficient olefin
US8399698B1 (en) 2008-10-24 2013-03-19 Henkel Ireland Limited Substituted activated methylene reagents and methods of using such reagents to form electron deficient olefins
US8377454B2 (en) 2009-05-01 2013-02-19 Parviz Gharagozloo Treating male infertility secondary to sperm oxidative stress
DK2616477T3 (en) 2010-09-14 2017-02-20 Endece Llc 6-substituted demethyl estradiol derivatives as agonists of the type ER-BETA
CN105085599A (zh) * 2014-05-16 2015-11-25 绍兴文理学院 一种依西美坦中间体17,17-乙二氧基-6-亚甲基雄甾-1,4-二烯-3-酮及其制备方法和应用
CN105294807A (zh) * 2014-06-26 2016-02-03 浙江医药股份有限公司新昌制药厂 一种依西美坦中间体肟化合物及其制备方法和应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3004508C2 (de) * 1980-02-05 1981-12-10 Schering Ag Berlin Und Bergkamen, 1000 Berlin Verfahren zur Herstellung von 6-Methylensteroiden
GB8517360D0 (en) * 1985-07-09 1985-08-14 Erba Farmitalia Substituted androsta-1,4-diene-3,17-diones

Also Published As

Publication number Publication date
EP0307134B1 (en) 1992-07-22
AU2198088A (en) 1989-03-16
SU1681731A3 (ru) 1991-09-30
DE3872995D1 (de) 1992-08-27
GR3005296T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1993-05-24
DE3872995T2 (de) 1992-12-10
CA1316914C (en) 1993-04-27
ATE78488T1 (de) 1992-08-15
EP0307134A1 (en) 1989-03-15
IL87657A (en) 1993-02-21
US4876045A (en) 1989-10-24
JP2791046B2 (ja) 1998-08-27
HU199156B (en) 1990-01-29
AU602608B2 (en) 1990-10-18
IL87657A0 (en) 1989-02-28
FI884087L (fi) 1989-03-12
UA6044A1 (uk) 1994-12-29
KR970005315B1 (ko) 1997-04-15
KR890005141A (ko) 1989-05-13
ES2051858T3 (es) 1994-07-01
FI884087A7 (fi) 1989-03-12
HUT48273A (en) 1989-05-29
JPH01104095A (ja) 1989-04-21
FI884087A0 (fi) 1988-09-06

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